Evaluating fluid responsiveness in shock patients using tissue Doppler

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study assesses the diagnostic performance of mitral annulus velocity variation measured by tissue Doppler to evaluate fluid responsiveness in patients experiencing shock. It involves using trans thoracic ultrasound to monitor changes in the mitral annulus velocity before and after administering a fluid challenge. The goal is to determine if the variation in velocity can reliably indicate whether a patient will respond positively to fluid resuscitation. The study aims to establish a diagnostic performance threshold defined by an area under the ROC curve greater than 0.75.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient has been informed of the study and does not refuse to participate.
* Patient is at least ≥ 18 years of age.
* The patient must be beneficiary of a health insurance plan.
* Patient has shock with a mean blood pressure less than 65 mmHg (\<)
* The patient does not have acute intracranial pathology
* The referring physician has decided on a vascular filling with 500mL of crystalloids (NaCl 0.9% or Ringer lactate)

Exclusion Criteria:

* The patient has already received 2 vascular fillings since the beginning of his management
* The patient is in shock and has a contraindication to vascular filling : shock of a cardiogenic or obstructive nature
* The patient has an intracranial pathology requiring maintain a MAP ≥ 80 mmHg
* The patient is intubated or on Non-Invasive Ventilation before the vascular filling
* The patient is under court protection
* The patient is pregnant, parturient or nursing

Where it's running

• CHU de Nîmes
  Nîmes, France Recruiting

Study contacts

• Study coordinator: Laura GRAU MERCIER, MD
• Email: laura.merciergr@gmail.com
• Phone: +33675169725

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.