Improving clinical trial design for neurodegenerative diseases
Official title: Developing a Robust and Efficient Strategy for Censored Covariates to Improve Clinical Trial Design for Neurodegenerative Diseases
Funded at Univ of North Carolina Chapel Hill · NIH-11083607 · Data updated 2026-11-12
This study is looking at how symptoms of neurodegenerative diseases, like Huntington's disease, change over time to find the best moments for starting new treatments, which could lead to better clinical trials for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | June 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $455,253 |
| NIH project number | 5R01NS131225-03 |
| Project ID | NIH-11083607 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with neurodegenerative diseases, particularly those at risk for Huntington's disease.
✕Less likely to help
Patients with acute neurodegenerative conditions or those who do not have a genetic predisposition to Huntington's disease may not benefit from this research.
What this research studies
This research focuses on developing better statistical models to understand how symptoms of neurodegenerative diseases, like Huntington's disease, progress over time. By accurately modeling the trajectory of symptoms before and after a clinical diagnosis, the research aims to identify the optimal timing for therapeutic interventions. This could help in designing clinical trials that are more effective in testing new treatments. The approach involves addressing the challenges posed by incomplete data due to the slow progression of these diseases.
Why it matters
Potential benefit: If successful, this research could lead to more effective clinical trials and ultimately better treatment options for patients with neurodegenerative diseases.
How similar studies have gone: While the approach of modeling symptom trajectories is established, this specific application to right-censored covariates in neurodegenerative diseases is relatively novel and has not been extensively tested.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Garcia, Tanya Pamela — Univ of North Carolina Chapel Hill
- Study coordinator: Garcia, Tanya Pamela
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.