Condition

Peripheral Arterial Disease clinical trials and research

• 72Clinical trials
• 34NIH research projects
• 1New in 30 days
• 41Countries

Newest Peripheral Arterial Disease clinical trials

All recruiting trials (72)

• Preventing lower limb artery disease in adults with diabetes using a risk-prediction model and HAPA-based nursing

  A risk-prediction model is tested in adults with type 2 diabetes to see if a nursing plan based on the HAPA model can reduce peripheral artery disease in the legs.

  Recruiting Second Affiliated Hospital of Nanchang University · Nanchang, Jang XI · NCT07881588

• Predictors of Major Adverse Limb Events After Iliac Artery Stenting

  This study tests what factors predict serious limb-related problems after iliac artery stenting in adults with peripheral artery disease.

  Recruiting I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio · Milan, Mi · NCT07672249

• New prodrug CG-0255 Besylate vs Plavix in healthy adults

  This study tests whether CG-0255 Besylate works similarly to Plavix® in healthy adults to understand how the two drugs behave in the body.

  Recruiting Phase 1 Shanghai CureGene Pharmaceutical Co., Ltd. · Miami, Florida · NCT07619885

• Radial and Ulnar Access in Vascular Interventions Registry

  This registry tests how often radial or ulnar artery access is used and what happens afterward in routine vascular procedures.

  Recruiting Mersin Medicalpark Hastanesi · Mersin, Mezitli · NCT07614386

• Remote versus in-person 30-second sit-to-stand testing for people with peripheral artery disease

  This project will test whether doing the 30-second sit-to-stand test by video works as well as doing it in person for adults aged 18–65 with Fontaine stage I–II peripheral artery disease who have a smartphone.

  Recruiting Izmir Democracy University · Izmir, Balçova · NCT07497360

• Imaging plaque activity across the body in people with symptomatic peripheral arterial disease

  This project will use whole-body PET-CT and CT angiography with several tracers to see if imaging can detect inflammation, microcalcification, and clot activity in people with symptomatic peripheral arterial disease.

  Recruiting University of Edinburgh · Edinburgh, Midlothian · NCT07472049

• Road-mapping versus ultrasound guidance for retrograde arterial puncture during angioplasty

  This trial will test whether using road mapping or ultrasound to guide retrograde arterial puncture works better and is safer for adults with critical limb-threatening ischemia who need retrograde access during angioplasty.

  Recruiting Sohag University · Sohag · NCT07427108

• Long Passeo-18 Lux balloon for leg artery blockages

  A single-arm trial tests a long paclitaxel-releasing balloon to treat new or recurring leg artery blockages in adults.

  Recruiting at 4 sites KANDO Research · Aalst and 3 other locations · NCT07385573

• IVUS-guided revascularization of leg arteries

  This trial will test whether using ultrasound inside the blood vessels during minimally invasive treatment of leg arteries improves outcomes for adults with symptomatic peripheral artery disease.

  Recruiting at 4 sites Baylor Research Institute · Dallas, Texas and 5 other locations · NCT07353905

• SRSD107 for people with chronic coronary or peripheral arterial disease

  This trial will test different doses of SRSD107 to see if they are safe and produce the expected drug effects in adults with chronic coronary or peripheral arterial disease who are taking aspirin.

  Recruiting Phase 2 Sirius Therapeutics Co., Ltd. · Beijing · NCT07318155

• Orforglipron for peripheral artery disease with intermittent claudication

  This trial will test whether taking orforglipron once daily helps people with Fontaine II peripheral artery disease (intermittent claudication) and is safe.

  Recruiting at 142 sites Phase 3 Eli Lilly and Company · Birmingham, Alabama and 168 other locations · NCT07223593

• Blood flow restriction exercise program for people with peripheral arterial disease

  This will test whether supervised blood flow restriction (BFR) resistance exercise helps adults with peripheral arterial disease walk farther and feel better.

