Finding new treatments for Alzheimer's disease by studying protein interactions with cell membranes
A cost-effective, high-throughput screening platform for modulator discovery of a-synuclein membrane interactions involved in neurodegenerative diseases
['FUNDING_R21'] · UNIVERSITY OF VIRGINIA · NIH-11010453
This study is looking at how a protein linked to Alzheimer's disease interacts with cell membranes, and it's trying to find new ways to help people by discovering compounds that could reduce the harmful effects of that protein.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-11010453 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how a protein called α-synuclein interacts with cell membranes, which is believed to contribute to Alzheimer's disease and related dementias. Researchers have developed innovative tools to observe these interactions in detail, aiming to discover new compounds that can modify or inhibit the harmful effects of α-synuclein. By identifying potential therapeutic agents, this research hopes to provide new avenues for treatment that could improve the lives of those affected by these neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with neurodegenerative diseases not related to Alzheimer's or those without any cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that slow down or prevent the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in targeting protein interactions in neurodegenerative diseases, suggesting that this approach could yield valuable insights and potential breakthroughs.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BAO, HUAN — UNIVERSITY OF VIRGINIA
- Study coordinator: BAO, HUAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome