Using low-dose vasopressors through peripheral catheters in ICU patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the safety and efficacy of administering low-dose vasopressors through peripheral venous catheters (PVCs) in critically ill patients in the intensive care unit (ICU). Traditionally, vasopressors are delivered via central venous catheters (CVCs), which can lead to complications such as infections and thrombosis. The study aims to determine if PVCs can be a viable alternative, potentially expediting treatment and reducing the risks associated with CVC placement. By conducting a randomized control trial, the researchers hope to provide high-quality data to support the use of peripheral vasopressors in managing shock.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18 or older who do not have a central line or PICC line already placed
* Presence of shock requiring vasopressors at the following minimum doses: norepinephrine 5 mcg/min, phenylephrine 50 mcg/min, epinephrine 5 mc/min, dobutamine 5 mcg/kg/min

Exclusion Criteria:

* Urgent need for dialysis requiring placement of hemodialysis catheter
* More than two vasopressors are required to maintain a MAP \>65 on admission to the ICU
* Pregnancy or suspected pregnancy

Where it's running

• Kingston Health Sciences Center
  Kingston, Ontario, Canada Recruiting

Study contacts

• Principal investigator: Gord Dr., PhD, MD — Queen's University, Kingston Health Sciences Center
• Study coordinator: Dr. Boyd, PhD, MD
• Email: gordon.boyd@kingstonhsc.ca
• Phone: 613-549-6666

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Gastric emptying and feeding tolerance in ICU patients by vasopressor dose

  This study tests whether vasopressor dose affects how well stomach contents empty during tube feeding in critically ill patients.

  Recruiting Başakşehir Çam & Sakura City Hospital · Istanbul · NCT07802379

• Argos system to track cardiac output changes in critically ill patients

  This study tests whether the Argos monitor can reliably track how cardiac output changes after fluid administration or norepinephrine adjustments in critically ill adults already monitored with transpulmonary thermodilution.

  Recruiting Bicetre Hospital · Le Kremlin-Bicêtre · NCT07724262

• Pulse palpation vs arterial blood pressure in circulatory shock

  This study tests how well feeling for a pulse at typical sites matches the actual arterial blood pressure in adults with circulatory shock or risk of failure.

  Recruiting Region Stockholm · Stockholm, Stockholm County · NCT07609095

• Femoral vein-to-artery diameter ratio to predict fluid responsiveness

  This project will test whether a bedside ultrasound measurement of the femoral vein-to-artery diameter ratio can tell if mechanically ventilated ICU patients with acute circulatory failure or shock will increase their cardiac output after a 500 mL fluid bolus.

  Recruiting Istanbul University - Cerrahpasa · Istanbul, Istanbul · NCT07546656

• Right ventricular–arterial coupling during fluid loading in ICU patients

  This study tests how the right ventricle handles fluid changes in critically ill adults to see how it affects blood flow and congestion.

  Recruiting CHU de Reims · Reims · NCT07537621

• Looking at tiny particles in cord blood of babies born before 28 weeks

  The team will test whether extracellular vesicles in umbilical cord blood can help predict serious complications in babies born before 28 weeks of pregnancy.

  Recruiting University Hospital, Montpellier · Montpellier · NCT07273643

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.