  Recruiting University of Tennessee Graduate School of Medicine · Knoxville, Tennessee · NCT07223437

• See if virtual reality can ease pain during a less invasive leg procedure

  This trial tests whether wearing a virtual reality headset during lower limb revascularization under local anesthesia can lessen pain for adults with peripheral artery disease.

  Recruiting Poitiers University Hospital · Poitiers · NCT07181434

• Long-term follow-up of Advanta VXT and Flixene vascular grafts

  This registry will track how well Advanta VXT and Flixene vascular grafts work and how safe they are in adults who received them for peripheral arterial disease.

  Recruiting at 2 sites Atrium Medical Corporation · Boston, Massachusetts and 1 other locations · NCT07161583

• Evero everolimus-coated balloon versus paclitaxel-coated balloon for femoropopliteal PAD

  This study will test whether an Everolimus-coated balloon works as safely and effectively as paclitaxel-coated balloons to open blockages in leg arteries for people with PAD and walking pain.

  Recruiting at 15 sites Cook Group Incorporated · Long Beach, California and 14 other locations · NCT07144150

• ZENFLEX Pro™ drug-eluting stent for femoropopliteal artery blockages

  This will test the ZENFLEX Pro drug-eluting stent to open narrowed or blocked femoropopliteal arteries in adults with symptomatic peripheral arterial disease.

  Recruiting Mdcecro LLC · Chrzanów, Chrzanow · NCT07122167

• Vascular registry pilot for peripheral arterial disease

  Trying whether taking two antiplatelet medicines for six months instead of one month helps keep treated leg arteries open after lower extremity endovascular revascularization in people with peripheral arterial disease.

  Recruiting at 2 sites Phase 4 Corewell Health West · Detroit, Michigan and 1 other locations · NCT07076082

• Pressure and flow measurements during peripheral artery procedures

  This will try pressure (FFR) and flow (VFR) measurements during procedures to see if they help people with peripheral artery disease or critical limb ischemia get the right treatment and better outcomes.

  Recruiting University Hospital of Patras · Pátrai · NCT07052435

• Evaluating full-body imaging technology for skin disease detection

  This study is testing a new full-body imaging technology to see if it can help doctors better detect and monitor skin diseases like skin cancer and eczema.

  Recruiting at 3 sites HJN Sverige AB/Neko Health · Stockholm and 2 other locations · NCT06989216

• Non-invasive imaging to measure skin composition and structure

  This study is testing a new non-invasive imaging technology to see if it can accurately measure different components and structures of skin in people visiting their primary care doctor, especially those at higher risk for heart issues or diabetes.

  Recruiting at 3 sites HJN Sverige AB/Neko Health · Stockholm and 2 other locations · NCT06976073

• Noninvasive tool for diagnosing Peripheral Arterial Disease

  This study is testing a new ultrasound tool to see if it can help diagnose Peripheral Arterial Disease earlier and track how well treatments are working for people with the condition.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06952543

• Evaluating the impact of stress on heart events in patients with peripheral artery disease

  This study looks at how different ways of measuring stress affect heart problems in people with peripheral artery disease.

  Recruiting University Hospital, Essen · Essen · NCT06887101

• Evaluating VTE Prevention with Rivaroxaban and Aspirin After Lower Limb Surgery

  This study is testing if taking a combination of rivaroxaban and aspirin after lower limb surgery can help prevent blood clots better than just taking aspirin alone.

  Recruiting Phase 4 Science Valley Research Institute · Pernambuco, Pernambuco · NCT06873321

• Assessing Peripheral Arterial Disease in Patients with Deep Vein Thrombosis

  This study looks at how common Peripheral Arterial Disease is in people with unprovoked Deep Vein Thrombosis and compares it to those with other types of DVT to see how their heart health is related.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Bologna · NCT06806540

• Integrated care for older patients with atrial fibrillation

  This study is testing a new team-based care approach for older patients with atrial fibrillation and other health issues to see if it helps them manage their condition better than regular care.

  Recruiting at 50 sites Heart Care Foundation · Haskovo and 49 other locations · NCT06775028

• Evaluating the Oscar Catheter for Treating Peripheral Arterial Disease

  This study is testing a new catheter to see if it can safely help people with blocked arteries in their legs feel better after treatment.

