Carnosine and improved leg function in peripheral artery disease
Official title: Role of carnosine in peripheral arterial disease
Funded at University of Louisville · NIH-11364175 · Data updated 2026-11-12
This grant tests whether taking carnosine can improve leg function for people with peripheral artery disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project start | August 15, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $632,838 |
| NIH project number | 5R01HL163419-03 |
| Project ID | NIH-11364175 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with diagnosed peripheral arterial disease who are candidates for non-surgical management and can participate in functional testing.
✕Less likely to help
Patients without PAD or those unable to take supplements may not benefit and could experience no change.
What this research studies
People living with PAD often have poor muscle metabolism in their legs, leading to pain and reduced walking ability. The study will give carnosine supplements to PAD patients and measure changes in lower-extremity function. It also includes lab studies to understand how carnosine helps muscles, buffers pH, and may support angiogenesis and protection from harmful molecules. The goal is to see if a simple supplement could become a new, practical option to improve limb health and exercise tolerance in PAD.
Why it matters
Potential benefit: If successful, patients with PAD could gain improved leg function and quality of life through a relatively easy-to-take supplement.
How similar studies have gone: Preliminary data in related muscle-ischemia contexts suggest potential benefits of carnosine for buffering and metabolism, but this specific approach in PAD is being tested.
Where this research is happening
-
University of Louisville
Louisville, United States Active
Researchers
- Principal investigator: Baba, Shahid P — University of Louisville
- Study coordinator: Baba, Shahid P
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.