Exercise therapy before and after stenting for leg artery disease
Official title: Prehabilitation and Rehabilitation in PAD: A Randomized Exercise Intervention Trial (PREPARE-IT)
Run by Palo Alto Veterans Institute for Research · NCT06566976 · Data updated 2026-11-12
This study tests whether exercise programs before and after stenting can help people with leg artery disease feel better and recover faster.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Palo Alto Veterans Institute for Research Academic / other |
| Locations | 1 site (Palo Alto, California) |
| Status | Recruiting |
| Started | March 7, 2024 |
| Main results expected | January 31, 2027 |
| Study ends | July 25, 2027 |
| Registry record updated | August 22, 2024 |
| Trial ID | NCT06566976 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults diagnosed with PAD who experience leg pain while walking and are scheduled for a stent procedure.
✕Probably not a fit
Patients who are medically unstable, have had a recent heart attack, or have uncontrolled diabetes may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of prehabilitation and rehabilitation exercise programs for patients with peripheral artery disease (PAD) who are scheduled to undergo stenting. It aims to improve patients' exercise tolerance and lifestyle factors before the procedure, potentially leading to fewer complications and a quicker recovery. Participants will engage in a structured exercise regimen designed to enhance their overall health and ability to perform daily activities. The study will assess the impact of these interventions on pain management and quality of life post-surgery.
Why it matters
Potential benefit: If successful, this approach could significantly improve recovery outcomes and quality of life for patients with peripheral artery disease.
How similar studies have gone: Previous studies have shown that exercise-based rehabilitation can greatly benefit patients with PAD, indicating a promising approach for this intervention.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male or Female adult diagnosed with peripheral artery disease (PAD) * Experiencing leg pain while walking * Scheduled to have a stent for PAD * Able to perform exercise safely * Postmenopausal and not of child bearing capacity Exclusion Criteria: * Medically unstable patients * Recent MI within 3 months * Malignancy * Uncontrolled diabetes mellitus (HBA1C ≥8 mmol/l) * Alcoholism or other recreational drug use
Where it's running
-
VA Palo Alto Health Care System
Palo Alto, California, United States Recruiting
Study contacts
- Study coordinator: Jonathan N Myers, PhD
- Email: drj993@aol.com
- Phone: 650-493-5000
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.