Phospholipid nanoparticle fluid to replace blood volume and protect organs in severe bleeding
Official title: Development of a Phospholipid Nanoparticle-based Volume Expander for Blood Volume Replacement and Organ Protection in Hemorrhagic Shock
Funded at Vivacelle Bio, INC. · NIH-11403577 · Data updated 2026-11-12
A new, bubble-free fluid made of tiny lipid particles is being developed to quickly restore blood volume and protect organs during severe bleeding when real blood isn’t available.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vivacelle Bio, INC. NIH-funded |
| Lab location | 1 site (Fort Wayne, UNITED STATES) |
| Project start | September 15, 2026 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $313,906 |
| NIH project number | 1R43HL186835-01 |
| Project ID | NIH-11403577 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates would be patients experiencing acute hemorrhagic shock where blood products are unavailable or delayed, such as in prehospital or battlefield-like settings.
✕Less likely to help
Patients with non-hemorrhagic conditions or those not at risk of dramatic blood loss are unlikely to benefit.
What this research studies
This grant funds research to create a safe, ready-to-use fluid that can replace blood volume during hemorrhagic shock, especially in emergencies or low-resource settings. Researchers will design phospholipid nanoparticles to circulate and support circulation, aiming to reduce organ damage and improve survival. The work may involve preclinical testing of safety and effectiveness in models that mimic human blood loss, with a focus on compatibility and potential reduced risk of complications.
Why it matters
Potential benefit: If successful, the approach could provide a readily available alternative to blood transfusions, improving survival and organ protection after severe bleeding.
How similar studies have gone: Previous efforts to replace blood have faced safety concerns, making this an exploratory, novel approach with cautious optimism.
Where this research is happening
-
Vivacelle Bio, INC.
Fort Wayne, United States Active
Researchers
- Principal investigator: Simpkins, Cuthbert Ormond — Vivacelle Bio, INC.
- Study coordinator: Simpkins, Cuthbert Ormond
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.