Clinical trial Recruiting at 1 site Observational Ages 6 and up

Research on health inequality and genetic disparity in cardiovascular diseases

Official title: EMPOWER-1: A Multi-site Clinical Cohort Study to Reduce Health Inequality: Identifying Ethnic Disparities in Treatment Failures for Medicines Prescribed to Treat Diseases That Cause Significant Mortality and Morbidity in the UK Population

Run by Future Genetics Limited · NCT03987633 · Data updated 2026-11-12

This study is trying to understand how health differences and genetics affect heart diseases in people from various ethnic backgrounds in the UK to help improve treatments for everyone.

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Quick facts

Study typeObservational
Ages6 Years and up
SexAll
Enrollment200000 (estimated)
SponsorFuture Genetics Limited
Academic / other
Locations1 site (Wolverhampton, West Midlands)
StatusRecruiting
StartedFebruary 1, 2020
Main results expectedFebruary 1, 2028
Study endsFebruary 1, 2030
Registry record updatedMarch 10, 2025
Trial IDNCT03987633 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include patients diagnosed with atrial fibrillation, coronary heart disease, heart failure, hypertension, or other cardiovascular diseases, particularly from the specified ethnic groups.

Probably not a fit

Patients who are not registered with the NHS or lack the capacity to provide consent may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to address health inequality and genetic disparity in the UK by recruiting up to 200,000 patients from diverse ethnic backgrounds, specifically White, African-Caribbean, and South Asian populations. It will analyze biological samples, medical records, and questionnaires to identify treatment failures in various cardiovascular diseases. The study seeks to provide real-world evidence on disease prevalence and inform clinical practices to improve health outcomes for underrepresented populations. By pooling data from multiple NHS sites, the research will ensure a meaningful representation of different ethnicities.

Why it matters

Potential benefit: If successful, this study could lead to improved treatment strategies and health outcomes for diverse patient populations suffering from cardiovascular diseases.

How similar studies have gone: While the focus on health inequality and genetic disparity is increasingly recognized, this specific approach of large-scale, multi-ethnic cohort analysis is relatively novel and has not been extensively tested in prior studies.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Patients or their relative/family member is diagnosed with the illness being investigated by this study.
2. All NHS patients that are associated with a participating study site, but do not fall under the first bullet point above, may participate with a view that they may potentially contribute to a case control population in the research study.
3. Subjects agree to:

   1. Gift biological samples, i.e. saliva. Where practical, blood or other biological samples may be voluntarily provided by the patient.
   2. Provide Consent for access to medical records.
   3. Complete disease specific, quality of life, and study associated questionnaires.

Exclusion Criteria:

1. Patient does not provide a valid consent for study participation.
2. Patient is not registered with the NHS for care.
3. Patient lacking capacity, who does not have an illness that is being specifically investigated by this clinical research study.
4. Person lacks capacity and where the personal consultee has not advised that the Person may enrol, in accordance with the Mental Health Act 2005.

Where it's running

  • Future Genetics, The Science Centre, Wolverhampton Science Park
    Wolverhampton, West Midlands, United Kingdom
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.