Condition

Chronic Limb-Threatening Ischemia clinical trials and research

• 20Clinical trials
• 7NIH research projects
• 10Countries

Newest Chronic Limb-Threatening Ischemia clinical trials

All recruiting trials (20)

• Predictors of Major Adverse Limb Events After Iliac Artery Stenting

  This study tests what factors predict serious limb-related problems after iliac artery stenting in adults with peripheral artery disease.

  Recruiting I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio · Milan, Mi · NCT07672249

• Colchicine for people with severe limb-threatening leg artery disease

  A low-dose colchicine pill is being tested to see if it can help people with chronic limb-threatening ischemia avoid worsening of their leg condition and improve outcomes.

  Recruiting at 2 sites Phase 3 Shin Kong Wu Ho-Su Memorial Hospital · Taipei, Taipei and 4 other locations · NCT07536373

• Imaging plaque activity across the body in people with symptomatic peripheral arterial disease

  This project will use whole-body PET-CT and CT angiography with several tracers to see if imaging can detect inflammation, microcalcification, and clot activity in people with symptomatic peripheral arterial disease.

  Recruiting University of Edinburgh · Edinburgh, Midlothian · NCT07472049

• Vessel recoil after below-the-knee revascularization in high-risk CLTI patients

  This study tests how much vessels recoil after a final endovascular treatment in adults with chronic limb-threatening ischemia affecting below-the-knee arteries.

  Recruiting Medical University of Graz · Graz · NCT07465627

• APAC for blocked leg arteries and chronic limb‑threatening ischemia

  This trial will test whether APAC can prevent blood clots and is safe for people with blocked leg arteries (PAOD) or severe poor blood flow that threatens the limb (CLTI).

  Recruiting at 3 sites Phase 2 Aplagon Oy · Helsinki and 2 other locations · NCT07352800

• Exercises to Improve Lower-Leg Blood Flow and Wound Healing

  This program will test whether a tailored exercise system can improve lower-leg circulation and help chronic wounds in older adults with poor peripheral blood flow.

  Recruiting National Health Research Institutes, Taiwan · Taipei · NCT07330635

• Esprit BTK everolimus-eluting resorbable scaffold in infrapopliteal artery disease for CLTI

  This study tests whether the Esprit BTK Everolimus Eluting Resorbable Scaffold works in real-world patients with chronic limb-threatening ischemia and heavily calcified infrapopliteal arteries.

  Recruiting Cardiovascular and Interventional Radiological Society of Europe · Hull · NCT07270575

• Esprit BTK everolimus-eluting resorbable scaffold in infrapopliteal artery disease for CLTI

  This study tests whether the Esprit BTK Everolimus Eluting Resorbable Scaffold works in real-world patients with chronic limb-threatening ischemia and heavily calcified infrapopliteal arteries.

  Recruiting Cardiovascular and Interventional Radiological Society of Europe · Hull · NCT07270575

• Orbital Atherectomy to Prep Calcified Leg Arteries in CLTI Patients

  This Europe-wide study tests how well orbital atherectomy helps patients with chronic limb-threatening ischemia when opening heavily calcified leg arteries.

  Recruiting Cardiovascular and Interventional Radiological Society of Europe · Hull · NCT07270562

• Orbital Atherectomy to Prep Calcified Leg Arteries in CLTI Patients

  This Europe-wide study tests how well orbital atherectomy helps patients with chronic limb-threatening ischemia when opening heavily calcified leg arteries.

  Recruiting Cardiovascular and Interventional Radiological Society of Europe · Hull · NCT07270562

• Opening one versus multiple below-knee arteries to save legs in severe chronic limb-threatening ischemia

  This trial will test whether opening a single below‑knee artery or opening multiple below‑knee arteries with balloon angioplasty better preserves the leg in people aged 40+ with severe chronic limb‑threatening ischemia (Rutherford 4–5).

  Recruiting Sohag University · Sohag, Sohag Governorate · NCT07068789

• IVUS-guided revascularization for leg arteries in CLTI

  This study tests whether using intravascular ultrasound (IVUS) during leg artery revascularization helps reduce major limb events and significant re-narrowing in adults with chronic limb-threatening ischemia.

  Recruiting at 5 sites Hamilton Health Sciences Corporation · Montreal, Quebec and 4 other locations · NCT06979284

• Pressure-wire guidance for below-the-knee artery angioplasty

  This will test if using a pressure wire to guide below-the-knee balloon angioplasty helps people with severe limb-threatening ischemia of the anterior or posterior tibial arteries.

