Condition

Nervous System Diseases clinical trials and research

• 39Clinical trials
• 1NIH research projects
• 1New in 30 days
• 19Countries

Newest Nervous System Diseases clinical trials

All recruiting trials (39)

• Registering medical data and care outcomes for ALS, SMA, and other motor disorders

  This registry slowly collects routine-care information from adults with ALS, SMA, or other motor disorders to see how they’re treated and how care affects outcomes.

  Recruiting Ambulanzpartner Soziotechnologie APST GmbH · Berlin, State of Berlin · NCT07900672

• Music-4-MS: A 12-week music-based program to support thinking skills in people with MS

  A 12-week music-based program is tested to see if it helps cognitive function and mood in people living with multiple sclerosis.

  Recruiting University of Texas at Austin · Austin, Texas · NCT07759115

• AOC 1044 in Duchenne Muscular Dystrophy with Exon 44 Skipping

  This study tests whether intravenous AOC 1044 helps boys with Duchenne muscular dystrophy caused by mutations amenable to exon 44 skipping.

  Recruiting at 20 sites Phase 3 Avidity Biosciences, Inc. · Westmead, New South Wales and 19 other locations · NCT07587242

• Increasing daily physical activity to slow cognitive decline in alpha-synuclein disorders

  This study will test whether using a motivational smartphone app to increase everyday physical activity can help slow cognitive decline in people aged 50–80 with isolated REM sleep behavior disorder (an early sign of alpha‑synuclein disease).

  Recruiting University Hospital, Bonn · Bonn, North Rhine West-Falia · NCT07324330

• Virtual reality plus bilateral brain stimulation to improve arm and hand recovery after stroke

  We will try combining virtual reality exercises with bilateral transcranial direct current stimulation (bi‑tDCS) to improve arm and hand movement in adults at least three months after a unilateral stroke.

  Recruiting King Saud University · Riyadh · NCT07288385

• Shoulder Health After Rehab: Home-Based Strength Training for wheelchair users

  This study tests a home-based shoulder strength training program for manual wheelchair users who recently left rehabilitation to see if starting the training at 3 months versus 12 months after discharge affects shoulder health.

  Recruiting Swiss Paraplegic Research, Nottwil · Nottwil, Canton of Lucerne · NCT07245706

• Intra-arterial clot-dissolving treatment for medium-vessel ischemic stroke

  The team will test whether giving tenecteplase directly into the artery helps adults with acute ischemic stroke caused by medium-vessel blockage or severe narrowing.

  Recruiting at 6 sites The Second Hospital of Anhui Medical University · Fuyang, Anhui and 5 other locations · NCT07185022

• Slow-SPEED: Can a smartphone app help people with prodromal Parkinson's stay more active?

  This trial tests whether a remote smartphone app can help people with a LRRK2 G2019S or GBA1 N370S mutation increase daily activity and see if exercise might slow prodromal Parkinson's signs.

  Recruiting Radboud University Medical Center · Rochester, New York and 1 other locations · NCT06993142

• Endovascular treatment for stroke beyond 24 hours

  This study is testing whether a specific stroke treatment can help people who have had a stroke more than 24 hours ago feel better and regain independence compared to just receiving standard care.

  Recruiting The Second Hospital of Anhui Medical University · Hefei, Anhui · NCT06959199

• Portable EEG to triage suspected stroke patients in ambulances

  This trial will test whether a portable dry‑electrode EEG headset (StrokePointer) can detect large vessel occlusion strokes in adults with suspected acute stroke so ambulance crews can take them directly to hospitals that perform thrombectomy.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, North Holland · NCT06871969

• Remote ischemic conditioning after aneurysm clipping for ruptured brain aneurysms

  This test tries brief cycles of limb cuff inflation (remote ischemic conditioning) to see if it is safe and helps recovery in adults after surgical clipping of a ruptured brain aneurysm (aneurysmal subarachnoid hemorrhage).

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT06819657

• Evaluating therapy for patients with minor strokes and large vessel occlusion

  This study is testing different treatment options for patients with minor strokes caused by blocked large blood vessels to see which ones help them recover better.

  Recruiting Sir Run Run Shaw Hospital · Hangzhou, Zhejiang · NCT06633809

• Video call assessment for suspected stroke

  This study tests if using video calls between neurologists and emergency responders can help quickly and accurately assess patients who might be having a stroke.

  Recruiting University of Southern Denmark · Aabenraa, Region Syddanmark · NCT06570681

• Evaluating the impact of artery calcification on stroke treatment outcomes

  This study is trying to see if the amount of calcium in the arteries affects how well stroke patients do after a specific treatment for blocked blood vessels.

  Recruiting Zhujiang Hospital · Guangzhou, Guangdong · NCT06418698

• Using deep brain stimulation to improve speech and arm function after stroke

  This study is testing if deep brain stimulation can help improve hand movement and speech in people who have had a stroke.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06303869

• Using AI to diagnose and treat diseases in older adults

  This study is testing how AI can help diagnose and treat diseases like Parkinson's and Alzheimer's in older adults by looking at things like handwriting and speech.

  Recruiting Qilu Hospital of Shandong University · Jinan, Shandong · NCT06295263

• Community Occupational Therapy Program for Preventing Falls in Elderly with Dementia

  This study tests a community program that helps elderly people with dementia stay safe at home and avoid falls by working with their caregivers.

  Recruiting University Hospital, Limoges · Limoges · NCT06237218

• Increasing physical activity in patients at risk of Parkinson's disease using a smartphone app

  This study is testing a smartphone app to help people at risk of Parkinson's disease increase their physical activity and exercise intensity over two years.

  Recruiting Radboud University Medical Center · Nijmegen, Gelderland · NCT06193252

• Monitoring brain-derived tau levels in acute ischemic stroke patients

  This study is testing how brain-derived tau levels change in stroke patients over 48 hours to see if it can help understand their condition and improve treatment decisions.

  Recruiting Ludwig-Maximilians - University of Munich · Munich, Bavaria · NCT06121336

• Understanding motor behavior in high-risk infants

  This study is trying to understand how movement and muscle development in high-risk infants, like those born early or with brain injuries, compare to typically developing infants to help find better ways to support their growth.

  Recruiting University Hospital, Geneva · Geneva · NCT06111898

• Evaluating a new treatment for cognitive function in mild Alzheimer's dementia

  This study is testing a new treatment that combines brain stimulation and cognitive training to see if it can help people with mild Alzheimer's dementia improve their thinking skills.

  Recruiting at 11 sites Advanced Technology & Communications · Incheon, Bupyeong 6(yuk)-dong, Bupyeong-gu and 10 other locations · NCT06088121

• Cohort study on neurogenetic diseases

  This study is trying to help people with rare inherited brain disorders by collecting health information and samples over three years to improve research and future treatments.

  Recruiting University Hospital, Bordeaux · Bordeaux · NCT06048523

• Testing Tianeptine for treating cognitive issues after COVID-19.

  This study is testing if Tianeptine can help adults who have recovered from COVID-19 and are experiencing 'Covid Fog' feel better and think more clearly.

  Recruiting Phase 2 Military Institute od Medicine National Research Institute · Warsaw · NCT06012552

• Multi-domain lifestyle intervention for older adults at risk of cognitive decline in China

  This study is testing a lifestyle program that includes exercise, healthy eating, brain training, and managing health risks to see if it can help older adults in China avoid memory problems and dementia.

  Recruiting Zhejiang University · Hangzhou, Zhejiang · NCT05886114

• Comparing Rituximab and Ocrelizumab for Treating Relapsing Multiple Sclerosis

  This study is testing if rituximab works just as well as ocrelizumab for treating relapsing multiple sclerosis in adults.

  Recruiting Phase 3 Amsterdam UMC, location VUmc · Amsterdam · NCT05834855

• Impact of long-term ventilation support on ALS patients and their families

  This study is testing how long-term breathing support affects the quality of life for people with ALS and their families.

  Recruiting at 8 sites Haukeland University Hospital · Bodø, Nordland and 8 other locations · NCT05744310

• Transcutaneous spinal stimulation to improve blood pressure after a recent spinal cord injury

  We will try a noninvasive spinal stimulation to see if it raises and steadies blood pressure in people 7–30 days after a thoracic spinal cord injury who have low blood pressure or dizziness when sitting up.

  Recruiting Kessler Foundation · West Orange, New Jersey · NCT05731986

• Transcutaneous spinal stimulation to stabilize blood pressure after spinal cord injury

  This will test whether noninvasive transcutaneous spinal cord stimulation can raise and stabilize blood pressure in people with chronic high-level spinal cord injuries who experience orthostatic hypotension.

  Recruiting Kessler Foundation · West Orange, New Jersey · NCT05725499

• Internet-based therapy for insomnia and cognitive health

  This study is testing whether an online therapy for insomnia can help improve sleep and thinking skills in people with mild cognitive impairment.

  Recruiting Phase 2 University of Virginia · Charlottesville, Virginia · NCT05565833

• Comparing effects of carotid artery procedures on brain function and blood flow

  This study looks at how two different surgeries for blocked carotid arteries affect blood flow and thinking skills in patients over time.

  Recruiting Beijing Friendship Hospital · Beijing, Beijing Municipality · NCT05539781

• Registry for individuals with Rett syndrome

  This study is gathering information from people with Rett syndrome and their caregivers to help improve care and develop new treatments for the condition.

  Recruiting at 19 sites International Rett Syndrome Foundation · Birmingham, Alabama and 18 other locations · NCT05432349

• Collection of biological samples from patients with rare neurological diseases

  This study is trying to collect biological samples from people with rare neurological diseases to see if they can find new markers that help diagnose and treat these conditions.

  Recruiting University Hospital, Toulouse · Toulouse · NCT04698421

• Combining testosterone therapy with walking training to improve health after spinal cord injury

  This study is testing if combining testosterone therapy with walking training can help men with spinal cord injuries who have low testosterone and trouble walking improve their health and mobility.

  Recruiting at 2 sites Phase 2 North Florida Foundation for Research and Education · Gainesville, Florida and 1 other locations · NCT04460872

• Effects of Dexmedetomidine on cognitive recovery after cardiac surgery

  This study is testing if a medication called Dexmedetomidine can help people recover their thinking skills better after having heart surgery.

  Recruiting at 3 sites Phase 4 Sunnybrook Health Sciences Centre · Vancouver, British Columbia and 7 other locations · NCT04289142

• Exploring Brain Connections for Arm Movement After Stroke

  This study is testing how different parts of the brain work together to control arm movement before and after a stroke, to see if new stimulation methods can help stroke patients regain better use of their arms.

  Recruiting VA Office of Research and Development · Pittsburgh, Pennsylvania · NCT04286516

• Using a virus therapy to treat recurrent cerebellar brain tumors in children

  This study is testing a new virus treatment for children with recurring brain tumors to see if it can help them get better when combined with a low dose of radiation.

  Recruiting at 3 sites Phase 1 M.D. Anderson Cancer Center · Birmingham, Alabama and 2 other locations · NCT03911388

• A smartphone app to help manage depression symptoms

  This study is testing a smartphone app that helps people with depression track their symptoms and treatment to see if it can improve their care.

  Recruiting Centre Hospitalier Charles Perrens, Bordeaux · Bordeaux · NCT03678194

• Home-use treatment for autism using Autowave technology

  This study is testing a home device that uses special wave technology to see if it can help improve the behavior and thinking skills of people with autism.

  Recruiting at 2 sites American Federation of Medical Synergetics · Louisville, Kentucky and 1 other locations · NCT03222375

• Treatment for neurologic disorders using stem cells

  This study is testing whether using stem cells from patients' own bone marrow can help improve brain and nerve function in people with serious neurologic disorders that don't respond well to regular treatments.

  Recruiting at 3 sites MD Stem Cells · Westport, Connecticut and 2 other locations · NCT02795052

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Exploring tiny RNAs as potential markers for brain diseases linked to gammaherpesvirus.

  This study is looking at tiny pieces of genetic material linked to the Epstein-Barr virus to see if they can help doctors diagnose brain-related issues in people with weakened immune systems, and patients may be asked to share samples to help with this research.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-10839906

Related topics

Quick answers

How many Nervous System Diseases clinical trials are recruiting right now?

39, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 19 countries. The most sites are in United States (12 trials), China (8 trials), France (5 trials), Netherlands (5 trials), Germany (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 3: 2, Phase 4: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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