Noninvasive tool for diagnosing Peripheral Arterial Disease
Official title: Ultrasound Perfusion Estimation for Assessment of PAD
Run by Mayo Clinic · NCT06952543 · Data updated 2026-11-12
This study is testing a new ultrasound tool to see if it can help diagnose Peripheral Arterial Disease earlier and track how well treatments are working for people with the condition.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 400 (estimated) |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Status | Recruiting |
| Started | March 14, 2025 |
| Main results expected | May 30, 2029 |
| Study ends | August 30, 2029 |
| Registry record updated | May 5, 2026 |
| Trial ID | NCT06952543 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and older with symptoms of claudication and suspected PAD, as well as healthy volunteers aged 18-75 with no significant health issues.
✕Probably not a fit
Patients with gangrene, recent surgeries, or other serious leg conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to develop a new noninvasive ultrasound imaging tool for the early diagnosis of Peripheral Arterial Disease (PAD). It will also monitor disease progression and response to treatment in patients diagnosed with PAD. The study will involve both patient volunteers with symptoms of claudication and healthy volunteers for comparison. Participants will undergo ultrasound imaging to assess blood flow and perfusion in the affected areas.
Why it matters
Potential benefit: If successful, this tool could lead to earlier diagnosis and better management of Peripheral Arterial Disease, improving patient outcomes.
How similar studies have gone: Other studies have shown promise in using ultrasound imaging for vascular assessments, indicating potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Patient volunteers: * Male and Female, ages 18 years old and up * Symptom of claudication and suspected for PAD * Scheduled for vascular testing. Healthy volunteers: * Male and female, ages 18-75 years old and up * Normal BMI * No history of smoking, cardiovascular disease, or diabetes. Exclusion Criteria: Patient volunteers: * Patients with gangrene * Patients having surgery or stent * Patients with ulcer on their leg * Any health condition that does not allow proper use of ultrasound scanning * People considered in "vulnerable" populations. Healthy volunteers: * Include volunteers with BMI not more than 30 * No history of smoking * No history of (diabetes, hypertension, cardiovascular diseases) * People considered in "vulnerable" populations.
Where it's running
-
Mayo Clinic in Rochester
Rochester, Minnesota, United States Recruiting
Study contacts
- Principal investigator: Azra Alizad — Mayo Clinic
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Predictors of Major Adverse Limb Events After Iliac Artery Stenting
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Radial and Ulnar Access in Vascular Interventions Registry
This registry tests how often radial or ulnar artery access is used and what happens afterward in routine vascular procedures.
-
Remote versus in-person 30-second sit-to-stand testing for people with peripheral artery disease
This project will test whether doing the 30-second sit-to-stand test by video works as well as doing it in person for adults aged 18–65 with Fontaine stage I–II peripheral artery disease who have a smartphone.
-
Imaging plaque activity across the body in people with symptomatic peripheral arterial disease
This project will use whole-body PET-CT and CT angiography with several tracers to see if imaging can detect inflammation, microcalcification, and clot activity in people with symptomatic peripheral arterial disease.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.