Condition

Neurodegenerative Diseases clinical trials and research

• 35Clinical trials
• 50NIH research projects
• 1New in 30 days
• 20Countries

Newest Neurodegenerative Diseases clinical trials

All recruiting trials (35)

• Registering medical data and care outcomes for ALS, SMA, and other motor disorders

  This registry slowly collects routine-care information from adults with ALS, SMA, or other motor disorders to see how they’re treated and how care affects outcomes.

  Recruiting Ambulanzpartner Soziotechnologie APST GmbH · Berlin, State of Berlin · NCT07900672

• Prenatal education to reduce environmental exposures during pregnancy

  Aimed at pregnant people, this program tests whether a classroom-style education can help reduce exposure to harmful pollutants from seafood and nearby pollution sources.

  Recruiting at 2 sites The University of Texas Medical Branch, Galveston · Galveston, Texas and 1 other locations · NCT07758114

• Hyperspectral retinal imaging to detect Alzheimer’s and other neurodegenerative changes

  This project will test whether a special retinal camera that scans many wavelengths of light can detect signs of Alzheimer’s and other neurodegenerative diseases in people with dementia or at risk.

  Recruiting Center for Eye Research Australia · Melbourne, Victoria · NCT07545473

• Increasing daily physical activity to slow cognitive decline in alpha-synuclein disorders

  This study will test whether using a motivational smartphone app to increase everyday physical activity can help slow cognitive decline in people aged 50–80 with isolated REM sleep behavior disorder (an early sign of alpha‑synuclein disease).

  Recruiting University Hospital, Bonn · Bonn, North Rhine West-Falia · NCT07324330

• VIRADIA: a virtual reality app for neurological and cognitive testing

  This project tests whether the VIRADIA virtual reality app gives comparable results to standard paper or in-person neurological and cognitive tests for adults with and without neurological conditions.

  Recruiting Gametherapy · Nitra, Nitra Region · NCT07268079

• Following memory decline in Alzheimer disease

  This project will use 7T MRI, EEG, blood and stool samples, and memory tests to see if they can track memory decline in people over 55 with Alzheimer's disease or mild cognitive impairment.

  Recruiting Norwegian University of Science and Technology · Trondheim, Trønderlag · NCT07118137

• Slow-SPEED: Can a smartphone app help people with prodromal Parkinson's stay more active?

  This trial tests whether a remote smartphone app can help people with a LRRK2 G2019S or GBA1 N370S mutation increase daily activity and see if exercise might slow prodromal Parkinson's signs.

  Recruiting Radboud University Medical Center · Rochester, New York and 1 other locations · NCT06993142

• Using saliva and extracellular vesicles to diagnose neurodegenerative diseases

  This study is testing a new way to diagnose neurodegenerative diseases like Alzheimer's and Parkinson's by analyzing saliva samples to see if it can help identify these conditions earlier and tailor treatments for patients.

  Recruiting at 5 sites Fondazione Don Carlo Gnocchi ETS · Florence, FI and 4 other locations · NCT06869135

• Understanding the relationship between sleep disordered breathing and multiple health conditions

  This study is trying to see how sleep problems affect people's overall health and quality of life by looking at different health conditions in patients with sleep disordered breathing.

  Recruiting Xiangya Hospital of Central South University · Changsha · NCT06755840

• Using PET/CT imaging to diagnose TSPO-related diseases

  This study is testing if a special type of imaging called PET/CT can help doctors better diagnose certain diseases related to brain inflammation and degeneration in adults with suspected or diagnosed tumors.

  Recruiting at 3 sites Tianjin Medical University · Hefei, Anhui and 2 other locations · NCT06725719

• Evaluating PET/CT for diagnosing Tau-related diseases

  This study is testing if a special type of brain scan can help doctors better diagnose Tau-related diseases in adults with suspected or newly diagnosed tumors.

  Recruiting at 4 sites Tianjin Medical University · Hefei, Anhui and 3 other locations · NCT06725706

• Evaluating Tau PET/CT for Diagnosing Tau-Related Diseases

  This study is testing a new type of imaging scan to see if it can help doctors better diagnose Tau-related diseases in adults with suspected or diagnosed tumors.

  Recruiting at 3 sites Tianjin Medical University · Hefei, Anhui and 2 other locations · NCT06690983

• Collecting data on neurodegenerative diseases progression markers

  This study is trying to find new signs that can help doctors understand how neurodegenerative diseases like Parkinson's progress, so they can improve early treatment options for patients.

  Recruiting IRCCS San Raffaele Roma · Cassino, Frosinone · NCT06596746

• Investigating Alzheimer's biomarkers in tears and blood

  This study is testing if we can find signs of Alzheimer's disease in tears and blood samples from people already diagnosed with Alzheimer's and other types of dementia.

  Recruiting Danish Dementia Research Centre · Copenhagen · NCT06567431

• Using exoskeletons for long-term rehabilitation of lower limb weakness

  This study is testing whether a hands-free exoskeleton can help adults with lower limb weakness from conditions like stroke or spinal cord injury improve their walking, balance, and quality of life over time.

  Recruiting Wandercraft · Paris · NCT06538974

• Using blood tests and voice analysis to help diagnose dementia

  This study is testing if a blood test and voice analysis can help doctors diagnose dementia earlier in people who have memory concerns.

  Recruiting at 2 sites Monash University · Box Hill, Victoria and 1 other locations · NCT06339190

• Increasing physical activity in patients at risk of Parkinson's disease using a smartphone app

  This study is testing a smartphone app to help people at risk of Parkinson's disease increase their physical activity and exercise intensity over two years.

  Recruiting Radboud University Medical Center · Nijmegen, Gelderland · NCT06193252

• Using probiotics to improve cognitive function in mild Alzheimer's Disease

  This study is testing if taking probiotics can help improve thinking skills and reduce inflammation in people with mild Alzheimer's Disease.

  Recruiting Early Phase 1 University of Nicosia · Nicosia · NCT06181513

• Evaluating a new treatment for cognitive function in mild Alzheimer's dementia

  This study is testing a new treatment that combines brain stimulation and cognitive training to see if it can help people with mild Alzheimer's dementia improve their thinking skills.

  Recruiting at 11 sites Advanced Technology & Communications · Incheon, Bupyeong 6(yuk)-dong, Bupyeong-gu and 10 other locations · NCT06088121

• Impact of long-term ventilation support on ALS patients and their families

  This study is testing how long-term breathing support affects the quality of life for people with ALS and their families.

  Recruiting at 8 sites Haukeland University Hospital · Bodø, Nordland and 8 other locations · NCT05744310

• Effects of speech-language intervention on bilingual speakers with primary progressive aphasia

  This study tests if special speech therapy designed for bilingual people can help those with primary progressive aphasia communicate better in both of their languages.

  Recruiting at 2 sites University of Texas at Austin · Austin, Texas and 2 other locations · NCT05741853

• Cohort study on Alzheimer's risk in first-degree relatives

  This study looks at how likely first-degree relatives of Alzheimer's patients are to develop the disease themselves and what factors might affect that risk.

  Recruiting Ruijin Hospital · Shanghai, Shanghai Municipality · NCT05597410

• Finding a biomarker for Parkinson's disease using imaging techniques

  This study is trying to find a specific marker for Parkinson's disease by using advanced brain imaging techniques on people with genetic mutations linked to the condition.

  Recruiting University of Exeter · Exeter, Devon · NCT05518617

• Understanding serotonin release in Parkinson's disease

  This study is trying to find a way to see changes in the brain of people with Parkinson's disease to help develop new treatments that could slow down the symptoms.

  Recruiting University of Exeter · Exeter, Devon · NCT05516732

• Investigating biomarkers for Parkinson's disease using advanced imaging techniques

  This study is trying to find a marker for Parkinson's disease by using advanced brain scans to see how the disease affects brain chemistry and structure over time.

  Recruiting University of Exeter · Exeter, Devon · NCT05516719

• Home exercise program for people with neurodegenerative diseases

  This study is testing a home exercise program to see if it can help people with neurodegenerative diseases improve their walking and balance.

  Recruiting Hugo W. Moser Research Institute at Kennedy Krieger, Inc. · Baltimore, Maryland · NCT05443906

• Using a PET tracer to study serotonin receptors in neurodegenerative diseases

  This study is testing how a new imaging method can help us understand serotonin receptors in people with neurodegenerative diseases like Parkinson's and see if a medication can improve their psychosis symptoms.

  Recruiting Phase 4 Vanderbilt University Medical Center · Nashville, Tennessee · NCT05357612

• Genetic analysis of hereditary spastic paraplegia

  This study is trying to find out the genetic causes of hereditary spastic paraplegia to help improve diagnosis and treatment for people living with this condition.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT05354622

• Using a passive home sensor to find digital signs of brain energy changes from nicotinamide riboside

  This project will try a contact-free home sensor to see if it can detect activity, sleep, and breathing changes related to nicotinamide riboside in people with mild cognitive impairment or mild Alzheimer's.

  Recruiting Mclean Hospital · Belmont, Massachusetts · NCT05245903

• Imaging inflammation in Parkinson's disease using PET scans

  This study is testing how inflammation affects Parkinson's disease by using special scans and blood tests to see what happens when participants are given a mild inflammatory substance.

  Recruiting University of Exeter · Exeter · NCT05205291

• Assessing swallowing function in patients with neurodegenerative diseases

  This study looks at how well people with neurodegenerative diseases, like Parkinson's and Motor Neuron Disease, can swallow and how it affects their quality of life.

  Recruiting at 16 sites Kliniken Beelitz GmbH · Innsbruck, Tyrol and 15 other locations · NCT04706234

• Neurodegenerative Diseases Registry

  This registry collects data from adults with neurodegenerative conditions to help doctors distinguish between Parkinsonian syndromes and related disorders and understand disease progression over time.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT04472130

• Observational research on chronic diseases and healthcare analytics

  This study looks at health records to see how well different treatments work for chronic diseases like HIV and hepatitis, aiming to improve patient care and support.

  Recruiting Epividian · Durham, North Carolina · NCT03813862

• Collecting cerebrospinal fluid to find new biomarkers for Alzheimer's disease

  This study is collecting spinal fluid from people getting tested for dementia to see if it can help find new ways to diagnose and treat Alzheimer's disease.

  Recruiting Central Hospital, Nancy, France · Nancy, Grand Est · NCT03621839

• Treatment for neurologic disorders using stem cells

  This study is testing whether using stem cells from patients' own bone marrow can help improve brain and nerve function in people with serious neurologic disorders that don't respond well to regular treatments.

  Recruiting at 3 sites MD Stem Cells · Westport, Connecticut and 2 other locations · NCT02795052

NIH-funded research (newest 40 of 50)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Developing small molecules to treat TDP-43 related brain diseases

  A potential new drug candidate (XL20) for diseases like Alzheimer’s and other dementias linked to TDP-43 protein problems is being developed and refined for people who live with these conditions.

  NIH research University of Arizona · Tucson, United States · NIH-11617893

• Tau filament structure in Alzheimer’s and related dementias

  Aims to map the detailed 3D shapes of tau protein filaments found in human brain diseases to help develop better diagnostics and treatments for Alzheimer’s-related dementias.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11601017

• Targeting RNA Splicing Abnormalities in ALS/FTD

  A research team aims to understand and correct abnormal RNA splicing in ALS and related brain diseases to help patients in the future.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11597831

• Blood-brain barrier–friendly imaging agents for neurodegenerative diseases

  A researcher team will test new imaging agents that can cross the brain barrier to help detect Alzheimer’s and related diseases earlier and more accurately.

  NIH research University of Illinois at Urbana-Champaign · Champaign, United States · NIH-11463370

• Brain cell–derived EV markers to differentiate Alzheimer’s and related dementias

  A Mayo Clinic team is testing brain-cell–specific tiny particles in blood to tell apart Alzheimer’s disease and similar dementias using advanced machine-learning analysis.

  NIH research Mayo Clinic Jacksonville · Jacksonville, United States · NIH-11445678

• Fisetin approach to reduce vulnerability to community infections in aging veterans

  A patient-friendly look at a study testing whether the natural compound fisetin can help aging Veterans stay healthier when they face common infections.

  NIH research Minneapolis VA Medical Center · Minneapolis, United States · NIH-11415406

• Non-Invasive nasal tests to detect Alzheimer’s and related memory problems

  A small business project is developing easy, non-invasive nasal tests to detect early signs of Alzheimer’s disease and related cognitive issues by measuring biomarkers.

  NIH research Sonas Biotechnologies INC · Eugene, United States · NIH-11402931

• PET tracer to visualize myeloperoxidase activity in neurodegenerative diseases

  A new imaging tool is being developed to non-invasively show where inflammatory enzyme MPO is active in the brains of people with Alzheimer’s disease or related conditions.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11387774

• Targeting RNA Splicing to Help ALS and FTD Patients

  A project at Massachusetts General Hospital aims to understand how faulty RNA splicing from ALS and FTD-related proteins affects brain cells and to find ways to fix it that could help patients.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11384652

• Improving methods to find the best time to treat neurodegenerative diseases

  This project builds better statistical tools to find when treatments will work best for people with neurodegenerative diseases such as Huntington disease.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11330412

• How ubiquitin-related protein problems contribute to brain degenerative diseases

  This project looks at how failures in the ubiquitin-linked protein cleanup system in brain cells lead to age-related neurodegenerative diseases and aims to help people with conditions like Parkinson's, ALS, and Huntington's.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11330315

• Adaptive 3D microelectrode array for organoid models of neurological and neurodegenerative diseases

  A new 3D microelectrode platform helps brain organoids from patient cells to model neurological and neurodegenerative diseases for better drug screening.

  NIH research Bmseed, LLC · Tempe, United States · NIH-11311188

• Double-stranded RNA and neuron death in Alzheimer's and related disorders

  This research looks at whether buildup of double-stranded RNA in brain cells triggers immune reactions that kill neurons in people with Alzheimer's, ALS, or frontotemporal dementia.

  NIH research University of Colorado · Boulder, UNITED STATES · NIH-11309681

• PET scan that finds harmful brain inflammation by targeting myeloperoxidase

  A new PET imaging tracer that lights up the enzyme myeloperoxidase to find early brain inflammation in people with Alzheimer's disease and related neurodegenerative conditions.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11297526

• Gene delivery for Alzheimer’s and related brain disorders

  This project develops ways to deliver therapeutic genes into the adult brain to help people with Alzheimer’s disease and related tau disorders.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11296841

• How ATXN1 affects brain support cells and dementia risk

  Researchers are finding out whether changes in the ATXN1 gene affect brain support cells called oligodendroglia and raise the risk of Alzheimer’s and related neurodegenerative conditions.

  NIH research Yale University · New Haven, United States · NIH-11251577

• Autophagon gene therapy to help brain cells clear harmful Alzheimer’s and Parkinson’s proteins

  A gene therapy that helps brain cells send toxic protein clumps to their natural recycling system for people with Alzheimer’s or Parkinson’s.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11238545

• Structure of amyloid filaments in brain diseases and aging

  Researchers study the tiny structures of protein filaments that build up in brain diseases like Alzheimer's and other dementias to understand how they form and vary.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11237291

• Therapy to clear harmful protein clumps in Alzheimer's, FTD, and ALS

  Developing small-molecule medicines that help brain and nerve cells remove harmful misfolded proteins in people with Alzheimer's disease, frontotemporal dementia, or ALS.

  NIH research Rezigene, LLC · Baltimore, United States · NIH-11194249

• Enhancing proteasome function to treat neurodegenerative diseases

  This study is looking at a new way to help people with neurodegenerative diseases like Alzheimer's by using special molecules that can boost a part of our cells that helps get rid of damaged proteins, with the hope of finding better treatments to slow down the disease.

  NIH research University of Virginia · Charlottesville, United States · NIH-11178909

• Correcting abnormal RNA splicing in ALS and frontotemporal dementia

  Researchers are using patient-derived lab-grown nerve and brain cells to develop ways to fix abnormal RNA splicing that harms people with ALS or frontotemporal dementia.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11177725

• Understanding how TBK1 affects lysosomes in neurodegenerative diseases

  This study is looking at how a protein called TBK1, which is important for brain health, helps keep our cells clean and how changes in this protein and another one can lead to conditions like ALS and frontotemporal dementia, with the hope of finding new ways to treat these diseases.

  NIH research Yale University · New Haven, United States · NIH-11165602

• Exploring how clonal hematopoiesis affects neurodegenerative diseases like Alzheimer's and ALS

  This study is looking at how a specific blood cell change called clonal hematopoiesis might affect the risk and progression of Alzheimer's disease and ALS, and it hopes to find new ways to prevent or treat these conditions, with the help of patients who can provide samples.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11158439

• Investigating shared mechanisms of tau toxicity in neurodegenerative diseases

  This study is looking at how problems with a protein called tau might be linked to diseases like Alzheimer's and Frontotemporal Dementia, with the hope of finding new ways to treat these conditions that could help patients in the future.

  NIH research Stanford University · Stanford, United States · NIH-11130576

• Investigating the role of double-stranded RNA in brain cell death related to Alzheimer's and similar diseases

  This study is looking at how a specific type of genetic material builds up in the brains of people with Alzheimer's and similar diseases, to understand how it harms brain cells and to find new ways to help treat these conditions.

  NIH research University of Colorado · Boulder, UNITED STATES · NIH-11122196

• Using biofluid markers to detect Alzheimer's disease early in Colombia

  This study is looking to make it easier to spot Alzheimer's and similar brain diseases by using special markers found in blood samples, and it's designed for people in Colombia to help doctors better understand and treat these conditions.

