Exploring the links between oral bacteria, muscle blood flow, and fitness levels

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the relationships between fitness status, oral microbiome bacteria, and blood flow to skeletal muscles. Participants will undergo various assessments, including mouth swabs, saliva samples, maximum effort cycling, blood draws, and ultrasound tests to measure muscle blood flow. The study seeks to understand how fitness levels may influence oral bacteria and the body's ability to deliver blood to muscles, particularly in the context of cardiovascular health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subjects must be able to communicate meaningfully with the investigator and must be legally competent to provide written informed consent.
* Subjects may be of either sex with age 18 years.

Exclusion Criteria:

* Oral antibiotic use within previous four weeks
* Oral disease or poor oral health as determined by the Oral Health Questionnaire
* Using an antibacterial mouthwash or a mouthwash containing chlorhexidine and unwilling to discontinue use
* Tobacco smokers
* Pregnant or lactating females
* Hypersensitivity to any ultrasound contrast agent
* Inability to perform exercise
* Unable to communicate effectively in English to the study team.
* Diagnosis of chronic renal failure (GFR \< 60 ml/min/1.73m)
* Subjects taking nitroglycerine (or inorganic nitrates), PDE-5 inhibitors (ex: Cialis, Viagra), and xanthine oxidase inhibitors (ex: Allopurinol).

Where it's running

• UVA Student Health and Wellness Building
  Charlottesville, Virginia, United States Recruiting

Study contacts

• Principal investigator: Jason D Allen, PhD — University of Virginia
• Study coordinator: Casey C Derella, PhD
• Email: bxg7vn@virginia.edu
• Phone: 6092476377

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.