Condition
Skin Cancer clinical trials and research
As of November 12, 2026, Find a Trial lists 47 Skin Cancer clinical trials that are recruiting, at sites in 18 countries (most in United States (24), Sweden (5), Israel (4)). By phase: Early Phase 1 (3), Phase 1/2 (3), Phase 2 (3), Phase 4 (2). The most active sponsors are Alpha Tau Medical LTD. (5), Dana-Farber Cancer Institute (3), HJN Sverige AB/Neko Health (2). There are also 53 NIH-funded research projects on Skin Cancer, with $46.5 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 47Clinical trials
- 53NIH research projects
- 18Countries
Newest Skin Cancer clinical trials
All recruiting trials (47)
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Mobile sun protection support to help young adults stay safe in the sun
This project tests a mobile health program to see if reminders, education, planning tools, and real-time sun exposure information can help young adults protect their skin from excessive sun exposure.
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Psycho-physiological profiling of people with low versus high heat resilience
This project will test whether controlled heat and UV exposures plus physiological and psychological measurements can identify healthy adults who are more or less resilient to heat.
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Cosibelimab for tough CSCC in kidney transplant recipients or blood cancers
This trial tests cosibelimab in people with advanced cutaneous squamous cell carcinoma who have a kidney transplant or certain blood cancers to see if it is safe and helpful for them.
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First-line immunotherapy and PD-L1 testing for metastatic melanoma in Slovenia
This study will see if first-line immunotherapy (pembrolizumab, nivolumab, or ipilimumab plus nivolumab) works for adults in Slovenia with metastatic melanoma and whether PD-L1 measurements predict who responds.
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Optical and multi-modal analysis to help diagnose skin cancer
This project tests whether combining optical spectroscopy and imaging data from skin samples can help diagnose skin cancer in people with skin concerns.
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Early skin tumor detection with telemedicine in primary care
This project will test whether a telemedicine tool used by general practitioners can help detect suspicious skin lesions earlier in people with fair skin in the Czech Republic.
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Personalized discharge letters for low-risk skin cancer patients
Researchers are testing if tailored discharge letters, with or without visual aids, help low-risk skin cancer patients understand their care and follow-up better after a dermatology visit.
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Predicting Immunotherapy Response from Live Tumor Biopsies
This project will try to see if analyzing live tumor biopsy samples kept in their 3D environment can predict whether people with advanced solid tumors will respond to immunotherapy.
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Lifileucel (TIL) plus chemotherapy and IL-2 for advanced cutaneous squamous cell and Merkel cell carcinoma
This trial will try lifileucel (tumor-infiltrating lymphocytes) combined with lymphodepleting chemotherapy and interleukin-2 in adults with unresectable or metastatic cutaneous squamous cell carcinoma or Merkel cell carcinoma who have previously received immunotherapy.
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Topical 5% Niacinamide for Skin Cancer Prevention in Organ Transplant Recipients
This trial tests whether applying a 5% niacinamide cream daily, in addition to sunscreen, can reduce actinic keratoses and new skin cancers in adults who have had an organ transplant.
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Skin cancer self-detection education: does framing affect outcomes?
This trial tests a skin cancer education program to see if gain- or loss-framed messages help people with skin of color detect skin changes and adopt sun-protective behaviors.
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Integrating personalized skin cancer risk feedback into community health centers
This project tests whether giving adult patients personalized skin cancer risk information based on genetics and recent sun behaviors increases use of sun-protection and prevention activities at Tampa Family Health Centers.
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Meloxicam for pain after Mohs surgery
This trial will try two doses of meloxicam plus acetaminophen versus acetaminophen with alternating ibuprofen to see which controls pain best for adults having Mohs skin cancer surgery.
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Florida ASCENT Program
This project will test whether combining the MyCarePulse EHR platform with ASCENT patient navigators helps adults with recent cancer diagnoses in Florida improve food security, diet quality, and confidence in healthy eating compared with standard care.
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Lower leg skin grafts after tumour removal: does negative pressure dressings help or not?
This trial tests whether negative pressure wound therapy over split-thickness skin grafts on the lower leg reduces infection compared with traditional dressings in adults after skin tumour removal.
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Fractional laser plus tirbanibulin ointment for basal and squamous cell skin cancers
This trial will try combining fractional laser treatment with tirbanibulin ointment to see if it can treat biopsy-confirmed basal cell and squamous cell skin cancers and reduce the need for surgery.
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Evaluating full-body imaging technology for skin disease detection
This study is testing a new full-body imaging technology to see if it can help doctors better detect and monitor skin diseases like skin cancer and eczema.
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Non-invasive imaging to measure skin composition and structure
This study is testing a new non-invasive imaging technology to see if it can accurately measure different components and structures of skin in people visiting their primary care doctor, especially those at higher risk for heart issues or diabetes.
