Isometric handgrip training for patients with peripheral artery disease
Effects of 12 Weeks of Isometric Handgrip Training in Blood Pressure in Patients With Peripheral Artery Disease
NA · University of Nove de Julho · NCT03663777
This study is testing whether a specific handgrip exercise can help lower blood pressure in people with high blood pressure and peripheral artery disease.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 45 Years and up |
| Sex | All |
| Sponsor | University of Nove de Julho (other) |
| Locations | 2 sites (São Paulo, São Paulo and 1 other locations) |
| Trial ID | NCT03663777 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of isometric handgrip training (IHT) on blood pressure in hypertensive patients suffering from peripheral arterial disease. A total of 30 participants will be randomly assigned to either an IHT group, which will undergo a structured training regimen for 12 weeks, or a control group that will be encouraged to increase their physical activity. The IHT group will perform multiple sets of isometric contractions, while cardiovascular measures will be assessed before and after the intervention to evaluate the impact on blood pressure and cardiac autonomic modulation. The study aims to determine if a more intensive IHT protocol can lead to significant reductions in blood pressure for this patient population.
Who should consider this trial
Good fit: Ideal candidates include postmenopausal women with peripheral artery disease and specific blood pressure criteria.
Not a fit: Patients with severe obesity, limb amputations, or those who change medications during the study may not benefit from this intervention.
Why it matters
Potential benefit: If successful, this intervention could provide a non-pharmacological approach to managing blood pressure in patients with peripheral artery disease.
How similar studies have performed: Previous studies have shown positive outcomes with isometric handgrip training in hypertensive patients, but its effectiveness in those with peripheral artery disease remains less explored.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women in post-menopause phase without hormone replacement therapy * Ankle-brachial index \<0.90 * Not severe obese (≥ 35kg/m2) * Not present amputation in the limbs * Have blood pressure levels lower than 160mmHg for systolic and 105mmHg for diastolic Exclusion Criteria: * patients will only be excluded if they make any medication changes before completing the intervention period or present any health problems that prevent physical activity.
Where this trial is running
São Paulo, São Paulo and 1 other locations
- Universidade Nove de Julho — São Paulo, São Paulo, Brazil (RECRUITING)
- Hospital Israelita Albert Einstein — São Paulo, São Paulo, Brazil (COMPLETED)
Study contacts
- Principal investigator: Raphael Dias, PhD — University of Nove de Julho
- Study coordinator: Raphael Dias, PhD
- Email: raphaelritti@gmail.com
- Phone: +5519999406878
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Peripheral Arterial Disease