  Recruiting Yonsei University · Seoul · NCT06879561

• Using shockwave balloons to treat severe calcification in leg arteries

  This study is testing whether shockwave balloon therapy can help people with peripheral artery disease who have severe calcification in their leg arteries feel better and improve blood flow.

  Recruiting Liyuan Hospital of Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT06713850

• Evaluating flow measurement and ultrasound imaging in vein bypass surgery for limb ischemia

  This study is testing if using special tools to measure blood flow and take pictures of veins can help improve the results of vein bypass surgery for people with serious circulation problems in their legs.

  Recruiting Medistim ASA · San Francisco, California · NCT06264843

• Using mobile health data to improve recovery after bypass surgery for leg ischemia

  This study is testing if using health data from a smartwatch can help older patients recover better and move more easily after bypass surgery for leg problems.

  Recruiting University of Florida · Gainesville, Florida · NCT06263322

• Sirolimus-eluting bioresorbable scaffold for below-the-knee artery blockages

  This trial will try a dissolvable sirolimus-coated scaffold to open below-the-knee arteries in adults with chronic limb-threatening ischemia (Rutherford 4–5).

  Recruiting at 3 sites R3 Vascular Inc. · New York, New York and 2 other locations · NCT06071429

• Drug-coated balloon angioplasty for below the knee arterial lesions

  This study is testing whether a special drug-coated balloon treatment can help people with severe leg circulation problems heal better and avoid complications.

  Recruiting at 10 sites Liyuan Hospital of Tongji Medical College, Huazhong University of Science and Technology · Beijing, Beijing Municipality and 9 other locations · NCT05620095

• Minimally invasive treatment for severe leg blood flow issues

  This study is testing a new, less invasive treatment for people with severe leg blood flow problems who can't have regular surgery to see if it helps improve their condition.

  Recruiting at 8 sites LimFlow, Inc. · La Jolla, California and 29 other locations · NCT05313165

• Imaging blood flow in patients with peripheral artery disease

  This study is testing how imaging blood flow in the legs can help doctors understand and improve treatment for people with peripheral artery disease who are having surgery to restore blood flow.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT03622359

NIH-funded research (7)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Proteomics and precision treatment for severe limb-threatening PAD (CLTI)

  A patient-facing look at using blood protein data to predict outcomes and guide safer, more effective treatment for people with the most severe peripheral artery disease.

  NIH research New York University School of Medicine · New York, United States · NIH-11465702

• Tailored treatment paths for people with severe limb-threatening leg artery disease

  This grant aims to use advanced analytics to create personalized treatment sequences for adults with chronic limb-threatening ischemia to improve survival and limb preservation.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11393306

• Improving Chronic Limb-Threatening Ischemia in the U.S.

  A nationwide study aims to understand why some people with severe leg artery disease progress to limb-threatening conditions and amputation, with an emphasis on Black adults and other communities.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11294860

• Fatty scarring in severe leg ischemia

  Researchers are seeing whether changing a cell signal called Hedgehog can reduce fat and scar tissue in calf muscles and help people with severe poor blood flow to the leg regain better blood flow and muscle function.

  NIH research University of Florida · Gainesville, United States · NIH-11253308

• Using stem cells to improve blood flow in patients with severe leg ischemia

  This study is testing a new way to help veterans with chronic limb threatening ischemia, a serious condition that can lead to losing a limb, by using special cells to improve blood flow and heal damaged blood vessels.

  NIH research Veterans Health Administration · Decatur, UNITED STATES · NIH-11091415

• Investigating how fatty fibrosis affects severe limb ischemia

  This study is looking at how fatty fibrosis affects people with chronic limb threatening ischemia (CLTI), a condition that causes poor blood flow and can lead to severe pain or even amputation, to find new ways to improve blood flow and muscle function in those struggling with this issue.

  NIH research University of Florida · Gainesville, United States · NIH-11002309

• Using machine learning to predict disease progression and survival in patients with severe limb ischemia.

  This study is working on a smart system that helps doctors understand how serious chronic limb-threatening ischemia (CLTI) is for patients and how it changes over time, so they can give the best treatment possible and improve health outcomes.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11001221

Related topics

Quick answers

How many Chronic Limb-Threatening Ischemia clinical trials are recruiting right now?

20, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in United States (5 trials), United Kingdom (5 trials), China (2 trials), Taiwan (2 trials), Egypt (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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