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AI decision support for detecting skin cancer in primary care
This study will test whether an AI tool called Dermalyser helps primary care clinicians tell skin cancers from harmless skin lesions when patients come in with suspicious spots.
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Early‑phase KESONOTIDE™ treatment for solid tumors
This trial tests an oral drug called KESONOTIDE™ (a vimentin inhibitor) to see if it is safe and tolerable in adults with advanced or metastatic solid tumors like prostate, breast, lung, ovarian cancer, or glioblastoma.
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High-resolution imaging to check if tumors are completely removed during surgery
This study is testing if high-resolution imaging during surgery can help make sure all tumors are removed in patients with different types of cancer, like breast, prostate, and thyroid, to improve their treatment outcomes.
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Using brodalumab to treat immune-related side effects from cancer therapy
This study is testing if brodalumab can help cancer patients who are having immune-related side effects from their immunotherapy treatment feel better.
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Injecting flu vaccine into skin cancer tumors before surgery
This study is testing whether injecting the flu vaccine into skin cancer tumors before surgery can help boost the body's immune response against the cancer in people with cutaneous squamous cell carcinoma.
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Alpha DaRT treatment for skin squamous cell cancer in immunocompromised patients
This study tests whether placing Alpha DaRT seeds directly into a skin squamous cell carcinoma can shrink tumors and improve outcomes in people with compromised immune systems.
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Mechanisms for Laser-Induced Rejuvenation in Skin Cancer Risk Reduction
This study tests whether cells called fibroblasts that appear after Fractionated Laser Resurfacing can be traced to their origin in people planning abdominoplasty.
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Improving sun protection for rural youth to prevent skin cancer
This study is testing a new way to help kids in rural areas of Utah and West Virginia protect themselves from the sun to prevent skin cancer.
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Using Raman Spectroscopy to assess skin cancer tumors
This study is testing a new imaging technique to see if it can help doctors better understand the size and spread of skin cancer tumors in patients with basal cell and squamous cell carcinoma.
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Oral Alintegimod with Ipilimumab followed by Nivolumab for advanced cancer
This study is testing if a new oral medication called Alintegimod, combined with two other cancer treatments, can help people with advanced solid tumors feel better and live longer.
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High-intensity exercise and high-fiber diet for melanoma patients
This study is testing whether high-intensity exercise and a high-fiber diet can help improve health for melanoma patients receiving immunotherapy.
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Testing ONM-501 alone and with Cemiplimab for advanced solid tumors and lymphomas
This study is testing a new treatment called ONM-501, both alone and with another drug called cemiplimab, to see if it can help people with advanced solid tumors and lymphomas who have run out of other treatment options.
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Combining cryoablation with immunotherapy for advanced melanoma
This study is testing if freezing tumors along with two immunotherapy drugs can help people with advanced melanoma that hasn't improved with other treatments.
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Supplemental vitamin A and nicotinamide for kidney transplant recipients at high risk of skin cancer
This pilot will test whether taking oral nicotinamide and vitamin A is safe and doable for kidney transplant recipients who have had recent skin cancers.
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Evaluating oral hedgehog inhibitors for treating basal cell carcinoma in the Netherlands
This study is testing if two oral medications, vismodegib and sonidegib, can help people with advanced basal cell carcinoma or Gorlin syndrome feel better and improve their condition.
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Investigating HPV and skin cancer risks in organ transplant recipients
This study is trying to see if organ transplant recipients have a higher risk of HPV infections and skin cancer compared to people with normal immune systems.
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High-resolution imaging for skin tumors using advanced optical technology
This study is testing a new imaging system to see if it can help doctors better diagnose skin tumors without needing to do painful biopsies.
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Combination treatment for advanced head and neck cancer using radiation and immunotherapy
This study is testing a new treatment for advanced head and neck cancer that combines a special type of radiation with an immunotherapy drug to see if it helps patients with hard-to-treat tumors.
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Using teledermoscopy and AI to improve skin cancer diagnosis
This study is testing if using teledermoscopy and artificial intelligence can improve how doctors diagnose skin cancer and reduce the chances of missing any cases.
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Registry for patients treated with electroporation for cancer
This study is collecting information from cancer patients who have received a new treatment using electroporation with chemotherapy or calcium to see how well it works and what side effects it may cause.
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Treatment of skin and soft tissue cancers using alpha radiation emitters
This study is testing a new treatment that uses tiny radioactive seeds to shrink skin and soft tissue cancers while keeping healthy tissue safe.
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Using stereotactic body radiotherapy for patients with rare oligometastatic cancers
This study is testing if adding a special type of targeted radiation therapy to standard treatment can help people with rare cancers that have spread to a few places live longer and feel better.
