Condition

Diabetic Foot clinical trials and research

• 25Clinical trials
• 49NIH research projects
• 8Countries

Newest Diabetic Foot clinical trials

All recruiting trials (25)

• Miro3D Wound Matrix for Diabetic Foot Ulcers

  This study tests whether adding Miro3D Wound Matrix to standard care helps healing diabetic foot ulcers in adults.

  Recruiting at 6 sites Reprise Biomedical, Inc. · Phoenix, Arizona and 13 other locations · NCT07632001

• Topical Capsadyn (palmitated capsaicin) for diabetic neuropathic foot pain

  This study will test whether a topical Capsadyn cream can reduce foot pain in adults with diabetic peripheral neuropathy.

  Recruiting Early Phase 1 Carilion Clinic · Roanoke, Virginia · NCT07260656

• Single-layer placental graft plus standard care for stubborn diabetic foot ulcers

  This trial will try a single-layer placental-based graft together with usual wound care for adults whose diabetic foot ulcers did not heal after standard treatment in an earlier trial.

  Recruiting Phase 4 Applied Biologics, LLC · Hollywood, Florida · NCT07159282

• Using human placental membrane wraps with regular wound care to help heal stubborn diabetic foot and venous leg ulcers

  This trial tests whether adding one of four human placental membrane wraps to standard wound care helps people with nonhealing diabetic foot or venous leg ulcers heal faster and more completely than standard care alone.

  Recruiting Phase 4 BioLab Holdings · Philidelphia, Pennsylvania · NCT07089602

• Evaluating full-body imaging technology for skin disease detection

  This study is testing a new full-body imaging technology to see if it can help doctors better detect and monitor skin diseases like skin cancer and eczema.

  Recruiting at 3 sites HJN Sverige AB/Neko Health · Stockholm and 2 other locations · NCT06989216

• Non-invasive imaging to measure skin composition and structure

  This study is testing a new non-invasive imaging technology to see if it can accurately measure different components and structures of skin in people visiting their primary care doctor, especially those at higher risk for heart issues or diabetes.

  Recruiting at 3 sites HJN Sverige AB/Neko Health · Stockholm and 2 other locations · NCT06976073

• Evaluating new treatments for nonhealing diabetic foot and venous leg ulcers.

  This study is testing whether new treatments for stubborn diabetic foot and leg ulcers can help people heal better when combined with standard care compared to just standard care alone.

  Recruiting Phase 4 Tiger Biosciences, LLC. · Monroeville, Pennsylvania · NCT06826339

• Evaluating human placental membrane products for treating nonhealing diabetic foot and venous leg ulcers

  This study is testing whether using human placental products along with regular care can help people with stubborn diabetic foot and leg ulcers heal better.

  Recruiting C5 Biomedical · Metairie, Louisiana · NCT06674980

• Evaluating a new placental-based treatment for diabetic foot ulcers

  This study is testing if a new placental treatment can help adults with hard-to-heal diabetic foot ulcers get better faster when used alongside regular care.

  Recruiting Applied Biologics, LLC · Clinton Township, Michigan · NCT06564831

• Using dehydrated human amnion membrane to treat nonhealing diabetic foot ulcers

  This study is testing if adding dehydrated human amnion membrane to regular care can help people with stubborn diabetic foot ulcers heal better.

  Recruiting Axolotl Biologix · Thousand Oaks, California · NCT06550596

• Lifestyle intervention to prevent diabetic foot ulcers from coming back

  This study tests a lifestyle program to help people who have healed diabetic foot ulcers take better care of their feet and manage their diabetes to prevent the ulcers from coming back.

  Recruiting at 2 sites University of Southern California · Downey, California and 2 other locations · NCT06487780

• Evaluating new treatments for hard-to-heal diabetic foot ulcers

  This study is testing if new treatments using special placental products can help heal tough diabetic foot ulcers better than the usual care alone.

  Recruiting at 3 sites StimLabs · Omaha, Nebraska and 4 other locations · NCT06449638

• Tailored lifestyle intervention for diabetic foot ulcer care

  This study is testing a new online program led by occupational therapists to help people with diabetic foot ulcers better manage their care and follow treatment plans over 8 weeks.

  Recruiting University of Southern California · Los Angeles, California · NCT06278935

• Evaluating a new procedure for patients with severe limb ischemia who have no other options

  This study is testing a new procedure to see if it can help patients with severe leg circulation problems who have run out of other treatment options.

  Recruiting at 6 sites EndoCore Lab s.r.l. · Ancona, Ancona and 8 other locations · NCT06277362

• Understanding immune cells in diabetic foot ulcers

  This study looks at how immune cells behave in people with diabetes who have foot ulcers to see if understanding them can help improve healing for those with chronic wounds.

  Recruiting Karolinska Institutet · Huddinge, Stockholm County · NCT06154915

• Early angioplasty for diabetic foot syndrome

  This study is testing if getting a quick angioplasty after being diagnosed with diabetic foot ulcers helps heal the wounds better than waiting for the procedure.

  Recruiting Heinrich-Heine University, Duesseldorf · Düsseldorf · NCT06124586

• Identifying biomarkers for healing diabetic foot ulcers

  This study is trying to find specific markers in the body that can help predict which diabetic foot ulcers are likely to heal, so doctors can better manage treatment for patients with these wounds.

  Recruiting at 8 sites University of Michigan · Tucson, Arizona and 8 other locations · NCT06104969

• Monitoring insoles for preventing diabetic foot ulcers

  This study is testing if special insoles that monitor foot temperature and pressure can help people with diabetes avoid foot ulcers better than regular foot care.

  Recruiting Royal Free Hospital NHS Foundation Trust · London · NCT06084052

• Wearable Insoles to Help Prevent Diabetic Foot Ulcers

  This study tests Orpyx sensory insoles added to standard care to see if they reduce diabetic foot ulcers in high-risk adults with neuropathy.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT05950659

• Optimizing diabetes foot care using eHealth tools

  This study is testing a new way to use digital tools to help people with diabetes take better care of their feet and prevent foot ulcers.

  Recruiting Sahlgrenska University Hospital · Gothenburg · NCT05692778

• Using stem cells from fat to treat diabetic foot ulcers

  This study is testing if using stem cells from fat, along with a special blood product, can help heal chronic foot ulcers in people with diabetes.

  Recruiting Phase 1 University of the Punjab · Lahore, Punjab Province · NCT05610865

• Understanding biofilm infections in diabetic foot ulcers

  This study looks at how biofilm infections in diabetic foot ulcers affect healing and whether they make wounds more likely to come back.

  Recruiting at 2 sites University of Pittsburgh · Tucson, Arizona and 1 other locations · NCT05172089

• Exploring the role of skin bacteria in diabetic skin conditions

  This study is trying to see how the bacteria on the skin of diabetic patients differ from those without diabetes to help find ways to prevent foot problems.

  Recruiting Nanfang Hospital, Southern Medical University · Guangzhou, Guangdong · NCT04916457

• Using hyperbaric oxygen therapy after lower limb amputation

  This study is testing if adding hyperbaric oxygen therapy after a leg amputation can help patients heal better and reduce the chances of needing more amputations.

  Recruiting at 2 sites Oslo University Hospital · Oslo and 1 other locations · NCT03594344

• Registry of Chronic Wounds and Ulcers

  This study collects information from patients with chronic wounds and ulcers to see how well different treatments are working and to improve the quality of wound care.

  Recruiting U.S. Wound Registry · The Woodlands, Texas · NCT02280733

NIH-funded research (newest 40 of 49)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Improving Diabetic Foot Ulcer Offloading with User-Friendly Cast Walker Design

  A small pilot study to see how different removable cast walker designs affect daily use and healing of diabetic foot ulcers.

  NIH research Rosalind Franklin Univ of Medicine & Sci · North Chicago, United States · NIH-11640036

• Home-based exercise to help Veterans recover after healed diabetic foot ulcers

  A home-based exercise program for Veterans who recently healed from a diabetic foot ulcer to improve walking and daily function.

  NIH research Baltimore VA Medical Center · Baltimore, United States · NIH-11511696

• How Medicaid Coverage Changes Diabetic Foot Care in Safety-Net Patients

  This project looks at how new Medicaid coverage in California affects foot care, ED visits, and outcomes for adults with diabetes in safety-net populations.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11366730

• Multi-targeted approach to help heal diabetic foot ulcers using electric fields and nitric oxide

  A study to test a combo treatment using electric field stimulation and nitric oxide to boost healing in diabetic foot ulcers.

  NIH research Rowan University · Glassboro, United States · NIH-11361000

• Wound fluid test to predict healing in diabetic foot ulcers

  This project looks for chemical signals in the fluid from diabetic foot ulcers that could tell adults with diabetes whether a wound will heal with standard care or need a different treatment.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11323031

• MTX-001 for healing diabetic foot ulcers in people with diabetes

  A first–in–class biologic therapy called MTX-001 is being tested to help heal diabetic foot ulcers and reduce infection risk in adults with diabetes.

  NIH research Merakris Therapeutics INC · Hillsborough, United States · NIH-11315603

• Modified mRNA bandage for diabetic foot ulcers

  A new topical wound dressing that releases modified mRNA aims to help people with diabetic foot ulcers heal faster and avoid complications.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11311354

• Why ulcers form on the toes, heel, and top of the foot in diabetes

  This project will measure how tissues at common non-sole areas of the diabetic foot (toes, heel, and top) respond to pressure and movement to help people with diabetes avoid ulcers.

  NIH research VA Puget Sound Healthcare System · Seattle, United States · NIH-11310873

• Identifying biomarkers in wound fluid for diabetic foot ulcers

  This study is looking at special substances in the fluid from diabetic foot ulcers to see if they can help doctors predict how well the wounds will heal, which could lead to better and more personalized treatments for people with these types of wounds.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11309403

• CARE-D-Foot-Nav: a diabetic foot care navigation program

  This project sees if giving people with diabetic foot ulcers a trained patient navigator to arrange care, resources, and appointments helps wounds heal and prevents amputations.

  NIH research Emory University · Atlanta, United States · NIH-11291789

• Diabetic foot ulcer data and coordination center

  This center brings clinics and labs together to find blood and wound markers that help predict healing and prevent repeat foot ulcers in people with diabetes.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11290368

• UCSF Diabetic Foot Clinic

  This UCSF program works with people who have diabetes and foot ulcers to collect samples and health information to find markers that help predict healing and prevent amputations.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11257714

• Diabetic Foot Ulcer Clinical Unit

  This program aims to bring quick bedside tests (biomarkers) into clinics to help people with diabetes and foot ulcers get faster, clearer care.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11257687

• Diabetic foot clinic network

  This project runs clinics that look for biological signs to help prevent and heal foot ulcers in people with diabetes.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11257268

• Urine microRNA test to predict healing in diabetic foot ulcers

  This project is creating a urine-based test that uses tiny RNA markers to predict whether a diabetic foot ulcer will heal with standard treatment.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11169779

• Investigating gene markers that affect healing in diabetic foot ulcers

  This study is looking at how inflammation affects the healing of foot ulcers in people with diabetes, and it's creating a special test to help doctors understand how well these wounds are healing so they can provide better, personalized care for patients.

  NIH research Drexel University · Philadelphia, United States · NIH-11166816

• Using urinary microRNAs to predict healing in diabetic foot ulcers

  This study is looking at how tiny molecules in your urine might help doctors predict if your diabetic foot ulcer will heal with regular treatment or if you might need something more advanced, making it easier to get the right care when you need it.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11159351

• Understanding Germs in Diabetic Foot Wounds

  This work explores how the community of germs living in diabetic foot ulcers affects their healing for people with diabetes.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11140538

• Home exercise program to help Veterans recover after a recently healed diabetic foot ulcer

  A home-based exercise program designed to help Veterans who recently healed from a diabetic foot ulcer regain strength, mobility, and independence.

  NIH research Baltimore VA Medical Center · Baltimore, United States · NIH-11132619

• Understanding Diabetic Foot Ulcer Healing

  This project aims to find a way to predict how well diabetic foot ulcers will heal by looking at specific markers related to inflammation.

  NIH research Drexel University · Philadelphia, United States · NIH-11121939

• Predicting Diabetic Foot Ulcer Healing with MRI and Blood Tests

  This work looks for new ways, using MRI scans and blood tests, to tell if a diabetic foot ulcer will heal well or not.

  NIH research Emory University · Atlanta, United States · NIH-11115800

• Lifestyle program to prevent diabetic foot ulcer recurrence

  A lifestyle occupational therapy program helps people with healed diabetic foot ulcers build daily habits and keep pressure off their feet to lower the chance the ulcers come back.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11112541

• A smartphone tool for checking diabetic foot ulcers

  This project is creating a new smartphone tool to help people with diabetes and foot ulcers get better care, especially when they can't easily see a wound care expert.

  NIH research Florida International University · Miami, United States · NIH-11098464

• New treatments for healing diabetic foot ulcers

  This study is exploring new treatments for diabetic foot ulcers to help them heal better and faster, using special materials that encourage your body to produce the healing factors it needs, so you can recover more effectively.

