Exploring how ATXN1 affects brain cells in neurodegenerative diseases
Official title: Investigation of the role of ATXN1 in oligodendroglia and neurodegenerative diseases
Funded at Yale University · NIH-11034132 · Data updated 2026-11-12
This study is looking at how changes in the ATXN1 gene might affect brain cells in diseases like Alzheimer's and ALS, with the hope of finding new ways to treat or prevent these conditions for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | March 1, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $613,830 |
| NIH project number | 5R01AG076154-04 |
| Project ID | NIH-11034132 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with genetic predispositions to Alzheimer's disease, ALS, or related neurodegenerative conditions.
✕Less likely to help
Patients with neurodegenerative diseases not associated with ATXN1 mutations may not benefit from this research.
What this research studies
This research investigates the role of the ATXN1 gene and its mutations in various neurodegenerative diseases, including Alzheimer's and amyotrophic lateral sclerosis (ALS). The study focuses on understanding how different mutations in the ATXN1 gene impact brain cells, particularly oligodendroglia, which are crucial for nerve function. By examining the genetic variations and their effects on disease progression, the research aims to uncover potential therapeutic targets for these conditions. Patients may benefit from insights that could lead to new treatments or preventive strategies for neurodegenerative diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that slow down or prevent the progression of neurodegenerative diseases.
How similar studies have gone: Previous research has shown promising results in understanding the genetic factors of neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Lim, Janghoo — Yale University
- Study coordinator: Lim, Janghoo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.