Slow-SPEED: Can a smartphone app help people with prodromal Parkinson's stay more active?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants with LRRK2 G2019S or GBA1 N370S mutations will use a mobile app to gradually increase daily steps and exercise time at a target heart rate over up to 36 months. The study collects digital biomarkers to form a prodromal load score, aiming to gauge changes in motor and non-motor prodromal features. Primary goals include long-term feasibility of remote, app-driven exercise and preliminary signals of effect on prodromal progression. The trial is conducted across multiple centers, leveraging a fully remote intervention with in-home activity monitoring. Eligibility requires genetic confirmation, adequate smartphone access, and ability to walk independently indoors.

Why it matters

Who can join: the full rules

Inclusion criteria

1. previously identified LRRK2 G2019S or GBA N370S variant based on genotyping
2. aged 50 years or older
3. able to understand the English language
4. being able to walk independently inside the home without the use of a walking aid
5. in possession of a suitable smartphone (screen size minimum 4.6 inch), (Android version 9 or iOS version 15 or newer)
6. Not in a high physical activity range during the 4-week eligibility and baseline period

Exclusion criteria

1. clinically diagnosed or self-reported diagnosis neurodegenerative disease
2. self-reported falls of three or more per year
3. dexterity problems or cognitive impairments hampering smartphone use
4. if they are not aware of and do not wish to be informed about an increased risk of developing diseases associated with the LRRK2 or GBA1 risk variant
5. if individual is not community-dwelling
6. in possession of one of the following devices: Huawei P8 Lite; Huawei P9 Lite; Xiaomi Mi 6; Huawei P20 Lite (Fitbit is incompatible)

Where it's running

• University of Rochester Center for Health and Technology (CHeT)
  Rochester, New York, United States Recruiting
• Radboud University Medical Center
  Nijmegen, Gelderland, Netherlands Not yet recruiting

Study contacts

• Principal investigator: Sirwan KL Darweesh, PhD — Radboudumc Department of Neurology
• Study coordinator: Thomas Oosterhof, MSc
• Email: thomas.oosterhof@radboudumc.nl
• Phone: 0031631647857

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Increasing daily physical activity to slow cognitive decline in alpha-synuclein disorders

  This study will test whether using a motivational smartphone app to increase everyday physical activity can help slow cognitive decline in people aged 50–80 with isolated REM sleep behavior disorder (an early sign of alpha‑synuclein disease).

  Recruiting University Hospital, Bonn · Bonn, North Rhine West-Falia · NCT07324330

• Increasing physical activity in patients at risk of Parkinson's disease using a smartphone app

  This study is testing a smartphone app to help people at risk of Parkinson's disease increase their physical activity and exercise intensity over two years.

  Recruiting Radboud University Medical Center · Nijmegen, Gelderland · NCT06193252

• Axial and cognitive symptoms and biomarkers in brain‑first versus body‑first Parkinson's disease

  This project will test whether clinical exams, sleep testing, heart and brain scans, and blood/CSF biomarkers can distinguish brain‑first from body‑first early Parkinson's patients and predict worsening of balance and thinking problems.

  Recruiting Azienda USL Reggio Emilia - IRCCS · Reggio Emilia · NCT07187843

• Evaluating a new treatment for cognitive function in mild Alzheimer's dementia

  This study is testing a new treatment that combines brain stimulation and cognitive training to see if it can help people with mild Alzheimer's dementia improve their thinking skills.

  Recruiting at 11 sites Advanced Technology & Communications · Incheon, Bupyeong 6(yuk)-dong, Bupyeong-gu and 10 other locations · NCT06088121

• Registering medical data and care outcomes for ALS, SMA, and other motor disorders

  This registry slowly collects routine-care information from adults with ALS, SMA, or other motor disorders to see how they’re treated and how care affects outcomes.

  Recruiting Ambulanzpartner Soziotechnologie APST GmbH · Berlin, State of Berlin · NCT07900672

• Virtual reality plus bilateral brain stimulation to improve arm and hand recovery after stroke

  We will try combining virtual reality exercises with bilateral transcranial direct current stimulation (bi‑tDCS) to improve arm and hand movement in adults at least three months after a unilateral stroke.

  Recruiting King Saud University · Riyadh · NCT07288385

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.