Clinical trial Recruiting at 1 site Observational Ages 18 to 80

Neurodegenerative Diseases Registry

Official title: Biomarkers in Neurodegenerative Diseases

Run by Chinese University of Hong Kong · NCT04472130 · Data updated 2026-11-12

This registry collects data from adults with neurodegenerative conditions to help doctors distinguish between Parkinsonian syndromes and related disorders and understand disease progression over time.

Quick facts

Study typeObservational
Ages18 Years to 80 Years
SexAll
Enrollment1400 (estimated)
SponsorChinese University of Hong Kong
Academic / other
Locations1 site (Hong Kong)
StatusRecruiting
StartedOctober 9, 2019
Main results expectedAugust 1, 2031
Study endsAugust 1, 2031
Registry record updatedSeptember 18, 2026
Trial IDNCT04472130 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18–80 with neurodegenerative diseases such as Parkinson disease, multiple system atrophy, or progressive supranuclear palsy who can participate in follow-up visits.

Probably not a fit

Individuals with conditions outside the specified parkinsonian syndromes or who cannot complete follow-up assessments may not derive direct personal benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort study documents baseline and follow-up information on people with neurodegenerative diseases, including Parkinson disease, MSA, and PSP. Participants undergo standardized clinical assessments, questionnaires, and blood collection at baseline and at 1–2 year follow-ups, with additional eye-movement video recordings as needed. The goal is to improve differentiation among parkinsonian syndromes and track changes in function, cognition, and disease burden over time. Data will be collected across groups using disease-specific scales and common measures, enabling longitudinal analyses while adhering to standard follow-up intervals.

Why it matters

Potential benefit: Participants may contribute to a better understanding of disease trajectories and help improve future diagnostic accuracy and care for neurodegenerative conditions.

How similar studies have gone: Observational registries in neurodegenerative diseases have provided insights into progression and differential diagnosis, supporting the value of this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age should be between 18-80 years old.

Exclusion Criteria:

* Patients with ongoing central nervous system infection and/or acute stroke or active brain tumor.

Where it's running

  • Chinese University of Hong Kong
    Hong Kong, Hong Kong
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.