Evaluating VTE Prevention with Rivaroxaban and Aspirin After Lower Limb Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to assess the incidence of venous thromboembolism (VTE) in patients undergoing lower limb revascularization surgery. Participants will be treated with either rivaroxaban 2.5 mg twice daily combined with aspirin 100 mg or a single antiplatelet agent. The study will involve regular clinic visits for checkups and mandatory Doppler ultrasounds at 30 days post-surgery. The goal is to determine if the combination therapy reduces the incidence of VTE compared to standard treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Be adults of any age and gender.
2. Have critical limb ischemia with a proposed revascularization treatment (either via ATP or bypass surgery) at the Vascular Surgery Service of HC/EBSERH - UFPE.
3. Sign the informed consent form (ICF) (Appendix 2).

Exclusion Criteria:

1. Experience a symptomatic VTE event during hospitalization, as they will require full anticoagulation rather than prophylactic anticoagulation.
2. Have any contraindications to Rivaroxaban.
3. Do not return for the 30-day postoperative follow-up visit.

Where it's running

• Hospital das Clínicas, Federal University of Pernambuco
  Pernambuco, Pernambuco, Brazil Recruiting

Study contacts

• Study coordinator: Gabriela Oliveira Buril, MD
• Email: gabriela.buril@ufpe.br
• Phone: +5581991121872

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.