Condition

Brain Diseases clinical trials and research

• 35Clinical trials
• 1NIH research projects
• 17Countries

Newest Brain Diseases clinical trials

All recruiting trials (35)

• Selective activation of the adrenomedullin receptor to provoke migraine in adults with migraine without aura

  This study tests whether selectively activating the adrenomedullin receptor can trigger migraine attacks in adults who have migraine without aura, after blocking CGRP receptors.

  Recruiting Danish Headache Center · Glostrup Municipality · NCT07451769

• Rapamycin-coated vertebral stents for symptomatic intracranial arterial narrowing

  This trial will test whether rapamycin-coated stents placed in narrowed brain arteries can reduce the risk of stroke or death in adults whose symptoms have not improved with medicine.

  Recruiting The Affiliated Hospital of Qingdao University · Qingdao, Shandong · NCT07352852

• Increasing daily physical activity to slow cognitive decline in alpha-synuclein disorders

  This study will test whether using a motivational smartphone app to increase everyday physical activity can help slow cognitive decline in people aged 50–80 with isolated REM sleep behavior disorder (an early sign of alpha‑synuclein disease).

  Recruiting University Hospital, Bonn · Bonn, North Rhine West-Falia · NCT07324330

• Virtual reality plus bilateral brain stimulation to improve arm and hand recovery after stroke

  We will try combining virtual reality exercises with bilateral transcranial direct current stimulation (bi‑tDCS) to improve arm and hand movement in adults at least three months after a unilateral stroke.

  Recruiting King Saud University · Riyadh · NCT07288385

• Intra-arterial clot-dissolving treatment for medium-vessel ischemic stroke

  The team will test whether giving tenecteplase directly into the artery helps adults with acute ischemic stroke caused by medium-vessel blockage or severe narrowing.

  Recruiting at 6 sites The Second Hospital of Anhui Medical University · Fuyang, Anhui and 5 other locations · NCT07185022

• Vision-language AI to diagnose brain diseases from imaging and clinical data

  This project will test a new AI that reads scans, pathology, genomics, and clinical records to help diagnose a wide range of brain diseases for patients with tumors, vascular problems, or neurodegeneration.

  Recruiting Xiangya Hospital of Central South University · Changsha, Hunan · NCT07126821

• Stimulating the motor thalamus and surface cortex to improve movement and speech

  This test tries brief electrical stimulation of the motor thalamus (VOP/VIM) and nearby cortex during DBS surgery to see if it improves movement, grip strength, and speech in people having DBS for Parkinson's disease, essential tremor, stroke, or brain injury.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07056361

• Slow-SPEED: Can a smartphone app help people with prodromal Parkinson's stay more active?

  This trial tests whether a remote smartphone app can help people with a LRRK2 G2019S or GBA1 N370S mutation increase daily activity and see if exercise might slow prodromal Parkinson's signs.

  Recruiting Radboud University Medical Center · Rochester, New York and 1 other locations · NCT06993142

• Endovascular treatment for stroke beyond 24 hours

  This study is testing whether a specific stroke treatment can help people who have had a stroke more than 24 hours ago feel better and regain independence compared to just receiving standard care.

  Recruiting The Second Hospital of Anhui Medical University · Hefei, Anhui · NCT06959199

• Heart assessment to check repeat-stroke risk in people with atrial fibrillation

  This project will test whether detailed heart examinations can find which people with atrial fibrillation who just had an ischemic stroke are at high risk of having another stroke.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT06954610

• Brain biobank for research on brain diseases

  This study is setting up a brain bank to collect donated brains after death to help researchers find better ways to diagnose and treat brain diseases like Alzheimer's and dementia.

  Recruiting University of Central Florida · Orlando, Florida · NCT06876857

• Portable EEG to triage suspected stroke patients in ambulances

  This trial will test whether a portable dry‑electrode EEG headset (StrokePointer) can detect large vessel occlusion strokes in adults with suspected acute stroke so ambulance crews can take them directly to hospitals that perform thrombectomy.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, North Holland · NCT06871969

• Remote ischemic conditioning after aneurysm clipping for ruptured brain aneurysms

  This test tries brief cycles of limb cuff inflation (remote ischemic conditioning) to see if it is safe and helps recovery in adults after surgical clipping of a ruptured brain aneurysm (aneurysmal subarachnoid hemorrhage).

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT06819657

• Emergency Stroke Unit for treating acute strokes

  This study is testing a new Emergency Stroke Unit that uses a mobile MRI to see if it can help treat stroke patients faster and improve their recovery.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT06728592

• Comparing two bevifibatide dose regimens for acute ischemic stroke

  This trial will test whether two different maintenance doses of bevifibatide improve 90-day neurological recovery and reduce symptomatic brain bleeding in people with acute ischemic stroke who do not have large or medium vessel occlusion.

