Improving blood vessel growth in patients with severe leg artery disease
Downregulation of 24-Dehydrocholesterol Reductase in Monocytes Improves Arteriogenesis in Peripheral Arterial Disease
['FUNDING_R03'] · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · NIH-10992647
This study is looking at how changing certain immune cells in people with critical limb ischemia can help grow new blood vessels and improve blood flow, which might reduce the need for amputation and promote healing.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MIAMI SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (CORAL GABLES, UNITED STATES) |
| Trial ID | NIH-10992647 on ClinicalTrials.gov |
What this research studies
This research focuses on patients with critical limb ischemia (CLI), a severe form of peripheral artery disease that can lead to pain, gangrene, and amputation. The study investigates how modifying certain immune cells, specifically monocytes, can enhance the formation of new blood vessels in the affected limbs. By downregulating an enzyme called 24-Dehydrocholesterol Reductase in these cells, the researchers aim to improve blood flow and reduce the need for amputation. Patients may benefit from a novel treatment approach that harnesses the body's immune response to promote healing and vascular growth.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from critical limb ischemia who are not eligible for surgical revascularization.
Not a fit: Patients with mild peripheral artery disease or those who have already undergone successful revascularization procedures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve blood flow and healing in patients with critical limb ischemia, potentially reducing the need for amputations.
How similar studies have performed: Previous research has shown promising results in enhancing blood vessel growth through immune cell modulation, suggesting that this approach may be effective.
Where this research is happening
CORAL GABLES, UNITED STATES
- UNIVERSITY OF MIAMI SCHOOL OF MEDICINE — CORAL GABLES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LASSANCE-SOARES, ROBERTA MARQUES — UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- Study coordinator: LASSANCE-SOARES, ROBERTA MARQUES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.