Comparing high-intensity and low-to-moderate exercise for patients with peripheral artery disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of high-intensity interval training (HIIT) versus low-to-moderate intensity training on patients with symptomatic peripheral artery disease (PAD). The study aims to determine the optimal exercise intensity for improving walking capacity and quality of life in these patients. Participants will be assigned to either the HIIT group or the low-to-moderate intensity group, with their progress monitored through supervised exercise training. The trial seeks to clarify the role of exercise intensity in rehabilitation for PAD, which has been inadequately addressed in previous research.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients with symptomatic PAD (Fontaine stage IIa/b);
* ABI ≤ 0.9 or drop by 20% following exercise treadmill test 1;
* TBI ≤ 0.6 if incompressible arteries (diabetes and renal insufficiency);
* Signed written informed consent form.

Exclusion Criteria:

* Age \< 18;
* Unable to walk at 3.2 km/h on a treadmill (slope 0%) at least 300 m;
* Previous participate in SET programs ≤ 1 year;
* Prior leg/foot amputation;
* Contraindication to exercise
* Neurological and neuromuscular disorders and other comorbidities (orthopedic, rheumatologic) leading to gait abnormalities.
* Known Pregnancy
* Incapacity of discernment

Where it's running

• Chuv
  Lausanne, Canton of Vaud, Switzerland Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.