New treatments for Peripheral Arterial Disease related to diabetes
New therapeutic strategies for Peripheral Arterial Disease
This study is looking at new ways to help people with Peripheral Arterial Disease (PAD) and diabetes by exploring how exercise affects muscle health, especially for those who can't exercise because of pain, to find better treatments that improve blood flow and muscle function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10892850 on NIH RePORTER |
What this research studies
This research investigates innovative therapeutic strategies for Peripheral Arterial Disease (PAD), particularly in patients with diabetes. It focuses on understanding how exercise influences metabolic and vascular changes in the muscles, which could lead to new treatment options for those unable to exercise due to pain or complications. By studying a specific molecular target, the estrogen-related receptor alpha (ERRα), the research aims to uncover mechanisms that could enhance blood flow and muscle function. The findings may help develop effective pharmacological treatments that address the unmet needs of PAD patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with Peripheral Arterial Disease, particularly those who also have diabetes and experience limitations in physical activity due to pain.
Not a fit: Patients with Peripheral Arterial Disease who do not have diabetes or those who are not experiencing significant limitations in their physical activity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve mobility and quality of life for patients suffering from Peripheral Arterial Disease.
How similar studies have performed: Previous research has shown promise in using exercise as a therapeutic strategy for PAD, but this specific approach targeting ERRα is novel.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Narkar, Vihang a — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Narkar, Vihang a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.