Improving blood flow in limbs using ultrasound

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the use of contrast-enhanced ultrasound (CEU) to enhance limb tissue perfusion in patients with peripheral arterial disease (PAD). The research builds on previous findings that CEU can significantly increase blood flow, and aims to determine the effectiveness of specific ultrasound settings within FDA-approved limits. Participants will undergo ultrasound imaging to measure the degree of perfusion augmentation, providing insights into potential therapeutic applications for PAD.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 y.o.
* For PAD subjects: known history of unilateral or bilateral PAD diagnosed by reduced ankle-brachial index or angiography and a Rutherford symptom class of 4-6.

Exclusion Criteria:

1. Major medical illness other than PAD affecting the limb (muscle disease, blood diseases that influence flow or rheology, severe heart failure \[NYHA class IV or LVEF \<30%\]).
2. Pregnant or lactating females
3. Hypersensitivity to any ultrasound contrast agent
4. Known atrial septal defect or large right to left shunt.
5. Hemodynamic instability (hypotension with systolic BP \<90 mm Hg, need for vasopressors)
6. Evidence for ongoing myocardial ischemia
7. For normal controls, any known structural non-arrhythmic cardiovascular disease (coronary artery disease, heart failure, moderate or greater valve disease).

Where it's running

• Ohsu
  Portland, Oregon, United States Recruiting

Study contacts

• Study coordinator: Jonathan R Lindner, MD
• Email: lindnerj@ohsu.edu
• Phone: 5034943574

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.