Understanding how kidney disease affects blood flow in the legs
Molecular mechanisms regulating peripheral arterial disease pathobiology in chronic kidney disease
['FUNDING_R01'] · UNIVERSITY OF FLORIDA · NIH-10745646
This study is looking at how chronic kidney disease might make symptoms of peripheral artery disease worse, and it aims to find new ways to help patients feel better and improve their blood flow.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-10745646 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between chronic kidney disease (CKD) and peripheral artery disease (PAD), which causes severe symptoms like pain and potential limb amputation. The study focuses on how certain harmful substances that build up in CKD patients can activate a specific molecular pathway, leading to worsened blood flow and muscle injury. By exploring this connection, the researchers aim to uncover new insights into the biological mechanisms at play and identify potential therapeutic targets. Patients may be involved in trials that test interventions aimed at mitigating these effects.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic kidney disease who also experience symptoms of peripheral artery disease.
Not a fit: Patients without chronic kidney disease or those who do not have symptoms of peripheral artery disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve blood flow and reduce the risk of amputation for patients with both chronic kidney disease and peripheral artery disease.
How similar studies have performed: While the specific molecular pathway being studied is novel, previous research has shown that addressing similar biological mechanisms can lead to significant improvements in related conditions.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RYAN, TERENCE E — UNIVERSITY OF FLORIDA
- Study coordinator: RYAN, TERENCE E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease