Cohort study on Alzheimer's risk in first-degree relatives
Shanghai At Risk for Alzheimer's Disease: a Cohort Study
This study looks at how likely first-degree relatives of Alzheimer's patients are to develop the disease themselves and what factors might affect that risk.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 3418 (estimated) |
| Ages | 50 Years and up |
| Sex | All |
| Sponsor | Ruijin Hospital Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Trial ID | NCT05597410 on ClinicalTrials.gov |
What this trial studies
This observational cohort study aims to estimate the incidence of Alzheimer's disease (AD) among first-degree relatives of AD patients. It employs various methodologies, including neuropsychiatric assessments, MRI, and fluid biomarker analysis, to track cognitive changes over time in individuals at high risk for AD. Additionally, the study investigates environmental and behavioral factors that may influence the incidence of AD. The findings are expected to contribute to the development of prevention and treatment guidelines tailored for the Chinese population.
Who should consider this trial
Good fit: Ideal candidates are first-degree relatives of Alzheimer's patients who are at least 50 years old and have lived in Shanghai for over a year.
Not a fit: Patients with other diseases causing cognitive decline or significant psychological disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for predicting and preventing Alzheimer's disease in at-risk individuals.
How similar studies have performed: Similar cohort studies have shown promise in understanding Alzheimer's risk factors, but this specific approach focusing on first-degree relatives is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. the AD diagnostic criteria of probands meet the 2011 National Institute on Aging - Alzheimer's Association framework, and participants are the first-degree relatives (including parents, children and siblings of the same father and mother) of the proband; 2. not patients with dementia; 3. ≥ 50 years, males and females; 4. subjects have lived in Shanghai for more than 1 year and have no plan to move out of Shanghai within 5 years; 5. subjects are able to complete investigation, physical examination, imaging examination and biological specimen collection. Exclusion criteria: Individuals will be excluded if they have: 1. other diseases which could cause cognitive decline, e.g. cerebrovascular diseases, Creutzfeldt-Jakob disease and Parkinsons disease; 2. history of psychological disorders (according to Diagnostic and Statistical Manual of Mental Disorders, 5th Edition); 3. uncorrectable visual or auditory impairment that hampers the completion of related examination. 4. pre-menopausal women will also be excluded.
Where this trial is running
Shanghai, Shanghai Municipality
- Ruijin Hospital, Shanghai Jiao Tong University School of Medicine — Shanghai, Shanghai Municipality, China (Recruiting)
Study contacts
- Study coordinator: Gang Wang, MD, PhD
- Email: wg11424@rjh.com.cn
- Phone: 086-021-64370045
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.