Using probiotics to improve cognitive function in mild Alzheimer's Disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of probiotics on patients with mild Alzheimer's Disease by comparing cognitive function and neuroinflammation levels between those receiving probiotics and a placebo group. Participants will undergo neuropsychological testing, blood tests for inflammatory markers, and assessments of their microbiome composition and dietary habits. The goal is to determine if probiotics can enhance cognitive performance and modify neurophysiological measures in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults ≥65 years, able to give consent
* Mini-Mental State Examination (MMSE) scores 19-23 (mild AD)
* approximately equal male:female ratio

Exclusion Criteria:

* Inability to give consent
* other neurological disease
* relevant psychiatric disorders (e.g. major depression)
* gastrointestinal/metabolic conditions
* history of alcohol/substance dependence
* use of systemic antibiotics in the previous 6 months
* corticosteroid use
* immune stimulating medications
* immunosuppressive agents
* probiotics consumption in the previous 6 months.
* immunosuppression
* structural heart disease
* neutropenia
* radiation
* active intestinal disease

Where it's running

• The Cyprus Institute of Neurology and Genetics
  Nicosia, Cyprus Recruiting

Study contacts

• Study coordinator: Nicoletta Nicolaou
• Email: nicolaou.nic@unic.ac.cy
• Phone: +35722471903

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.