New treatments for Peripheral Arterial Disease related to diabetes
Official title: New therapeutic strategies for Peripheral Arterial Disease
Funded at University of Texas Hlth Sci Ctr Houston · NIH-10892850 · Data updated 2026-11-12
This study is looking at new ways to help people with Peripheral Arterial Disease (PAD) and diabetes by exploring how exercise affects muscle health, especially for those who can't exercise because of pain, to find better treatments that improve blood flow and muscle function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | August 1, 2021 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $435,702 |
| NIH project number | 5R01HL152108-04 |
| Project ID | NIH-10892850 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with Peripheral Arterial Disease, particularly those who also have diabetes and experience limitations in physical activity due to pain.
✕Less likely to help
Patients with Peripheral Arterial Disease who do not have diabetes or those who are not experiencing significant limitations in their physical activity may not benefit from this research.
What this research studies
This research investigates innovative therapeutic strategies for Peripheral Arterial Disease (PAD), particularly in patients with diabetes. It focuses on understanding how exercise influences metabolic and vascular changes in the muscles, which could lead to new treatment options for those unable to exercise due to pain or complications. By studying a specific molecular target, the estrogen-related receptor alpha (ERRα), the research aims to uncover mechanisms that could enhance blood flow and muscle function. The findings may help develop effective pharmacological treatments that address the unmet needs of PAD patients.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve mobility and quality of life for patients suffering from Peripheral Arterial Disease.
How similar studies have gone: Previous research has shown promise in using exercise as a therapeutic strategy for PAD, but this specific approach targeting ERRα is novel.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Narkar, Vihang a — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Narkar, Vihang a
Related research
Other NIH-funded projects on the same topics.
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Contrast-free ultrasound to measure tiny blood flow in legs to help PAD
A noninvasive ultrasound approach uses new metrics to quantify microvascular blood flow in the lower leg to aid in diagnosing and managing peripheral arterial disease.
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Understanding Spp1+ Macrophages and Muscle Healing in Peripheral Artery Disease
This grant supports a physician-scientist in Duke's vascular surgery program to study how a specific macrophage type called Spp1+ macrophages affect muscle healing in people with peripheral artery disease.
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Reprogrammed Monocytes for improved blood vessel growth in leg PAD
A study to see if reprogramming a patient’s own monocytes can boost new blood vessel growth and improve limb health in people with peripheral artery disease.
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This grant explores a new way to help people with severe leg artery disease by making certain immune cells grow more blood vessels to improve blood flow.
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Carnosine and improved leg function in peripheral artery disease
This grant tests whether taking carnosine can improve leg function for people with peripheral artery disease.
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Understanding how CKD worsens leg artery disease at the cellular level
This grant explores why people with chronic kidney disease have faster, more severe peripheral artery disease and how specific cellular pathways contribute to worse blood flow and limb risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.