Following memory decline in Alzheimer disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project enrolls Norwegian-speaking adults over 55 with a confirmed diagnosis of Alzheimer's disease or mild cognitive impairment who live at home. Participants undergo high-resolution 7T MRI, EEG recordings, blood and stool collection, and neuropsychological testing (MoCA) to characterize structural, functional, and biological changes related to memory. People with severe cognitive impairment (planned cutoff CDR > 2), other neurodegenerative diagnoses, brain tumors, prior cranial surgery, or contraindications to the imaging modalities are excluded. The aim is to combine multimodal imaging and biomarkers to identify signals that track memory deterioration over time.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Confirmed diagnosis based on current ICD criteria for AD or MCI .
* \>55years.
* Norwegian native speaker
* Lives at home and not in a health institution

Exclusion Criteria:

* Patients with severe cognitive impairment that prevents assessment with the selected modalities (planned cut-off: CDR \> 2).
* Presence of brain tumors.
* History of traumatic brain injury.
* History of cranial surgery.
* Contraindications to the selected imaging modalities (e.g., 7T MRI or EEG).
* Diagnosis of other neurodegenerative diseases such as Parkinson's disease or ALS.

  7T MRI contraindications:
* Large tattoos close to the head region, permanent makeup or unremoveable piercings
* Certain models of pacemakers (if pacemaker implantet, MRI physicist at 7T-lab will be conferred)
* Implantet metal in body (clips, stents, prothesis, skrews, plates, teeth etc.)

Where it's running

• Norwegian University of Sciene and Technology / Norges teknisk-naturvitenskapelige universitet (NTNU)
  Trondheim, Trønderlag, Norway Recruiting

Study contacts

• Principal investigator: Axel Sandvig Professor, MD PhD — Norwegian University of Science and Technology (NTNU)
• Study coordinator: Axel Sandvig Professor, MD & PhD
• Email: axel.sandvig@ntnu.no
• Phone: +4745840578

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.