Understanding how kidney disease affects blood flow in the legs
Official title: Molecular mechanisms regulating peripheral arterial disease pathobiology in chronic kidney disease
Funded at University of Florida · NIH-10745646 · Data updated 2026-11-12
This study is looking at how chronic kidney disease might make symptoms of peripheral artery disease worse, and it aims to find new ways to help patients feel better and improve their blood flow.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | December 1, 2019 |
| Project end | November 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $588,983 |
| NIH project number | 5R01HL149704-05 |
| Project ID | NIH-10745646 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic kidney disease who also experience symptoms of peripheral artery disease.
✕Less likely to help
Patients without chronic kidney disease or those who do not have symptoms of peripheral artery disease may not benefit from this research.
What this research studies
This research investigates the relationship between chronic kidney disease (CKD) and peripheral artery disease (PAD), which causes severe symptoms like pain and potential limb amputation. The study focuses on how certain harmful substances that build up in CKD patients can activate a specific molecular pathway, leading to worsened blood flow and muscle injury. By exploring this connection, the researchers aim to uncover new insights into the biological mechanisms at play and identify potential therapeutic targets. Patients may be involved in trials that test interventions aimed at mitigating these effects.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve blood flow and reduce the risk of amputation for patients with both chronic kidney disease and peripheral artery disease.
How similar studies have gone: While the specific molecular pathway being studied is novel, previous research has shown that addressing similar biological mechanisms can lead to significant improvements in related conditions.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Ryan, Terence E — University of Florida
- Study coordinator: Ryan, Terence E
Related research
Other NIH-funded projects on the same topics.
-
Understanding how CKD worsens leg artery disease at the cellular level
This grant explores why people with chronic kidney disease have faster, more severe peripheral artery disease and how specific cellular pathways contribute to worse blood flow and limb risk.
-
Personalized CKD-MBD care using systems biology and AI
A patient-facing program aims to tailor mineral-balance therapy for people with chronic kidney disease by using a computer model and smart decision rules to predict who will respond best to treatments.
-
Mitigating DKA in people with type 1 diabetes and kidney disease using SGLT1/2 inhibitors
This project tests a new way to prevent dangerous diabetic ketoacidosis in people with type 1 diabetes and chronic kidney disease who are using SGLT inhibitors, by tracking ketones in real time and combining glucose-keton data for safer therapy.
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Chronic Kidney Disease in Children: following young people as they grow up with CKD
A long-term study in kids with chronic kidney disease tracks kidney function and heart health as they transition into adulthood.
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Chronic Kidney Disease in Children follow-up study
A long-term study that follows kids with kidney disease as they grow into young adults, collecting health data from home and official records.
-
Malaria-related kidney injury and its link to chronic kidney disease in children
This grant looks at why some children who have malaria develop kidney injury and later chronic kidney disease, focusing on how severe malaria affects the kidneys over time.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.