Increasing daily physical activity to slow cognitive decline in alpha-synuclein disorders

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, double-blind, actively controlled intervention that aims to increase the volume and intensity of everyday physical activity over one year using a motivational smartphone application. Participants include people with polysomnography-confirmed isolated REM sleep behavior disorder (iRBD) and a low baseline activity level, plus healthy control participants for comparison. Cognitive function and activity levels will be tracked over time to see if increased movement preserves cognition. Recruitment and visits are conducted at the University Hospital Bonn, and participants must have basic smartphone skills and sufficient German language ability.

Why it matters

Who can join: the full rules

Inclusion Criteria:

iRBD:

* Age: 50-80 years
* Polysomnographically confirmed diagnosis of iRBD
* Maximum of 120 minutes of sports/outdoor activities per day
* Less than an average of 10,000 steps per day during the 4-week eligibility and baseline phase
* Basic smartphone skills
* Sufficient knowledge of German (native language, C1 or C2)
* Ownership of a suitable smartphone (minimum screen size 4.6 inches, Android version 9 or iOS version 15 or newer)
* Consent to be informed of any additional findings

Healthy controls:

* Age: 50-80 years
* Maximum of 120 minutes of sports/outdoor activities per day
* Less than an average of 10,000 steps per day during the 4-week eligibility and baseline phase
* Basic smartphone skills
* Sufficient knowledge of German (native language, C1 or C2)
* Ownership of a suitable smartphone (minimum screen size 4.6 inches, Android version 9 or iOS version 15 or newer)
* Consent to be informed of any additional findings

Exclusion Criteria:

iRBD:

* Relevant cardiovascular diseases
* Problems with dexterity or cognitive impairments that make it difficult to use a smartphone
* Cognitive impairments that limit the ability to make informed decisions and consent to participate in the study
* Ownership of one of the following devices: Huawei P8 Lite, Huawei P9 Lite, Xiaomi Mi 6, Huawei P20 Lite (FitBit is not compatible)

Healthy controls:

* Relevant cardiovascular diseases
* Problems with dexterity or cognitive impairments that make it difficult to use a smartphone
* Cognitive impairments that limit the ability to make informed decisions and consent to participate in the study
* Ownership of one of the following devices: Huawei P8 Lite, Huawei P9 Lite, Xiaomi Mi 6, Huawei P20 Lite (FitBit is not compatible)
* clinically diagnosed iRBD

Where it's running

• University Hospital of Bonn
  Bonn, North Rhine West-Falia, Germany Recruiting

Study contacts

• Principal investigator: Michael B Sommerauer, Dr. — University Hospital of Bonn
• Study coordinator: Martin M Rodemann
• Email: Martin.Rodemann@ukbonn.de
• Phone: +49 0228 287 - 19436

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Slow-SPEED: Can a smartphone app help people with prodromal Parkinson's stay more active?

  This trial tests whether a remote smartphone app can help people with a LRRK2 G2019S or GBA1 N370S mutation increase daily activity and see if exercise might slow prodromal Parkinson's signs.

  Recruiting Radboud University Medical Center · Rochester, New York and 1 other locations · NCT06993142

• Increasing physical activity in patients at risk of Parkinson's disease using a smartphone app

  This study is testing a smartphone app to help people at risk of Parkinson's disease increase their physical activity and exercise intensity over two years.

  Recruiting Radboud University Medical Center · Nijmegen, Gelderland · NCT06193252

• Axial and cognitive symptoms and biomarkers in brain‑first versus body‑first Parkinson's disease

  This project will test whether clinical exams, sleep testing, heart and brain scans, and blood/CSF biomarkers can distinguish brain‑first from body‑first early Parkinson's patients and predict worsening of balance and thinking problems.

  Recruiting Azienda USL Reggio Emilia - IRCCS · Reggio Emilia · NCT07187843

• Evaluating a new treatment for cognitive function in mild Alzheimer's dementia

  This study is testing a new treatment that combines brain stimulation and cognitive training to see if it can help people with mild Alzheimer's dementia improve their thinking skills.

  Recruiting at 11 sites Advanced Technology & Communications · Incheon, Bupyeong 6(yuk)-dong, Bupyeong-gu and 10 other locations · NCT06088121

• Registering medical data and care outcomes for ALS, SMA, and other motor disorders

  This registry slowly collects routine-care information from adults with ALS, SMA, or other motor disorders to see how they’re treated and how care affects outcomes.

  Recruiting Ambulanzpartner Soziotechnologie APST GmbH · Berlin, State of Berlin · NCT07900672

• Virtual reality plus bilateral brain stimulation to improve arm and hand recovery after stroke

  We will try combining virtual reality exercises with bilateral transcranial direct current stimulation (bi‑tDCS) to improve arm and hand movement in adults at least three months after a unilateral stroke.

  Recruiting King Saud University · Riyadh · NCT07288385

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.