Home exercise program for people with neurodegenerative diseases
Official title: Study of Adapted Exercise and Mindfulness Interventions to Improve Motor Function and Sleep Quality in Individuals With Neurodegenerative Disease
Run by Hugo W. Moser Research Institute at Kennedy Krieger, Inc. · NCT05443906 · Data updated 2026-11-12
This study is testing a home exercise program to see if it can help people with neurodegenerative diseases improve their walking and balance.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 5 Years to 75 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. Academic / other |
| Locations | 1 site (Baltimore, Maryland) |
| Status | Recruiting |
| Started | February 13, 2023 |
| Main results expected | July 30, 2028 |
| Study ends | July 30, 2028 |
| Registry record updated | September 16, 2026 |
| Trial ID | NCT05443906 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals diagnosed with specific neurodegenerative conditions such as X-linked adrenoleukodystrophy, leukoencephalopathy with DARS2 mutations, and various forms of cerebellar ataxia.
✕Probably not a fit
Patients with neurodegenerative diseases not included in the specified criteria or those unable to participate in home exercise may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to develop targeted therapeutic interventions to improve walking and balance in individuals with neurodegenerative diseases. It will assess baseline disease severity and apply appropriate home exercise programs tailored to specific disease pathologies. The study will also evaluate the feasibility of remotely supervised exercise and optimize outcome measures for clinical monitoring. Ultimately, it seeks to measure the effectiveness of these interventions on balance and walking abilities post-exercise.
Why it matters
Potential benefit: If successful, this program could enhance mobility and quality of life for patients with neurodegenerative diseases.
How similar studies have gone: Other studies have shown promise in using exercise interventions for neurodegenerative diseases, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * The eligibility criteria for males is X-linked adrenoleukodystrophy as determined by biochemical determination or genetic testing. * The eligibility criteria for females is X-linked adrenoleukodystrophy as determined by biochemical determination, genetic testing, or pedigree analysis. * The Leukoenceophalopathy with brainstem and spinal cord involvement and lactate elevation inclusion criterion is a confirmed DARS2 mutation through genetic analysis. * For people with cerebellar ataxia, people with diagnoses of cerebellar damage from stroke, tumor or degeneration will be included. Those with a genetically confirmed cerebellar disorder will be asked to provide their genetic testing to note their particular type of ataxia. * We will also include patients with other neurodegenerative diseases similar to these disorders as determined by chart review and clinical exam. Healthy Volunteers * Able to stand for 30 seconds without upper extremity support * Ambulatory (including use of a cane or a walker) * Able to walk for 2 minutes Exclusion Criteria: * Other medical or psychological conditions which in the clinical judgement of the investigator would interfere with acquiring the study information or performing the exercises safely including but not limited to: Uncontrolled hypertension, orthopedic conditions, diabetes, seizure disorder, peripheral vestibular loss, severe aphasia, dementia, pregnancy
Where it's running
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Kennedy Krieger Institute
Baltimore, Maryland, United States Recruiting
Study contacts
- Principal investigator: Jennifer Keller, PT — Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
- Study coordinator: Jennifer L Keller, PT, MS
- Email: keller@kennedykrieger.org
- Phone: 443-923-2716
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.