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Using blood tests to assess early treatment response in cancer patients
This study is testing if blood tests that look for cancer DNA can help doctors see how well treatment is working for patients with different types of solid tumors.
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Effects of Atezolizumab on Cancer Patients with Sensitive Tumor DNA or RNA
This study is testing if atezolizumab can help cancer patients with certain tumor types that show they might respond well to the treatment.
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Examining skin responses to UV light in day and night shift workers
This study tests how the skin of night shift workers reacts to UV light compared to day shift workers to see if their different schedules affect skin health and cancer risk.
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Treatment of malignant skin tumors using alpha radiation emitters
This study is testing a new treatment that uses special radiation to shrink malignant skin tumors in people who have confirmed skin cancer.
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Treatment of skin and soft tissue cancers using alpha radiation emitters
This study is testing a new treatment that uses tiny radioactive seeds placed directly into skin and soft tissue cancers to see if it can shrink tumors while keeping healthy tissue safe.
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Fractional Laser or Chemical Peel in Older Skin to See IGF-1 Changes
This study tests whether fractional lasers or chemical peels can increase IGF-1 in skin for people over 55 with sun-damaged skin.
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A resource for collecting cancer data and biospecimens
This study is creating a resource to collect health information and samples from cancer patients and healthy individuals to help improve cancer prevention and treatment strategies.
NIH-funded research (newest 40 of 53)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Solar-powered sun protection for outdoor workers
A short project to help outdoor workers prevent skin cancer by using a tailored, story-based video and workplace actions to increase sun protection.
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Skin cancer immunotherapy: better vaccines and biomarkers to help melanoma patients
A Yale-led program tests new drug combinations and biomarker tests to help people with advanced melanoma live longer and better, especially by guiding which treatment works best for them.
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CivaDerm: a new four-day skin cancer radiation bandage
A new four‑day radiation bandage for non-melanoma skin cancer aims to treat facial and other areas without multiple clinic visits or big scars.
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MOSAIC II: MAP Wound Matrix to speed graft readiness after non-melanoma skin cancer surgery
A randomized trial tests a moldable wound scaffold (MAP Wound Matrix) to speed healing and time to graft-ready skin after head and neck cancer surgeries in adults.
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PASS: A family-based approach to sun safety in schools
A parent-focused program delivered through schools aims to help families protect children from sun exposure and reduce skin cancer risk.
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Precision skin cancer risk feedback in community clinics
A multisite study tests giving adults personalized genetic risk information to boost sun protection and skin checks in low-resource primary care settings.
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Sesame: Improving sun protection for melanoma survivors with real-time mobile support
Aimed at adults with a history of melanoma, this project tests a smartphone-based program to help people protect their skin from sun exposure while staying active.
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M-ISIC: Open-Source Platform to Improve Skin Cancer Detection With Images
A multi-institution effort to build and share an open, AI-powered platform that improves how skin cancer is detected from images.
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Topical immunoprevention targets for preventing skin cancer from sun damage
A study at the University of Arizona is exploring immune-based strategies applied to the skin to help prevent skin cancers caused by sun exposure, with a focus on humans and real skin samples.
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Genome-wide study of unusual UV DNA lesions in skin cancer
Researchers are studying rare UV-induced DNA damages that may drive skin cancer, to understand how these lesions cause mutations in humans.
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Personalized skin cancer prevention for at-risk young adults
This program uses personalized UV photos, optional genetic risk information, and action planning to help young adults cut back on tanning and protect their skin.
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Low-energy skin radiation patches for treating non-melanoma skin cancer
A patient-friendly device idea uses a patch to deliver a tiny amount of radiation right at the skin to treat non-melanoma skin cancer in as few visits.
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Skin cancer risk and prediction for people with actinic keratoses
This project will build a prediction tool to estimate future skin cancer risk for people who have actinic keratoses.
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Soft magnetoelastic microneedle patch for quick skin cancer screening
This project will develop a soft, wearable microneedle patch that scans skin stiffness to help find skin cancer earlier in people with suspicious skin lesions.
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Safer medicines to prevent basal and squamous (non‑melanoma) skin cancer
Researchers are developing new, non‑toxic oral rexinoid medicines aimed at preventing basal cell and squamous cell skin cancers, especially for people with weakened immune systems like organ transplant recipients.
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Glycosylation patterns in skin cancer and new therapies
A research project at Emory is exploring how protein sugars change in skin cancer to uncover new treatment targets and therapies.
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Using 5‑FU and vitamin D to boost light-based skin cancer treatment
This project combines low‑intensity light therapy with topical 5‑fluorouracil and vitamin D to help people with basal or squamous cell skin cancers get better results from treatment.
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Mobile sun-safety and activity support for melanoma survivors
This project uses smartphone tools to help melanoma survivors avoid harmful sun exposure while keeping up healthy physical activity.
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Melanoma (skin cancer) research program
This program looks at a blood test and a new drug combination to help people with high-risk or treatment-resistant melanoma get the right immunotherapy with fewer side effects.
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Advancing Treatments for Melanoma and Skin Cancer
This program is looking for new and better ways to treat melanoma and other skin cancers, especially when current treatments aren't enough.
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How immune cells spot early skin cancer
Using a new imaging model, researchers will watch how immune cells detect and control tiny early skin cancers to inform future prevention and treatments.
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Skin cancer prevention messages on social media
This project will create and test social media messages to help teens and young adults avoid risky tanning and protect their skin.
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New treatments and biomarker tests for melanoma
Testing immunotherapy combinations and new biomarker tests to better treat people with advanced or metastatic melanoma.
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Personalized skin cancer risk feedback in community health centers
This project gives adults served by community health centers personalized genetic risk information for skin cancer to help them protect their skin and find problems earlier.
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Global open skin photo platform to improve automated skin cancer detection
This project builds a worldwide, open collection of skin photos and tools to help AI and clinicians better spot skin cancer from images.
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Atlas of early skin changes that lead to cancer
This project will map molecular and immune changes in early skin lesions to help people at risk for melanoma and cutaneous squamous cell carcinoma.
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Investigating how skin cells contribute to the development of skin cancer.
This study is looking at how skin cells get damaged and how that might help a common type of skin cancer, basal cell carcinoma, grow, especially in veterans, by exploring the role of certain cells in the skin that could be influencing this process.
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A new method to help diagnose and treat skin cancer using a mini microscope.
This study is testing a new, gentle device that helps doctors look at skin spots for signs of cancer without needing to do painful biopsies, making it easier and quicker for patients to get the care they need.
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Improving skin cancer prevention for young adults at risk
This study is all about helping young adults, especially college students, learn how to protect their skin from cancer by giving them personalized tips and tools to stay safe in the sun and avoid risky tanning habits.
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Understanding skin cancer risks in patients with actinic keratosis
This study is looking at how having actinic keratosis, which are rough patches on the skin from too much sun, might increase the chances of developing skin cancer, and it aims to help doctors better identify and care for patients at higher risk.
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Creating safe drugs to prevent non-melanoma skin cancer
This study is working on new medications to help prevent skin cancer in people with weakened immune systems, like those who have had organ transplants, by creating safer and more effective options that don’t have the usual side effects of current treatments.
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Improving skin cancer prevention by studying UV-induced mutations
This study is looking at how sunlight can change skin cells in ways that might lead to squamous cell skin cancer, and it's for anyone interested in better ways to prevent skin cancer by finding early signs of damage from the sun.
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Investigating how UV light causes DNA damage linked to skin cancer
This study is looking at how UV light can harm your skin cells and lead to skin cancer, especially melanoma, to find new ways to help prevent and treat it.
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A wearable patch for quick skin cancer screening
This study is testing a soft, wearable patch that uses tiny needles to gently check for skin cancer by measuring how stiff skin spots are, making it easier and quicker for people to get screened without any pain.
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Using secosteroids to treat skin cancer caused by UVB exposure
This study is looking at a new treatment for skin cancer caused by UVB rays, using special compounds that might help slow down cancer growth and heal the skin, so patients can have better options for their care.
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Mapping the early stages of skin cancer development
This study is looking at how skin cancer, especially melanoma and squamous cell carcinoma, develops over time by examining skin samples to see how skin cells change and how the immune system interacts with these changes before cancer starts, helping us understand the journey from early signs to full-blown cancer.
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Integrating personalized skin cancer risk feedback in community health centers
This study is looking to help people understand their personal risk for skin cancer based on their genes, so they can make better choices about sun safety and skin checks, especially in community health centers.
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New treatments for melanoma and skin cancer
This study is looking for new and better ways to treat melanoma and skin cancer for patients who haven't had success with current treatments, including trying out a special device that delivers chemotherapy through tiny needles.
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Understanding how immune cells interact with early skin cancer development
This study is looking at how immune cells interact with skin cancer cells in real-time using special mice, which could help us find new ways to catch and treat skin cancer early on.
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Improving melanoma treatment through better patient selection and combination therapies
This study is looking for ways to improve melanoma treatment by finding blood tests that can help doctors decide if patients should get one type of immunotherapy or a combination of treatments, aiming to minimize side effects and also testing a new therapy for those who don’t respond to the usual treatments.
Related topics
Quick answers
How many Skin Cancer clinical trials are recruiting right now?
47, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 18 countries. The most sites are in United States (24 trials), Sweden (5 trials), Israel (4 trials), Belgium (3 trials), France (3 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Early Phase 1: 3, Phase 1/2: 3, Phase 2: 3, Phase 4: 2. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.