Investigating Alzheimer's biomarkers in tears and blood

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the presence of Alzheimer's disease biomarkers in tear fluid and dried blood spots from patients diagnosed with Alzheimer's and other forms of dementia. Participants scheduled for a lumbar puncture at the Memory Clinic will provide tear fluid and blood samples on the same day. Additionally, a sub-study will involve participants repeating the dried blood spot collection at home one week later. The collected samples will be analyzed for Alzheimer's-related pathology alongside cerebrospinal fluid.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Inclusion criteria for patients:

* Lumbar puncture with CSF avaiable for analysis
* Diagnosis of Alzheimer's disease, Dementia with Lewy Bodies (DLB), Frontotemporal dementia (FTD), vascular dementia (VaD) or Normal pressure hydrocephalus (NPH)
* Of legal age.

Inclusion criteria for controls:

* Lumbar puncture with CSF avaiable for analysis
* No neurological disease.
* Of legal age.

Exclusion Criteria:

* No lumbar puncture
* Clinically assessed as unfit to participate in the project.

Where it's running

• Danish Dementia Research Centre
  Copenhagen, Denmark Recruiting

Study contacts

• Study coordinator: Steen G Hasselbalch, DMSc
• Email: steen.gregers.hasselbalch@regionh.dk
• Phone: +4535456922

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.