Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Exercise therapy before and after stenting for leg artery disease

Official title: Prehabilitation and Rehabilitation in PAD: A Randomized Exercise Intervention Trial (PREPARE-IT)

Run by Palo Alto Veterans Institute for Research · NCT06566976 · Data updated 2026-11-12

This study tests whether exercise programs before and after stenting can help people with leg artery disease feel better and recover faster.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment300 (estimated)
SponsorPalo Alto Veterans Institute for Research
Academic / other
Locations1 site (Palo Alto, California)
StatusRecruiting
StartedMarch 7, 2024
Main results expectedJanuary 31, 2027
Study endsJuly 25, 2027
Registry record updatedAugust 22, 2024
Trial IDNCT06566976 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include adults diagnosed with PAD who experience leg pain while walking and are scheduled for a stent procedure.

Probably not a fit

Patients who are medically unstable, have had a recent heart attack, or have uncontrolled diabetes may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of prehabilitation and rehabilitation exercise programs for patients with peripheral artery disease (PAD) who are scheduled to undergo stenting. It aims to improve patients' exercise tolerance and lifestyle factors before the procedure, potentially leading to fewer complications and a quicker recovery. Participants will engage in a structured exercise regimen designed to enhance their overall health and ability to perform daily activities. The study will assess the impact of these interventions on pain management and quality of life post-surgery.

Why it matters

Potential benefit: If successful, this approach could significantly improve recovery outcomes and quality of life for patients with peripheral artery disease.

How similar studies have gone: Previous studies have shown that exercise-based rehabilitation can greatly benefit patients with PAD, indicating a promising approach for this intervention.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Male or Female adult diagnosed with peripheral artery disease (PAD)
* Experiencing leg pain while walking
* Scheduled to have a stent for PAD
* Able to perform exercise safely
* Postmenopausal and not of child bearing capacity

Exclusion Criteria:

* Medically unstable patients
* Recent MI within 3 months
* Malignancy
* Uncontrolled diabetes mellitus (HBA1C ≥8 mmol/l)
* Alcoholism or other recreational drug use

Where it's running

  • VA Palo Alto Health Care System
    Palo Alto, California, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.