Mapping energy metabolism in patients with peripheral arterial disease using MRI.
Official title: MRI based phosphocreatine mapping method to assess patients with peripheral arterial disease.
Funded at Hugo W. Moser Res Inst Kennedy Krieger · NIH-10677775 · Data updated 2026-11-12
This study is exploring a new way to check how well your muscles are working if you have peripheral arterial disease (PAD) by using a special type of MRI that looks at energy levels in your muscles, which could help doctors understand your condition better and find the right treatments for you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hugo W. Moser Res Inst Kennedy Krieger NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 1, 2020 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $409,328 |
| NIH project number | 5R01HL149742-04 |
| Project ID | NIH-10677775 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with peripheral arterial disease who experience functional limitations and symptoms related to muscle ischemia.
✕Less likely to help
Patients without peripheral arterial disease or those with non-ischemic muscle conditions may not benefit from this research.
What this research studies
This research investigates a new method to assess patients with peripheral arterial disease (PAD) by mapping phosphocreatine levels in skeletal muscle using advanced MRI techniques. Current assessments often fail to correlate with the functional limitations experienced by PAD patients, leading to a need for more specific tests. The study aims to utilize chemical exchange saturation transfer (CEST) MRI to noninvasively measure and visualize energy metabolism in muscle tissue, potentially providing insights into the severity of ischemia and mitochondrial function. This approach could help identify patients who may benefit from targeted therapies and improve their quality of life.
Why it matters
Potential benefit: If successful, this research could lead to more accurate assessments of muscle function in PAD patients, guiding better treatment strategies.
How similar studies have gone: While the use of CEST MRI is a novel approach, previous studies have shown promise in using advanced imaging techniques to assess metabolic function in various conditions.
Where this research is happening
-
Hugo W. Moser Res Inst Kennedy Krieger
Baltimore, United States Active
Researchers
- Principal investigator: Xu, Jiadi — Hugo W. Moser Res Inst Kennedy Krieger
- Study coordinator: Xu, Jiadi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.