Investigating a new protein's role in brain cell health and neurodegenerative diseases
Official title: Evaluation of a novel NLK function in lysosome biogenesis and neurodegenerative diseases
Funded at Yale University · NIH-11076186 · Data updated 2026-11-12
This study is looking at how a protein called Nlk might help keep brain cells healthy by improving the way they clear out harmful proteins, and it's aimed at finding new ways to help people with Alzheimer's and similar conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | August 1, 2021 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $792,034 |
| NIH project number | 5R01AG074609-05 |
| Project ID | NIH-11076186 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults over 21 years old who are diagnosed with Alzheimer's disease or related dementias.
✕Less likely to help
Patients with neurodegenerative diseases not associated with TDP-43 proteinopathy may not benefit from this research.
What this research studies
This research focuses on understanding how a protein called Nemo-like kinase (Nlk) affects the function of lysosomes, which are essential for clearing toxic proteins in the brain. By studying animal models of Alzheimer's disease and related dementias, the researchers aim to determine if enhancing Nlk's activity can help prevent or reduce the harmful protein aggregates associated with these conditions. The study employs various scientific techniques to explore the molecular mechanisms involved and assess potential therapeutic effects.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or alter the progression of Alzheimer's disease and related dementias.
How similar studies have gone: Previous research has shown promise in targeting lysosomal function to address neurodegenerative diseases, suggesting potential for success in this approach.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Lim, Janghoo — Yale University
- Study coordinator: Lim, Janghoo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.