Reprogrammed immune cells help improve blood vessel growth in patients with severe leg artery disease.
Reprogrammed Monocytes Improve Neovascularization in Peripheral Arterial Disease
This study is looking at how changing certain immune cells in people with critical limb ischemia can help grow new blood vessels and improve blood flow in their legs, especially for those who can't have regular surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11019879 on NIH RePORTER |
What this research studies
This research focuses on patients with critical limb ischemia (CLI), a severe form of peripheral artery disease that can lead to pain, gangrene, and amputation. The study investigates how reprogramming certain immune cells, called monocytes, can enhance the formation of new blood vessels in the affected limbs. By using a technique called ischemia training, researchers aim to improve blood flow and healing in patients who are not candidates for traditional surgical interventions. The approach involves understanding the role of specific enzymes and cellular mechanisms in promoting neovascularization.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from critical limb ischemia who are not eligible for limb revascularization procedures.
Not a fit: Patients with mild peripheral artery disease or those who have already undergone successful revascularization may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new therapeutic option to improve blood flow and reduce the need for amputations in patients with severe leg artery disease.
How similar studies have performed: Previous research has shown promising results in using immune cell reprogramming for enhancing blood vessel growth, indicating potential success for this novel approach.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Lassance-Soares, Roberta Marques — University of Miami School of Medicine
- Study coordinator: Lassance-Soares, Roberta Marques
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.