Investigating Alzheimer's biomarkers in tears and blood
Examination of Alzheimer's Disease Biomarkers in Tears and Dry Blood Spots
This study is testing if we can find signs of Alzheimer's disease in tears and blood samples from people already diagnosed with Alzheimer's and other types of dementia.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 600 (estimated) |
| Ages | 30 Years and up |
| Sex | All |
| Sponsor | Danish Dementia Research Centre Research network |
| Locations | 1 site (Copenhagen) |
| Trial ID | NCT06567431 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the presence of Alzheimer's disease biomarkers in tear fluid and dried blood spots from patients diagnosed with Alzheimer's and other forms of dementia. Participants scheduled for a lumbar puncture at the Memory Clinic will provide tear fluid and blood samples on the same day. Additionally, a sub-study will involve participants repeating the dried blood spot collection at home one week later. The collected samples will be analyzed for Alzheimer's-related pathology alongside cerebrospinal fluid.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with Alzheimer's disease, Dementia with Lewy Bodies, Frontotemporal dementia, vascular dementia, or Normal pressure hydrocephalus who are undergoing a lumbar puncture.
Not a fit: Patients who do not require a lumbar puncture or those deemed clinically unfit for participation will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to non-invasive methods for diagnosing and monitoring Alzheimer's disease.
How similar studies have performed: While the approach of using tear fluid for biomarker analysis is innovative, similar studies have shown promise in other contexts, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Inclusion criteria for patients: * Lumbar puncture with CSF avaiable for analysis * Diagnosis of Alzheimer's disease, Dementia with Lewy Bodies (DLB), Frontotemporal dementia (FTD), vascular dementia (VaD) or Normal pressure hydrocephalus (NPH) * Of legal age. Inclusion criteria for controls: * Lumbar puncture with CSF avaiable for analysis * No neurological disease. * Of legal age. Exclusion Criteria: * No lumbar puncture * Clinically assessed as unfit to participate in the project.
Where this trial is running
Copenhagen
- Danish Dementia Research Centre — Copenhagen, Denmark (Recruiting)
Study contacts
- Study coordinator: Steen G Hasselbalch, DMSc
- Email: steen.gregers.hasselbalch@regionh.dk
- Phone: +4535456922
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.