Effects of speech-language intervention on bilingual speakers with primary progressive aphasia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the impact of culturally and linguistically tailored speech-language interventions on bilingual individuals diagnosed with primary progressive aphasia (PPA). The study aims to understand how bilingual experience influences treatment response by administering interventions in both languages spoken by participants. It will involve 60 bilingual individuals, focusing on optimizing treatment for those who speak Spanish and either Catalan or English. The interventions include Video-Implemented Script Training for Aphasia (VISTA) and Lexical Retrieval Training (LRT).

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Meets diagnostic criteria for Primary Progressive Aphasia (PPA; Gorno-Tempini et al., 2011)
* Bilingual in Spanish and Catalan or bilingual in Spanish and English
* Different proficiency levels across languages are expected, any prior experience in both languages is acceptable
* Intervention study: Score of 15 or higher on the Mini-Mental State Examination
* Note that this project will also recruit individuals to participate in assessment only, for these individuals the following inclusion criteria applies: Score of 10 or higher on the Mini-Mental State Examination

Exclusion Criteria:

* Other central nervous system or medical diagnosis that can cause symptoms
* Other psychiatric diagnosis that can cause symptoms
* Significant, uncorrected visual or hearing impairment that would interfere with participation
* Prominent initial non-speech-language impairments (cognitive, behavioral, motoric)
* Intervention Study: Score of less than 15 on the Mini-Mental State Examination
* Note that this project will also recruit individuals to participate in assessment only, for these individuals the following inclusion criteria applies: Score of less than 10 on the Mini-Mental State Examination

Where it's running

• University of Texas at Austin
  Austin, Texas, United States Recruiting
• Hospital de la Santa Creu i Sant Pau
  Barcelona, Barcelona, Spain Recruiting
• Hospital Clínic de Barcelona
  Barcelona, Spain Not yet recruiting

Study contacts

• Principal investigator: Stephanie M Grasso, Ph.D — University of Texas at Austin
• Study coordinator: Camille Wagner Rodríguez, M.S., CCC-SLP
• Email: wagner.camille@austin.utexas.edu
• Phone: 512-471-4119

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.