New nanoparticles to improve blood flow in patients with peripheral arterial disease
Official title: Novel nanoparticles to stimulate therapeutic angiogenesis in peripheral arterial disease
Funded at University of Texas Arlington · NIH-11083040 · Data updated 2026-11-12
This study is testing new tiny particles that can help grow new blood vessels in people with peripheral arterial disease (PAD), making it easier for them to heal and improve blood flow without needing surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Arlington NIH-funded |
| Lab location | 1 site (Arlington, United States) |
| Project start | May 2, 2022 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $522,798 |
| NIH project number | 5R01HL158204-04 |
| Project ID | NIH-11083040 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with peripheral arterial disease, particularly those who are elderly or unable to undergo surgical interventions.
✕Less likely to help
Patients with mild or early-stage peripheral arterial disease who do not experience significant symptoms may not benefit from this research.
What this research studies
This research focuses on developing innovative nanoparticles that can help stimulate the growth of new blood vessels in patients suffering from peripheral arterial disease (PAD). The approach involves creating biodegradable nanoparticles that can deliver therapeutic agents directly to areas with poor blood flow, promoting healing and improving circulation. By using advanced imaging techniques, researchers will be able to monitor the effectiveness of these nanoparticles in real-time. This could provide a less invasive alternative to current treatments, especially for elderly patients who may not be suitable for surgery.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for improving blood flow and reducing complications associated with peripheral arterial disease.
How similar studies have gone: Previous research has shown promise in using nanoparticles for targeted drug delivery and angiogenesis, indicating potential success for this novel approach.
Where this research is happening
-
University of Texas Arlington
Arlington, United States Active
Researchers
- Principal investigator: Nguyen, Kytai Truong — University of Texas Arlington
- Study coordinator: Nguyen, Kytai Truong
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.