Condition

Critical Limb Ischemia clinical trials and research

• 16Clinical trials
• 7NIH research projects
• 8Countries

Newest Critical Limb Ischemia clinical trials

All recruiting trials (16)

• Local and systemic macrophage activation in coronary and peripheral artery disease

  This study tests whether macrophage activity inside coronary and peripheral arteries relates to circulating monocyte subtypes in people with stable and acute artery disease.

  Recruiting Maria Cecilia Hospital · Cotignola, Ravenna · NCT07588295

• Assessing temperature changes in legs before and after vascular procedures

  This study is testing if measuring leg temperatures with a thermal camera before and after surgery can help predict how well patients with peripheral arterial disease will do after their procedures.

  Recruiting at 3 sites University Hospitals Cleveland Medical Center · Beachwood, Ohio and 2 other locations · NCT06544135

• Evaluating a new catheter for treating blocked arteries in the legs

  This study is testing a new catheter to see if it can help improve blood flow in patients with blocked leg arteries compared to standard treatment.

  Recruiting at 2 sites Cagent Vascular LLC · New York, New York and 1 other locations · NCT06434194

• Assessing the Systolic Rise Time's ability to predict limb and cardiovascular events in severe peripheral artery disease

  This study is testing if a specific measurement from the foot can help predict serious problems with limbs and heart health in people with severe peripheral artery disease.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT06318767

• Using a bioresorbable scaffold to treat below-the-knee artery blockages in Australia

  This study is testing a new dissolvable device to see if it can help people with blocked leg arteries feel better and improve blood flow.

  Recruiting R3 Vascular Inc. · Randwick, New South Wales · NCT06075940

• Examining microRNAs in patients with Critical Limb Ischemia

  This study is trying to see if certain tiny molecules in muscle tissue can help us understand critical limb ischemia better by comparing patients with this condition to those who have a different blood vessel issue.

  Recruiting IRCCS Policlinico S. Donato · San Donato Milanese, Milan · NCT06066268

• Using Stempeucel® to treat critical limb ischemia in patients with peripheral arterial disease

  This study is testing if a stem cell treatment called Stempeucel® can help Malaysian patients with critical limb ischemia feel better and heal faster.

  Recruiting Phase 4 Cell Biopeutics Resources Sdn Bhd · Kuala Lumpur · NCT05854641

• Using Stempeucel® to treat critical limb ischemia from Buerger's disease

  This study is testing whether a stem cell treatment called Stempeucel® can help Malaysian patients with critical limb ischemia from Buerger's disease feel better and heal over a year.

  Recruiting Phase 4 Cell Biopeutics Resources Sdn Bhd · Kuala Lumpur · NCT05854615

• Minimally invasive treatment for severe leg blood flow issues

  This study is testing a new, less invasive treatment for people with severe leg blood flow problems who can't have regular surgery to see if it helps improve their condition.

  Recruiting at 8 sites LimFlow, Inc. · La Jolla, California and 29 other locations · NCT05313165

• Evaluating Shockwave Intravascular Lithotripsy for Calcified Femoral Arteries

  This study is testing if a new shockwave treatment can help people with blocked femoral arteries due to calcium buildup feel better and improve their health.

  Recruiting Yale University · New Haven, Connecticut and 1 other locations · NCT05145478

• Temsirolimus injected around below-knee arteries to improve angioplasty or atherectomy results

  This trial will test whether injecting low-dose temsirolimus around below-knee arteries at the time of angioplasty or atherectomy reduces amputations and the need for repeat procedures in people with symptomatic peripheral artery disease or critical limb ischemia.

  Recruiting at 2 sites Phase 3 Mercator MedSystems, Inc. · Houma, Louisiana and 1 other locations · NCT04433572

• Cohort of patients with severe leg artery blockage undergoing surgery

  This study looks at how well different surgical treatments work for hospitalized patients with severe leg artery blockage to help improve their chances of keeping their limbs and feeling better.

  Recruiting Fondation Hôpital Saint-Joseph · Paris · NCT04312451

• Using FAZA PET/MRI to assess critical limb ischemia before and after revascularization

  This study is testing a new imaging tool to see how well it can help doctors understand and treat people with critical limb ischemia before and after they have surgery to improve blood flow.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT04054609

• Management of severe limb ischaemia and its outcomes

  This study looks at patients with severe limb ischaemia to see how often they need major amputations within a year and how factors like frailty and heart health affect their outcomes.

  Recruiting University of Leicester · Leicester, Leicestershire · NCT04027244

• Using hyperbaric oxygen therapy after lower limb amputation

  This study is testing if adding hyperbaric oxygen therapy after a leg amputation can help patients heal better and reduce the chances of needing more amputations.

  Recruiting at 2 sites Oslo University Hospital · Oslo and 1 other locations · NCT03594344

• Nutritional support for patients with Critical Limb Ischemia

  This study tests if giving nutritional supplements to patients with Critical Limb Ischemia before and after surgery can help them recover better and feel stronger.

  Recruiting Early Phase 1 Boston Medical Center · Boston, Massachusetts · NCT03529019

NIH-funded research (7)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Ultrasound-activated implants to restore blood flow in severe leg ischemia

  This project develops ultrasound-triggered implants that release blood-vessel–growing proteins to help people with critical limb ischemia regain circulation.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11241145

• New gene therapy to improve blood flow and prevent limb amputation in patients with severe artery blockage

  This study is testing a new gene therapy that aims to help people with critical limb ischemia by encouraging blood vessel growth in their legs, which could help heal wounds and reduce the need for amputations, especially for those who haven't had success with regular treatments.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11175713

• Investigating the role of a specific microRNA in improving blood flow in diabetic patients with critical limb ischemia

  This study is looking at how a tiny molecule called miR-130b can help improve blood flow in the legs of people with diabetes who have serious circulation problems, with the goal of finding new ways to prevent amputations and help patients feel better.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10989897

• Investigating treatment outcomes for patients with critical limb ischemia and end-stage renal disease

  This study is looking at the best treatment options for people with critical limb ischemia who also have severe kidney disease, to help doctors and patients make better choices about care and improve health outcomes.

  NIH research University of Florida · Gainesville, United States · NIH-10897869

• New gene therapy to save limbs from severe blood flow issues

  This study is testing a new gene therapy to help people with critical limb ischemia, a serious condition that causes poor blood flow to the legs, by encouraging the growth of new blood vessels to improve healing and reduce pain.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-10843923

• Understanding how diabetes affects blood vessel fat metabolism to reduce surgical complications

  This study is looking at how diabetes affects blood flow and can lead to serious problems like amputations, and it will test if a medication called Fenofibrate, which helps lower fat levels in the blood, can help reduce the risk of these complications for people with diabetes.

  NIH research Washington University · Saint Louis, United States · NIH-10810711

• Exploring pain management and psychological factors in critical limb ischemia

  This study is looking at how different ways to manage pain and mental health support can help people with critical limb ischemia (CLI) feel better and improve their quality of life.

  NIH research Yale University · New Haven, United States · NIH-10599675

Related topics

Quick answers

How many Critical Limb Ischemia clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (6 trials), France (2 trials), Malaysia (2 trials), Italy (2 trials), Australia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Phase 3: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →