Investigating how a protein regulates inflammation in brain diseases
Official title: PQBP1 as a central regulator of inflammation in neurodegenerative diseases
Funded at Scripps Research Institute, the · NIH-11071258 · Data updated 2026-11-12
This study is looking at how a protein called PQBP1 affects inflammation in the brain related to Alzheimer's disease, specifically how it interacts with another protein called Tau that can cause brain issues, with the goal of finding out how these processes might impact memory and thinking.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $35,974 |
| NIH project number | 1F31NS141616-01 |
| Project ID | NIH-11071258 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or other tauopathies who are experiencing cognitive decline.
✕Less likely to help
Patients with neurodegenerative diseases not associated with Tau protein aggregation may not benefit from this research.
What this research studies
This research focuses on understanding the role of a protein called PQBP1 in regulating inflammation associated with neurodegenerative diseases like Alzheimer's. It examines how the accumulation of protein aggregates, such as Tau, triggers inflammatory responses in the brain, which can lead to cognitive decline. The study aims to explore the interaction between PQBP1 and Tau, and how this relationship may influence the activation of immune responses in the brain. By using various experimental approaches, the research seeks to uncover the mechanisms behind these processes and their implications for neurodegenerative conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for reducing inflammation and slowing the progression of neurodegenerative diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of protein interactions in neuroinflammation, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Scripps Research Institute, the
La Jolla, United States Active
Researchers
- Principal investigator: Allen, Dale S — Scripps Research Institute, the
- Study coordinator: Allen, Dale S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.