Understanding how trauma and alcohol affect tiny blood vessels
Official title: Microvascular Leakage in Hemorrhagic Shock and Trauma
Funded at University of South Florida · NIH-11357562 · Data updated 2026-11-12
This grant explores why small blood vessels leak after injury and how alcohol may make it worse, with goals to find new ways to protect patients and improve recovery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $375,000 |
| NIH project number | 5R35GM145379-05 |
| Project ID | NIH-11357562 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals who have experienced traumatic injury and may have alcohol intoxication as a co-factor.
✕Less likely to help
Healthy individuals or patients without trauma or vascular issues are unlikely to benefit from this research.
What this research studies
If you suffer a traumatic injury, your body’s tiny blood vessels can leak, which can lead to serious problems. The researchers will use advanced analyses like RNA sequencing, protein profiling, and metabolite studies to map the signals that cause leakage and its resolution. They will also study how alcohol intoxication interacts with trauma to worsen outcomes, aiming to identify new targets for therapies beyond current options. The project is conducted at the University of South Florida and involves sophisticated molecular techniques to understand mechanisms at the cellular and tissue levels.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that reduce blood vessel leakage after injury, potentially lowering complications like sepsis and organ failure.
How similar studies have gone: Previous research has shown that vascular leakage is a key problem after trauma, and newer molecular approaches have yielded promising insights, though direct therapies remain under development.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Breslin, Jerome W — University of South Florida
- Study coordinator: Breslin, Jerome W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.