  NIH research University of Antioquia · Medellin, Colombia · NIH-11087256

• Improving clinical trial design for neurodegenerative diseases

  This study is looking at how symptoms of neurodegenerative diseases, like Huntington's disease, change over time to find the best moments for starting new treatments, which could lead to better clinical trials for those affected.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11083607

• Understanding how protein pathways affect age-related brain diseases

  This study is looking at how certain proteins that help keep our cells healthy can go wrong in diseases like Alzheimer's and Parkinson's, with the hope of finding new ways to treat these conditions and improve patients' lives.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11083079

• Investigating a new protein's role in brain cell health and neurodegenerative diseases

  This study is looking at how a protein called Nlk might help keep brain cells healthy by improving the way they clear out harmful proteins, and it's aimed at finding new ways to help people with Alzheimer's and similar conditions.

  NIH research Yale University · New Haven, United States · NIH-11076186

• Investigating how a protein regulates inflammation in brain diseases

  This study is looking at how a protein called PQBP1 affects inflammation in the brain related to Alzheimer's disease, specifically how it interacts with another protein called Tau that can cause brain issues, with the goal of finding out how these processes might impact memory and thinking.

  NIH research Scripps Research Institute, the · La Jolla, United States · NIH-11071258

• Gene therapy for treating age-related brain diseases

  This study is looking at a new way to help people with Alzheimer's by using a special kind of gene therapy that delivers helpful genes directly to brain cells, aiming to provide lasting benefits with just one treatment and without the need for invasive procedures.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11039966

• Exploring how ATXN1 affects brain cells in neurodegenerative diseases

  This study is looking at how changes in the ATXN1 gene might affect brain cells in diseases like Alzheimer's and ALS, with the hope of finding new ways to treat or prevent these conditions for patients.

  NIH research Yale University · New Haven, United States · NIH-11034132

• Understanding how tau protein affects brain function in aging and neurodegenerative diseases

  This study is looking at how a protein called tau affects brain connections as we age, especially in people with Alzheimer's, to help find ways to prevent memory loss and other problems related to aging.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11032725

• Finding new treatments for Alzheimer's disease by studying protein interactions with cell membranes

  This study is looking at how a protein linked to Alzheimer's disease interacts with cell membranes, and it's trying to find new ways to help people by discovering compounds that could reduce the harmful effects of that protein.

  NIH research University of Virginia · Charlottesville, United States · NIH-11010453

• A gene therapy tool to clear toxic proteins in neurodegenerative diseases

  This study is testing a new gene therapy called Autophagon that aims to help people with Alzheimer's and Parkinson's by clearing out harmful proteins in the brain, using a special delivery method to help the body remove these toxins naturally.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11001449

• Conference on Neurodegenerative Diseases and Treatments

  This conference is bringing together scientists and researchers to share ideas and discoveries about diseases like Alzheimer's and ALS, with the goal of finding better ways to understand and treat these conditions.

  NIH research Cold Spring Harbor Laboratory · Cold Spring Harbor, United States · NIH-10994945

• Creating a blood test to detect neurodegenerative diseases like Alzheimer's

  This study is working on a new blood test that can help doctors spot Alzheimer's and other brain diseases earlier by looking for specific proteins that are out of shape, making it easier to get the right treatment for you.

  NIH research 3d Bioanalytix, INC. · San Diego, United States · NIH-10922630

• Creating a therapy to combat protein issues in neurodegenerative diseases

  This study is looking at how problems with proteins in the brain might lead to diseases like Alzheimer's and ALS, and it's trying to find new ways to help our cells better handle these issues, which could lead to better treatments for these tough conditions.

  NIH research Rezigene, LLC · Baltimore, United States · NIH-10920047

• Investigating RNA splicing issues in neurodegenerative diseases like ALS and FTD

  This study is looking at how changes in certain proteins that bind to RNA can cause problems with RNA processing in diseases like ALS and frontotemporal dementia, and it aims to find out how these issues affect nerve cell function.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10907757

• Creating new therapies to protect brain cells in neurodegenerative diseases

  This study is exploring new treatments that help protect brain cells from damage in diseases like Alzheimer's by blocking the interaction between two important proteins, which could lead to better ways to slow down the disease and improve life for patients.

  NIH research Northwestern University · Chicago, UNITED STATES · NIH-10906898

Related topics

Quick answers

How many Neurodegenerative Diseases clinical trials are recruiting right now?

35, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 20 countries. The most sites are in United States (9 trials), China (5 trials), United Kingdom (4 trials), Germany (3 trials), Italy (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Early Phase 1: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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