  Recruiting at 2 sites Biotronik AG · Graz and 15 other locations · NCT06758921

• Exercise therapy before and after stenting for leg artery disease

  This study tests whether exercise programs before and after stenting can help people with leg artery disease feel better and recover faster.

  Recruiting Palo Alto Veterans Institute for Research · Palo Alto, California · NCT06566976

• Assessing temperature changes in legs before and after vascular procedures

  This study is testing if measuring leg temperatures with a thermal camera before and after surgery can help predict how well patients with peripheral arterial disease will do after their procedures.

  Recruiting at 3 sites University Hospitals Cleveland Medical Center · Beachwood, Ohio and 2 other locations · NCT06544135

• Comparing enteric-coated and plain aspirin to reduce heart disease risks from air pollution

  This study is testing whether enteric-coated or plain low-dose aspirin can better help people with heart disease reduce their risks from air pollution, along with providing tips to stay healthy.

  Recruiting Rajaie Cardiovascular Medical and Research Center · Tehran, Tehran Province · NCT06541691

• Using Sperstent® for treating residual lesions in leg arteries

  This study is testing whether the Sperstent® can help people with leftover blockages in their leg arteries feel better compared to another type of stent called Everflex®.

  Recruiting at 3 sites FrontAce Scientific Co., Ltd · Beijing, Beijing Municipality and 11 other locations · NCT06539689

• High-frequency spinal cord stimulation for leg pain from diabetic neuropathy and peripheral artery disease

  This study will test whether high-frequency spinal cord stimulation can reduce walking-related leg pain in people with painful diabetic neuropathy and peripheral arterial disease who responded to a temporary SCS trial.

  Recruiting University of Nebraska · Omaha, Nebraska · NCT06480786

• Carnosine supplementation for improving walking ability in patients with peripheral arterial disease

  This study is testing if taking carnosine for six months can help people with peripheral arterial disease walk better.

  Recruiting Phase 1/2 University of Louisville · Louisville, Kentucky and 2 other locations · NCT06480760

• Passive stretching to improve walking in patients with peripheral artery disease

  This study tests if passive stretching of the calf muscles can help people with peripheral artery disease walk better by improving blood flow and reducing inflammation.

  Recruiting Phase 2 University of Wisconsin, La Crosse · La Crosse, Wisconsin · NCT06420752

• Personalised multicomponent exercise program for peripheral arterial disease

  This trial tests whether a personalised, continuously monitored exercise program using heart-rate and muscle-oxygen sensors can help people with peripheral arterial disease and intermittent claudication walk farther and have less leg pain.

  Recruiting at 3 sites University of Trás-os-Montes and Alto Douro · Vila Real and 2 other locations · NCT06410521

• MitoQ treatment for improving leg pain in peripheral artery disease

  This study is testing if a treatment called MitoQ can help people with peripheral artery disease feel less leg pain while walking and improve their overall daily activities.

  Recruiting University of Nebraska · Omaha, Nebraska · NCT06409949

• Using Fisetin to Improve Walking in Patients with Peripheral Arterial Disease

  This study is testing if Fisetin can help people with peripheral artery disease walk better by reducing certain old cells in their bodies.

  Recruiting Phase 2 Northwestern University · Chicago, Illinois · NCT06399809

• Using the Golazo® Peripheral Atherectomy System for treating Peripheral Arterial Disease

  This study is testing a new device called the Golazo® Peripheral Atherectomy System to see if it can safely and effectively treat people with symptoms of peripheral arterial disease.

  Recruiting at 17 sites Nipro Vascular Innovations Americas, Inc · Scottsdale, Arizona and 19 other locations · NCT06321575

• Effects of a medication on blood vessel function and walking ability in people with peripheral artery disease

  This study is testing if a medication called diroximel fumarate can help improve blood vessel function and walking ability in people aged 50-75 with peripheral artery disease.

  Recruiting Early Phase 1 University of Nebraska · Omaha, Nebraska · NCT06319339

• Fuzzy Wale compression stockinet to promote healing after a below-knee (transtibial) amputation

  This will test whether a Fuzzy Wale compression stockinet helps adults with peripheral arterial disease heal faster after a below-knee amputation compared with the usual compression stocking.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06308562

• Evaluating a new procedure for patients with severe limb ischemia who have no other options

  This study is testing a new procedure to see if it can help patients with severe leg circulation problems who have run out of other treatment options.

  Recruiting at 6 sites EndoCore Lab s.r.l. · Ancona, Ancona and 8 other locations · NCT06277362

• Using mobile health data to improve recovery after bypass surgery for leg ischemia

  This study is testing if using health data from a smartwatch can help older patients recover better and move more easily after bypass surgery for leg problems.

  Recruiting University of Florida · Gainesville, Florida · NCT06263322

• Evaluating coronary revascularization in patients with peripheral artery disease

  This study is testing if adding a heart procedure to standard treatment can help people with peripheral artery disease avoid serious heart problems after they've had surgery on their legs.

  Recruiting Pauls Stradins Clinical University Hospital · Riga · NCT06250790

• Assessing a new tool for evaluating patients with lower extremity peripheral arterial disease

  This study is testing a new questionnaire to see if it helps better understand the needs of people with lower extremity peripheral arterial disease.

  Recruiting RenJi Hospital · Shanghai, Shanghai Municipality · NCT06223217

• Creating AI tools to predict vascular disease risk and progression

  This study is trying to create smart computer tools that can predict the risk and progression of vascular diseases like abdominal aortic aneurysm and peripheral arterial disease by looking at medical images and patient history.

  Recruiting at 6 sites Amsterdam UMC, location VUmc · Helsinki and 5 other locations · NCT06206369

• Early angioplasty for diabetic foot syndrome

  This study is testing if getting a quick angioplasty after being diagnosed with diabetic foot ulcers helps heal the wounds better than waiting for the procedure.

  Recruiting Heinrich-Heine University, Duesseldorf · Düsseldorf · NCT06124586

• Comparing lithotripsy and standard preparation for treating femoropopliteal artery disease

  This study is testing whether a new treatment called lithotripsy is safer and more effective than standard methods for helping people with femoropopliteal artery disease.

  Recruiting University of Leipzig · Leipzig, Saxony · NCT06112171

• Exercise and beetroot juice for improving walking in patients with PAD

  This study is testing whether combining treadmill and home exercises with beetroot juice can help older patients with peripheral artery disease walk farther and feel better.

  Recruiting at 3 sites Phase 3 Northwestern University · Chicago, Illinois and 2 other locations · NCT06032065

• Exploring the links between oral bacteria, muscle blood flow, and fitness levels

  This study is trying to see how oral bacteria and fitness levels affect blood flow to muscles in people.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT06009276

• Using Smart Flex Stent to Treat Long Femoropopliteal Artery Lesions

  This study is testing if the Smart Flex Stent can safely help people with Peripheral Arterial Disease who have long blockages in their leg arteries feel better and improve their blood flow.

  Recruiting RenJi Hospital · Shanghai, Shanghai Municipality · NCT05894863

• Using Shockwave technology to treat calcified iliac access for aortic procedures

  This study is testing if a special shockwave device can help doctors safely deliver large aortic devices through patients' blocked iliac arteries.

  Recruiting at 2 sites EndoCore Lab s.r.l. · Ancona, Ancona and 5 other locations · NCT05880641

• Registry for the Pounce Thrombectomy System in treating blood clots

  This study looks at how well the Pounce Thrombectomy System works for removing blood clots in patients with peripheral artery disease and acute limb ischemia who have had a specific procedure done.

  Recruiting at 7 sites SurModics, Inc. · Peoria, Illinois and 8 other locations · NCT05868161

• Using Stempeucel® to treat critical limb ischemia in patients with peripheral arterial disease

  This study is testing if a stem cell treatment called Stempeucel® can help Malaysian patients with critical limb ischemia feel better and heal faster.

  Recruiting Phase 4 Cell Biopeutics Resources Sdn Bhd · Kuala Lumpur · NCT05854641

• Comparison of a new endoprosthesis to traditional stenting for iliac artery disease

  This study is testing a new type of stent for people with iliac artery disease to see if it works better than the traditional metal stents in improving blood flow and relieving symptoms.

  Recruiting at 40 sites W.L.Gore & Associates · Little Rock, Arkansas and 42 other locations · NCT05811364

• Using ultrasound therapy to treat severe leg ulcers from poor blood flow

  This study is testing if using ultrasound therapy can help heal severe leg ulcers in people with poor blood flow caused by peripheral arterial disease.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT05749250

• Investigation of Renzan Stent for treating leg artery disease in Tuscany

  This study is testing a new type of stent to see if it can safely help people with leg artery disease feel better and improve their blood flow.

  Recruiting Azienda Ospedaliera Universitaria Senese · Siena · NCT05701293

• Comparing high-intensity and low-to-moderate exercise for patients with peripheral artery disease

  This study is testing whether high-intensity workouts or gentler exercises help people with peripheral artery disease walk better and feel healthier.

  Recruiting Centre Hospitalier Universitaire Vaudois · Lausanne, Canton of Vaud · NCT05612945

• Ewing below-knee amputation versus standard below-knee amputation for Veterans with peripheral artery disease

  This trial will randomize Veterans with PAD who need a below-knee amputation to try the Ewing amputation or the standard below-knee amputation to see which leads to better walking, less pain, and improved balance.

  Recruiting at 3 sites VA Office of Research and Development · Decatur, Georgia and 2 other locations · NCT05437562

• Evaluating the effectiveness of endovascular treatment for aortoiliac occlusive disease

  This study is testing how well a new endovascular treatment works for people with aortoiliac occlusive disease over the long term.

  Recruiting Shanghai Zhongshan Hospital · Shanghai · NCT05391815

• Minimally invasive treatment for severe leg blood flow issues

  This study is testing a new, less invasive treatment for people with severe leg blood flow problems who can't have regular surgery to see if it helps improve their condition.

  Recruiting at 8 sites LimFlow, Inc. · La Jolla, California and 29 other locations · NCT05313165

• Evaluating Shockwave Intravascular Lithotripsy for Calcified Femoral Arteries

  This study is testing if a new shockwave treatment can help people with blocked femoral arteries due to calcium buildup feel better and improve their health.

  Recruiting Yale University · New Haven, Connecticut and 1 other locations · NCT05145478

• Comparing a new drug-eluting balloon to standard balloon angioplasty for treating severe leg artery disease

  This study tests if a new drug-coated balloon treatment can help people with severe leg artery disease feel better compared to the standard balloon procedure.

  Recruiting at 41 sites M.A. Med Alliance S.A. · Chandler, Arizona and 47 other locations · NCT05055297

• Using a bioresorbable scaffold to treat severe leg artery disease

  This study is testing a new dissolvable device to see if it can help people with severe leg artery disease improve blood flow and reduce leg pain.

  Recruiting at 6 sites R3 Vascular Inc. · Graz and 6 other locations · NCT04912323

• Adapted Physical Activity for People with Lower Limb Peripheral Artery Disease

  This study tests a targeted exercise program to improve walking ability in people with peripheral artery disease.

  Recruiting Centre Hospitalier le Mans · Le Mans · NCT04800276

• Using low dose colchicine to reduce vascular events in patients with peripheral artery disease

  This study is testing if a low dose of colchicine can help people with peripheral artery disease avoid serious heart and leg problems compared to a placebo.

  Recruiting at 85 sites Phase 3 Population Health Research Institute · New Haven, Connecticut and 85 other locations · NCT04774159

• Treatment for patients with blocked femoropopliteal arteries using a new vascular scaffold

  This study is testing a new device to see if it can help people with blocked leg arteries feel better and improve their blood flow.

  Recruiting at 8 sites Efemoral Medical, Inc. · Sydney, New South Wales and 7 other locations · NCT04584632

• Evaluating care for patients with popliteal artery aneurysm

  This study is trying to see how different types of care before and after surgery can affect the health and quality of life for people with popliteal artery aneurysms.

  Recruiting at 2 sites Karolinska University Hospital · Gothenburg and 1 other locations · NCT04188808

• Management of severe limb ischaemia and its outcomes

  This study looks at patients with severe limb ischaemia to see how often they need major amputations within a year and how factors like frailty and heart health affect their outcomes.

  Recruiting University of Leicester · Leicester, Leicestershire · NCT04027244

• Research on health inequality and genetic disparity in cardiovascular diseases

  This study is trying to understand how health differences and genetics affect heart diseases in people from various ethnic backgrounds in the UK to help improve treatments for everyone.

  Recruiting Future Genetics Limited · Wolverhampton, West Midlands · NCT03987633

• Isometric handgrip training for patients with peripheral artery disease

  This study is testing whether a specific handgrip exercise can help lower blood pressure in people with high blood pressure and peripheral artery disease.

  Recruiting University of Nove de Julho · São Paulo, São Paulo and 1 other locations · NCT03663777

• Improving blood flow in limbs using ultrasound

  This study is testing whether a special ultrasound technique can improve blood flow in the limbs of people with peripheral arterial disease.

  Recruiting Oregon Health and Science University · Portland, Oregon · NCT03195556

• Registry of Chronic Wounds and Ulcers

  This study collects information from patients with chronic wounds and ulcers to see how well different treatments are working and to improve the quality of wound care.

  Recruiting U.S. Wound Registry · The Woodlands, Texas · NCT02280733

• Registry for evaluating treatments in patients with Peripheral Arterial Disease

  This study is trying to see how well different treatments work for people with Peripheral Arterial Disease by looking at data from 14,000 patients who have had procedures to improve blood flow.

  Recruiting at 7 sites Baylor Research Institute · Little Rock, Arkansas and 23 other locations · NCT01904851

NIH-funded research (34)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Contrast-free ultrasound to measure tiny blood flow in legs to help PAD

  A noninvasive ultrasound approach uses new metrics to quantify microvascular blood flow in the lower leg to aid in diagnosing and managing peripheral arterial disease.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11411380

• Understanding Spp1+ Macrophages and Muscle Healing in Peripheral Artery Disease

  This grant supports a physician-scientist in Duke's vascular surgery program to study how a specific macrophage type called Spp1+ macrophages affect muscle healing in people with peripheral artery disease.

  NIH research Duke University · Durham, United States · NIH-11401127

• Reprogrammed Monocytes for improved blood vessel growth in leg PAD

  A study to see if reprogramming a patient’s own monocytes can boost new blood vessel growth and improve limb health in people with peripheral artery disease.

  NIH research University of South Florida · Tampa, United States · NIH-11379880

• Targeting Dhcr24 in monocytes to boost blood vessel growth in critical limb ischemia

  This grant explores a new way to help people with severe leg artery disease by making certain immune cells grow more blood vessels to improve blood flow.

  NIH research University of South Florida · Tampa, United States · NIH-11376123

• Carnosine and improved leg function in peripheral artery disease

  This grant tests whether taking carnosine can improve leg function for people with peripheral artery disease.

  NIH research University of Louisville · Louisville, United States · NIH-11364175

• Understanding how CKD worsens leg artery disease at the cellular level

  This grant explores why people with chronic kidney disease have faster, more severe peripheral artery disease and how specific cellular pathways contribute to worse blood flow and limb risk.

  NIH research University of Florida · Gainesville, United States · NIH-11361100

• Biocarpet: a biodegradable implant for blocked leg arteries

  A new biodegradable, flexible implant that molds to your artery aims to keep blood flowing in people with peripheral artery disease.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11327516

• Home exercise program with smartphone support and remote monitoring for peripheral artery disease

  This program helps adults with peripheral artery disease use a smartphone and remote monitoring to do guided home exercises to reduce leg pain and improve walking.

