Passive stretching to improve walking in patients with peripheral artery disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of passive calf muscle stretching on patients with peripheral artery disease (PAD), a condition that causes leg pain due to reduced blood flow. Over a 12-week period, participants will undergo passive stretching to boost nitric oxide levels and improve vascular health, while also monitoring inflammatory markers and cardiovascular changes. The study will also explore the potential benefits of combining stretching with dietary nitrate to enhance walking capacity by reducing oxidative stress. The goal is to better understand how these interventions can improve physical function and address exercise intolerance in PAD patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Ankle-brachial index of 0.90 or less Stable condition for at least 3 months

Exclusion Criteria:

Habitual exercise or cardiovascular rehabilitation program during the past 3 months Critical limb ischemia, amputation, or leg pain at rest Major surgery or lower extremity revascularization in the last 3 months Heart Failure Kidney disease Beet allergy Crohn's Current smoker

Where it's running

• University of Wisconsin La Crosse
  La Crosse, Wisconsin, United States Recruiting

Study contacts

• Principal investigator: Jacob T Caldwell, Ph.D. — Assistant Professor
• Study coordinator: Jacob T Caldwell, Ph.D.
• Email: jcaldwell@uwlax.edu
• Phone: 608-785-8684

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.