Assessing swallowing function in patients with neurodegenerative diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study systematically records the results of routine laryngeal examinations and specific characteristics of dysphagia in patients diagnosed with neurodegenerative disorders such as Multiple System Atrophy, Parkinson's Disease, and Motor Neuron Disease. It utilizes fiberoptic endoscopic evaluation of swallowing (FEES) and collects demographic and disease-specific data, along with administering two questionnaires related to swallowing disturbances and quality of life. The study aims to enhance understanding of laryngopharyngeal dysfunction and its implications for patient prognosis and treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* diagnosis of probable or possible multiple system atrophy according to current consensus criteria (Gilman et al. 2008) or
* diagnosis of probable or possible PSP according to the the Movement Disorders Society (MDS) diagnostic criteria (Höglinger et al. 2017) or
* diagnosis of Parkinson's disease according to the MDS diagnostic criteria (Postuma et al 2015)
* Hoehn and Yahr Stage within the range of I-V or
* diagnosis of motor neurone disease or
* diagnosis of a neurodegenerative disease other than specified above

AND underwent laryngopharyngeal assessment according to the systematic task protocol during FEES (Warnecke et al. 2019).

Exclusion Criteria:

\- Patients who do not sign the consent form

Where it's running

• Department of Neurology and Department of ENT, Medical University Innsbruck
  Innsbruck, Tyrol, Austria Recruiting
• Department of Neurology, Medical University of Ulm
  Ulm, Baden-Wurttemberg, Germany Recruiting
• Movement Disorders Hospital - Kliniken Beelitz
  Beelitz-Heilstätten, Brandenburg, Germany Recruiting
• Department of Neurology, Medical School Hannover
  Hanover, Lower Saxony, Germany Recruiting
• Department of Neurology, University Hospital Münster
  Münster, North Rhine-Westphalia, Germany Recruiting
• Department of Neurology, University Hospital Carl Gustav Carus
  Dresden, Saxony, Germany Recruiting

Study contacts

• Principal investigator: Florin Gandor, MD — Movement Disorders Hospital Beelitz-Heilstätten, Germany
• Study coordinator: Florin Gandor, MD
• Email: gandor@kliniken-beelitz.de
• Phone: +493320422781

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.