Isometric handgrip training for patients with peripheral artery disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of isometric handgrip training (IHT) on blood pressure in hypertensive patients suffering from peripheral arterial disease. A total of 30 participants will be randomly assigned to either an IHT group, which will undergo a structured training regimen for 12 weeks, or a control group that will be encouraged to increase their physical activity. The IHT group will perform multiple sets of isometric contractions, while cardiovascular measures will be assessed before and after the intervention to evaluate the impact on blood pressure and cardiac autonomic modulation. The study aims to determine if a more intensive IHT protocol can lead to significant reductions in blood pressure for this patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women in post-menopause phase without hormone replacement therapy
* Ankle-brachial index \<0.90
* Not severe obese (≥ 35kg/m2)
* Not present amputation in the limbs
* Have blood pressure levels lower than 160mmHg for systolic and 105mmHg for diastolic

Exclusion Criteria:

* patients will only be excluded if they make any medication changes before completing the intervention period or present any health problems that prevent physical activity.

Where it's running

• Universidade Nove de Julho
  São Paulo, São Paulo, Brazil Recruiting
• Hospital Israelita Albert Einstein
  São Paulo, São Paulo, Brazil Completed

Study contacts

• Principal investigator: Raphael Dias, PhD — University of Nove de Julho
• Study coordinator: Raphael Dias, PhD
• Email: raphaelritti@gmail.com
• Phone: +5519999406878

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Preventing lower limb artery disease in adults with diabetes using a risk-prediction model and HAPA-based nursing

  A risk-prediction model is tested in adults with type 2 diabetes to see if a nursing plan based on the HAPA model can reduce peripheral artery disease in the legs.

  Recruiting Second Affiliated Hospital of Nanchang University · Nanchang, Jang XI · NCT07881588

• Predictors of Major Adverse Limb Events After Iliac Artery Stenting

  This study tests what factors predict serious limb-related problems after iliac artery stenting in adults with peripheral artery disease.

  Recruiting I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio · Milan, Mi · NCT07672249

• New prodrug CG-0255 Besylate vs Plavix in healthy adults

  This study tests whether CG-0255 Besylate works similarly to Plavix® in healthy adults to understand how the two drugs behave in the body.

  Recruiting Phase 1 Shanghai CureGene Pharmaceutical Co., Ltd. · Miami, Florida · NCT07619885

• Radial and Ulnar Access in Vascular Interventions Registry

  This registry tests how often radial or ulnar artery access is used and what happens afterward in routine vascular procedures.

  Recruiting Mersin Medicalpark Hastanesi · Mersin, Mezitli · NCT07614386

• Remote versus in-person 30-second sit-to-stand testing for people with peripheral artery disease

  This project will test whether doing the 30-second sit-to-stand test by video works as well as doing it in person for adults aged 18–65 with Fontaine stage I–II peripheral artery disease who have a smartphone.

  Recruiting Izmir Democracy University · Izmir, Balçova · NCT07497360

• Imaging plaque activity across the body in people with symptomatic peripheral arterial disease

  This project will use whole-body PET-CT and CT angiography with several tracers to see if imaging can detect inflammation, microcalcification, and clot activity in people with symptomatic peripheral arterial disease.

  Recruiting University of Edinburgh · Edinburgh, Midlothian · NCT07472049

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.