Improving the function of stem cells in diabetic patients with leg problems
Molecular Repair of Diabetic Mesenchymal Stem Cells (dMSC) for Peripheral Arterial Disease
This study is looking at ways to help improve the healing power of special cells in people with diabetes who have trouble with blood flow in their legs, so they can walk better and get back to their daily activities.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Decatur, UNITED STATES) |
| Project ID | NIH-11052120 on NIH RePORTER |
What this research studies
This research investigates how to enhance the healing capabilities of diabetic mesenchymal stem cells in patients suffering from peripheral arterial disease (PAD). The approach focuses on understanding the genetic and cellular mechanisms that affect these stem cells and their ability to regenerate damaged muscle and improve blood flow. By exploring the role of immune cells in muscle repair, the research aims to develop cell therapies that can restore function and mobility in affected individuals. The ultimate goal is to help diabetic patients regain their ability to walk and perform daily activities more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are diabetic patients, particularly veterans, who are experiencing peripheral arterial disease and related mobility issues.
Not a fit: Patients who do not have diabetes or peripheral arterial disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve mobility and quality of life for diabetic patients with peripheral arterial disease.
How similar studies have performed: Previous research has shown promise in using stem cell therapies for similar conditions, indicating potential for success in this innovative approach.
Where this research is happening
Decatur, UNITED STATES
- Veterans Health Administration — Decatur, United States (Active)
Researchers
- Principal investigator: Brewster, Luke Packard — Veterans Health Administration
- Study coordinator: Brewster, Luke Packard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.