Comparing high-intensity and low-to-moderate exercise for patients with peripheral artery disease
Short-duration Aerobic High-intensity Intervals Versus Low-to-moderate-intensity Exercise Training in Symptomatic Patients With Peripheral Artery Disease: A Randomized Controlled Trial
This study is testing whether high-intensity workouts or gentler exercises help people with peripheral artery disease walk better and feel healthier.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire Vaudois Academic / other |
| Locations | 1 site (Lausanne, Canton of Vaud) |
| Trial ID | NCT05612945 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effects of high-intensity interval training (HIIT) versus low-to-moderate intensity training on patients with symptomatic peripheral artery disease (PAD). The study aims to determine the optimal exercise intensity for improving walking capacity and quality of life in these patients. Participants will be assigned to either the HIIT group or the low-to-moderate intensity group, with their progress monitored through supervised exercise training. The trial seeks to clarify the role of exercise intensity in rehabilitation for PAD, which has been inadequately addressed in previous research.
Who should consider this trial
Good fit: Ideal candidates for this study are adult patients with symptomatic PAD who can walk on a treadmill and meet specific clinical criteria.
Not a fit: Patients who are unable to walk at the required speed or have significant comorbidities that affect their ability to exercise may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective exercise prescriptions for improving the health and quality of life of patients with peripheral artery disease.
How similar studies have performed: Previous studies have shown positive outcomes with supervised exercise training in PAD, but this specific comparison of exercise intensities is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients with symptomatic PAD (Fontaine stage IIa/b); * ABI ≤ 0.9 or drop by 20% following exercise treadmill test 1; * TBI ≤ 0.6 if incompressible arteries (diabetes and renal insufficiency); * Signed written informed consent form. Exclusion Criteria: * Age \< 18; * Unable to walk at 3.2 km/h on a treadmill (slope 0%) at least 300 m; * Previous participate in SET programs ≤ 1 year; * Prior leg/foot amputation; * Contraindication to exercise * Neurological and neuromuscular disorders and other comorbidities (orthopedic, rheumatologic) leading to gait abnormalities. * Known Pregnancy * Incapacity of discernment
Where this trial is running
Lausanne, Canton of Vaud
- Chuv — Lausanne, Canton of Vaud, Switzerland (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.