  NIH research Veterans Health Administration · Decatur, UNITED STATES · NIH-11327253

• Injectable engineered scaffold to improve blood flow and muscle health in legs with peripheral artery disease

  Testing an injectable engineered material designed to help improve blood flow and heal damaged leg muscle in people with peripheral artery disease.

  NIH research Washington University · Saint Louis, United States · NIH-11319847

• Preventing amputations in rural patients with diabetes and poor circulation

  This study is working on a friendly program to help people in rural West Virginia with diabetes and circulation problems avoid amputations by creating community-based solutions that fit their needs.

  NIH research Duke University · Durham, United States · NIH-11294631

• Repairing diabetic stem cells to improve leg blood flow and muscle and nerve healing

  This project aims to fix patients' own diabetic stem cells so they can better heal muscle and nerve damage from peripheral artery disease.

  NIH research Cincinnati VA Medical Center Research · Cincinnati, United States · NIH-11247938

• How muscle reflexes and antioxidants affect walking pain and blood pressure in peripheral artery disease

  This project seeks to find out whether blocking a muscle nerve reflex and boosting the Nrf2 antioxidant system can reduce blood pressure spikes, improve muscle blood flow, and ease walking pain for people with peripheral artery disease.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11237160

• A modified below-knee amputation to help veterans with diabetes or poor leg circulation walk and have less pain

  Testing a modified below-knee amputation called the Ewing amputation in veterans with diabetes or peripheral arterial disease to improve walking with a prosthesis and reduce pain.

  NIH research Cincinnati VA Medical Center Research · Cincinnati, United States · NIH-11222664

• Investigating genetic factors affecting limb health in African Americans with peripheral artery disease

  This study is looking at how genes affect leg health in African Americans with peripheral artery disease, and it wants to find out how different forms of the disease show up, so we can discover new ways to help improve blood flow and prevent serious problems.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11215039

• Lab-grown blood vessel cells to help legs with poor circulation from peripheral artery disease

  Trying a special type of stem-cell–derived blood vessel cell, improved for mitochondrial health, to restore blood flow and reduce limb loss in people with severe peripheral artery disease.

  NIH research Veterans Admin Palo Alto Health Care Sys · Palo Alto, United States · NIH-11206885

• Understanding Carnosine's Role in Leg Artery Disease

  This project explores if a supplement called carnosine can help improve leg function for people with peripheral arterial disease.

  NIH research University of Louisville · Louisville, United States · NIH-11169978

• Contrast-free ultrasound to measure blood flow in the lower leg

  A new dye-free ultrasound method will measure tiny blood flow changes in the calf muscles of people with peripheral artery disease.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11159751

• New nanoparticles to improve blood flow in patients with peripheral arterial disease

  This study is testing new tiny particles that can help grow new blood vessels in people with peripheral arterial disease (PAD), making it easier for them to heal and improve blood flow without needing surgery.

  NIH research University of Texas Arlington · Arlington, United States · NIH-11083040

• New treatment approach for improving blood flow in patients with peripheral artery disease

  This study is working on a new injectable treatment made from special materials to help improve blood flow and blood vessel growth for people with peripheral artery disease (PAD), aiming to make existing therapies work better or even serve as a standalone option.

  NIH research Washington University · Saint Louis, United States · NIH-11054610

• Improving the function of stem cells in diabetic patients with leg problems

  This study is looking at ways to help improve the healing power of special cells in people with diabetes who have trouble with blood flow in their legs, so they can walk better and get back to their daily activities.

  NIH research Veterans Health Administration · Decatur, UNITED STATES · NIH-11052120

• Using patient feedback tools to improve care for peripheral artery disease

  This study is looking at how to use feedback from people with peripheral artery disease to make their treatment better and improve communication with doctors, so that patients' experiences and needs are taken into account in their care.

  NIH research University of Utah · Salt Lake City, United States · NIH-11051760

• Reprogrammed immune cells help improve blood vessel growth in patients with severe leg artery disease.

  This study is looking at how changing certain immune cells in people with critical limb ischemia can help grow new blood vessels and improve blood flow in their legs, especially for those who can't have regular surgery.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11019879

• Investigating how exercise affects blood flow and pain in patients with peripheral arterial disease

  This study is looking at how a strong exercise response affects blood flow and pain in people with peripheral arterial disease (PAD), which causes leg pain when you move, and aims to find ways to help improve blood flow and reduce that pain during exercise.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-10999419

• Improving blood vessel growth in patients with severe leg artery disease

  This study is looking at how changing certain immune cells in people with critical limb ischemia can help grow new blood vessels and improve blood flow, which might reduce the need for amputation and promote healing.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-10992647

• Understanding how certain immune cells affect muscle healing in patients with poor blood flow.

  This study is looking at how a special type of immune cell affects muscle healing in people with peripheral arterial disease (PAD), with the goal of finding new ways to help improve recovery and prevent limb loss.

  NIH research Duke University · Durham, United States · NIH-10984305

• A new ultrasound technique to measure blood flow in patients with leg artery disease

  This study is testing a new, safe way to use ultrasound to check blood flow in the legs of people with peripheral arterial disease (PAD), helping doctors understand how well blood is moving in smaller vessels and potentially leading to better care for patients.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-10941852

• Using stem cells to improve treatment for peripheral arterial disease in veterans

  This study is testing a new treatment for veterans with peripheral arterial disease (PAD) that uses special cells to help improve blood flow in their legs and prevent serious problems like amputations.

  NIH research Veterans Health Administration · Decatur, UNITED STATES · NIH-10924860

• Investigating a new amputation technique for veterans with peripheral arterial disease

  This study is looking at a new type of surgery called Ewing amputation for veterans with diabetes and peripheral arterial disease who need below-knee amputations, to see if it helps them recover better and walk more easily with prosthetics.

  NIH research Veterans Health Administration · Decatur, UNITED STATES · NIH-10919765

• A new biodegradable device for treating peripheral arterial disease

  This study is testing a new device called the Biocarpet, which is designed to help people with peripheral arterial disease (PAD) by providing a gentle support for their blood vessels, with the hope of improving their treatment results and reducing complications.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10914995

• Improving home exercise therapy for patients with peripheral arterial disease using mobile health technology

  This study is looking to make it easier for people with peripheral arterial disease, especially veterans, to do their exercise therapy at home using smartphone tools, so they can improve their mobility and quality of life without the hassle of traveling to a clinic.

  NIH research Veterans Health Administration · Decatur, UNITED STATES · NIH-10909986

• New treatments for Peripheral Arterial Disease related to diabetes

  This study is looking at new ways to help people with Peripheral Arterial Disease (PAD) and diabetes by exploring how exercise affects muscle health, especially for those who can't exercise because of pain, to find better treatments that improve blood flow and muscle function.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-10892850

• Understanding how kidney disease affects blood flow in the legs

  This study is looking at how chronic kidney disease might make symptoms of peripheral artery disease worse, and it aims to find new ways to help patients feel better and improve their blood flow.

  NIH research University of Florida · Gainesville, United States · NIH-10745646

• Mapping energy metabolism in patients with peripheral arterial disease using MRI.

  This study is exploring a new way to check how well your muscles are working if you have peripheral arterial disease (PAD) by using a special type of MRI that looks at energy levels in your muscles, which could help doctors understand your condition better and find the right treatments for you.

  NIH research Hugo W. Moser Res Inst Kennedy Krieger · Baltimore, United States · NIH-10677775

• Developing a wearable ultrasound device to treat peripheral arterial disease

  This study is testing a special wearable ultrasound device that helps improve blood flow for people with peripheral arterial disease (PAD), making it easier and more convenient for patients to get treatment and potentially avoid serious complications.

  NIH research Vibrato Medical, INC. · Newport Coast, United States · NIH-10603253

Related topics

Quick answers

How many Peripheral Arterial Disease clinical trials are recruiting right now?

72, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 41 countries. The most sites are in United States (32 trials), Italy (10 trials), Germany (8 trials), United Kingdom (7 trials), China (7 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 3: 3, Phase 4: 3, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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