MitoQ treatment for improving leg pain in peripheral artery disease
Official title: MitoQ Treatment of Claudication: Myofiber and Micro-vessel Pathology
Run by University of Nebraska · NCT06409949 · Data updated 2026-11-12
This study is testing if a treatment called MitoQ can help people with peripheral artery disease feel less leg pain while walking and improve their overall daily activities.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 21 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | University of Nebraska Academic / other |
| Locations | 1 site (Omaha, Nebraska) |
| Status | Recruiting |
| Started | June 1, 2023 |
| Main results expected | October 2026 |
| Study ends | June 2027 |
| Registry record updated | February 24, 2026 |
| Trial ID | NCT06409949 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals with a documented history of chronic claudication and stable cardiovascular risk factors.
✕Probably not a fit
Patients with severe PAD symptoms, such as rest pain or tissue loss, or those whose walking capacity is limited by other conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This research investigates the effects of MitoQ, taken for six months, on individuals with peripheral artery disease (PAD) who experience intermittent claudication, or leg pain while walking. The study aims to assess improvements in walking ability, daily activity levels, and overall quality of life. Researchers will analyze muscle tissue samples, blood tests, mitochondrial health, and blood flow in the legs to determine the efficacy of MitoQ in enhancing muscle function and reducing symptoms associated with claudication.
Why it matters
Potential benefit: If successful, this treatment could significantly improve the walking ability and quality of life for patients suffering from claudication due to PAD.
How similar studies have gone: While the specific use of MitoQ in this context may be novel, similar studies targeting mitochondrial function in PAD have shown promising results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. a positive history of chronic claudication 2. exercise-limiting claudication established by history and direct observation during a screening walking test administered by the evaluating vascular surgeon 3. documented lower extremity arterial occlusive disease based on ankle/brachial index measurements and/or arterial imaging 4. stable blood pressure, lipid and diabetes regimens and risk factor control for 6 weeks. Exclusion Criteria: 1. rest pain or tissue loss due to PAD (Fontaine stage III and IV) 2. acute lower extremity ischemic event 3. walking capacity significantly and primarily limited by conditions other than claudication including leg (joint/musculoskeletal, neurologic) and systemic (heart, lung disease) pathology.
Where it's running
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VA Medical Center
Omaha, Nebraska, United States Recruiting
Study contacts
- Principal investigator: Iraklis Pipinos, MD — University of Nebraska
- Study coordinator: Holly DeSpiegelaere, BSN RN CCRC
- Email: Holly.DeSpiegelaere@va.gov
- Phone: 402-995-4171
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.