  NIH research University of Delaware · Newark, UNITED STATES · NIH-11097243

• Understanding how gut bacteria affect diabetic foot ulcers

  This study is looking at how the bacteria in our bodies might help or hurt the healing of diabetic foot ulcers, and it's for people with diabetes who want to learn more about improving their wound healing.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11096709

• Understanding why diabetic foot and venous leg ulcers heal poorly

  This study is looking at why diabetic foot ulcers and venous leg ulcers don’t heal well, by examining tissue samples to find out how certain genes and the bacteria on our skin might affect healing, with the hope of creating better treatments for these stubborn wounds.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11093569

• Investigating gene markers that affect healing in diabetic foot ulcers

  This study is looking at how inflammation affects the healing of foot ulcers in people with diabetes, and it aims to find specific genes that can help predict how well these wounds will heal, so that doctors can better manage treatment for patients.

  NIH research Drexel University · Philadelphia, United States · NIH-11090049

• Using biomaterials to improve healing of diabetic foot ulcers

  This study is looking at new materials that could help heal diabetic foot ulcers better by improving blood flow and tissue repair, so people with diabetes can have more effective treatments and a lower risk of serious complications.

  NIH research Yale University · New Haven, United States · NIH-11085184

• Using modified mRNA to improve healing of diabetic foot ulcers

  This study is looking at how special bandages that use modified mRNA can help heal diabetic foot ulcers better, making it easier for people with diabetes to recover from these tough wounds.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11077275

• Understanding the causes of foot ulcers in diabetes patients

  This study is looking at how the way your foot works can lead to sores in people with diabetes, and it's for anyone who wants to understand more about preventing and treating these common foot problems.

  NIH research VA Puget Sound Healthcare System · Seattle, United States · NIH-11053200

• Improving care for diabetic foot ulcers through patient navigation

  This study is looking at how a special support program can help people with diabetes heal their foot ulcers better and avoid amputations, especially for those who might not have easy access to care.

  NIH research Emory University · Atlanta, United States · NIH-11049694

• Improving adherence to orthotic treatment for diabetic foot ulcers

  This study is looking at ways to help people with diabetic foot ulcers wear their special shoe inserts more often, by giving some patients extra support and encouragement while others just get regular care, to see if that makes a difference in their healing.

  NIH research Edward Hines Jr VA Hospital · Hines, United States · NIH-11034078

• Understanding and improving healing of diabetic foot ulcers

  This study is looking for ways to better predict how diabetic foot ulcers heal and to help prevent them from coming back, so if you have diabetes and have dealt with these ulcers, your participation could really help improve future treatments!

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11012894

• Improving care for diabetic foot ulcers

  This study is looking for ways to improve care for people with diabetic foot ulcers by finding helpful markers that can guide treatment, and by joining in, you can help shape better options for managing your condition.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11012856

• Investigating diabetic foot ulcers and their treatment

  This study is looking for ways to help people with diabetes catch and manage foot ulcers early, so they can avoid serious health problems, and it invites patients to participate in different parts of the research to improve treatment options.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11012847

• Investigating diabetic foot ulcers and their treatment

  This study is looking at how to better understand and treat diabetic foot ulcers, so if you have one, you can join us to help find out what helps them heal faster and how social factors might play a role in your recovery.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11012833

• Using smart devices to improve healing of diabetic foot ulcers

  This study is testing a new smart device that helps people with diabetic foot ulcers heal better by reminding them to use it correctly, and it’s comparing how well this device works compared to regular treatment methods.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11012795

• New treatment for diabetic foot ulcers using nanoparticles and microRNA

  This study is testing a new treatment to help heal diabetic foot ulcers faster by using a special injection that targets inflammation and stress in the body, and it's designed for people with diabetes who are dealing with these painful wounds.

  NIH research Ceria Therapeutics, INC. · Tucson, UNITED STATES · NIH-11011333

• Improving treatment for diabetic foot ulcers with a new hydrogel

  This study is testing a new gel that helps heal diabetic foot ulcers by slowly releasing a special growth factor, making it easier for people with diabetes to recover without needing to change their dressings as often.

  NIH research Gelsana Therapeutics, INC. · Aurora, United States · NIH-11007010

• A system to prevent diabetic foot ulcers and their recurrence

  This study is testing a smart foot garment called SoleSaver that helps people with diabetes keep an eye on their foot health to prevent serious issues like foot ulcers, making it easier for them and their caregivers to take care of their feet.

  NIH research Barron Associates, INC. · Charlottesville, United States · NIH-11005852

Related topics

Quick answers

How many Diabetic Foot clinical trials are recruiting right now?

25, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (15 trials), Sweden (4 trials), United Kingdom (1 trial), Italy (1 trial), China (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 3, Early Phase 1: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →