Understanding how certain immune cells affect muscle healing in patients with poor blood flow.
Determining the Role of Spp1+ Macrophages in Muscle Regeneration in Peripheral Arterial Disease
This study is looking at how a special type of immune cell affects muscle healing in people with peripheral arterial disease (PAD), with the goal of finding new ways to help improve recovery and prevent limb loss.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10984305 on NIH RePORTER |
What this research studies
This research investigates the role of a specific type of immune cell, known as Spp1+ macrophages, in the healing process of muscles in patients suffering from peripheral arterial disease (PAD). The study aims to uncover how these macrophages may hinder muscle regeneration and explore potential new therapies to improve healing and prevent limb loss. By examining the interactions between these immune cells and muscle stem cells, the research seeks to develop innovative cellular therapies that could enhance recovery for patients with PAD. The principal investigator, an experienced surgeon-scientist, will utilize both laboratory experiments and clinical insights to drive this research forward.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with peripheral arterial disease who are experiencing muscle regeneration issues.
Not a fit: Patients who do not have peripheral arterial disease or those with advanced stages of the disease where limb loss has already occurred may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve muscle healing and reduce the risk of limb loss for patients with peripheral arterial disease.
How similar studies have performed: Other research has shown promising results in understanding the role of immune cells in muscle regeneration, suggesting that this approach could yield significant insights and advancements.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Southerland, Kevin William — Duke University
- Study coordinator: Southerland, Kevin William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.