Investigating how a protein regulates inflammation in brain diseases
PQBP1 as a central regulator of inflammation in neurodegenerative diseases
['FUNDING_FELLOWSHIP'] · SCRIPPS RESEARCH INSTITUTE, THE · NIH-11071258
This study is looking at how a protein called PQBP1 affects inflammation in the brain related to Alzheimer's disease, specifically how it interacts with another protein called Tau that can cause brain issues, with the goal of finding out how these processes might impact memory and thinking.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCRIPPS RESEARCH INSTITUTE, THE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11071258 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of a protein called PQBP1 in regulating inflammation associated with neurodegenerative diseases like Alzheimer's. It examines how the accumulation of protein aggregates, such as Tau, triggers inflammatory responses in the brain, which can lead to cognitive decline. The study aims to explore the interaction between PQBP1 and Tau, and how this relationship may influence the activation of immune responses in the brain. By using various experimental approaches, the research seeks to uncover the mechanisms behind these processes and their implications for neurodegenerative conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or other tauopathies who are experiencing cognitive decline.
Not a fit: Patients with neurodegenerative diseases not associated with Tau protein aggregation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for reducing inflammation and slowing the progression of neurodegenerative diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of protein interactions in neuroinflammation, suggesting that this approach may yield valuable insights.
Where this research is happening
LA JOLLA, UNITED STATES
- SCRIPPS RESEARCH INSTITUTE, THE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ALLEN, DALE S — SCRIPPS RESEARCH INSTITUTE, THE
- Study coordinator: ALLEN, DALE S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.