  Recruiting Phase 2 Zhujiang Hospital · Guangzhou, Guangdong · NCT06712004

• Evaluating therapy for patients with minor strokes and large vessel occlusion

  This study is testing different treatment options for patients with minor strokes caused by blocked large blood vessels to see which ones help them recover better.

  Recruiting Sir Run Run Shaw Hospital · Hangzhou, Zhejiang · NCT06633809

• Video call assessment for suspected stroke

  This study tests if using video calls between neurologists and emergency responders can help quickly and accurately assess patients who might be having a stroke.

  Recruiting University of Southern Denmark · Aabenraa, Region Syddanmark · NCT06570681

• Evaluating the impact of artery calcification on stroke treatment outcomes

  This study is trying to see if the amount of calcium in the arteries affects how well stroke patients do after a specific treatment for blocked blood vessels.

  Recruiting Zhujiang Hospital · Guangzhou, Guangdong · NCT06418698

• Evaluating Large Neutral Amino Acids for Treating Phenylketonuria

  This study is testing if Large Neutral Amino Acids can be a better treatment for adults with Phenylketonuria than the usual diet that limits phenylalanine.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen and 1 other locations · NCT06337864

• Increasing physical activity in patients at risk of Parkinson's disease using a smartphone app

  This study is testing a smartphone app to help people at risk of Parkinson's disease increase their physical activity and exercise intensity over two years.

  Recruiting Radboud University Medical Center · Nijmegen, Gelderland · NCT06193252

• Monitoring brain-derived tau levels in acute ischemic stroke patients

  This study is testing how brain-derived tau levels change in stroke patients over 48 hours to see if it can help understand their condition and improve treatment decisions.

  Recruiting Ludwig-Maximilians - University of Munich · Munich, Bavaria · NCT06121336

• Evaluating a new treatment for cognitive function in mild Alzheimer's dementia

  This study is testing a new treatment that combines brain stimulation and cognitive training to see if it can help people with mild Alzheimer's dementia improve their thinking skills.

  Recruiting at 11 sites Advanced Technology & Communications · Incheon, Bupyeong 6(yuk)-dong, Bupyeong-gu and 10 other locations · NCT06088121

• Using advanced microscopy to study brain tissue and improve treatment for brain diseases

  This study is testing new ways to use brain tissue samples to improve treatments for brain diseases like tumors and help doctors plan better surgeries.

  Recruiting National Taiwan University Hospital · Taipei · NCT05921786

• Multi-domain lifestyle intervention for older adults at risk of cognitive decline in China

  This study is testing a lifestyle program that includes exercise, healthy eating, brain training, and managing health risks to see if it can help older adults in China avoid memory problems and dementia.

  Recruiting Zhejiang University · Hangzhou, Zhejiang · NCT05886114

• Evaluating real-world effectiveness of endovascular thrombectomy for stroke in the Asia-Pacific region

  This study is testing how well a procedure called endovascular thrombectomy works for adults with a certain type of stroke in real-life situations across the Asia-Pacific region.

  Recruiting at 3 sites Chinese University of Hong Kong · Linyi, Shandong and 2 other locations · NCT05578300

• Analyzing brain health indicators in a large cohort

  This study looks at how medical history and body signals affect brain health and small vessel disease in a large group of people to help find ways to prevent brain problems and improve treatment for those with high blood pressure.

  Recruiting Beijing Friendship Hospital · Beijing, Beijing Municipality and 1 other locations · NCT05453877

• Combination treatment for brain metastasis from ER+/HER-2- breast cancer

  This study is testing a new combination treatment of elacestrant and abemaciclib to see if it can help people with brain metastases from estrogen receptor-positive, HER-2 negative breast cancer.

  Recruiting at 78 sites Phase 1/2 Stemline Therapeutics, Inc. · Fullerton, California and 85 other locations · NCT05386108

• Evaluating DOAC levels in Chinese patients with atrial fibrillation

  This study is testing how stopping blood-thinning medication for a short time affects Chinese patients with atrial fibrillation to see if it's safe for them during medical procedures.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT05378035

• A study on brain health and aging in Bordeaux.

  This study is trying to understand how different factors, like diet and health, affect brain aging and the risk of dementia in people aged 55 and older living in Bordeaux.

  Recruiting University Hospital, Bordeaux · Bordeaux, Bordeaux · NCT05322343

• Enhancing memory through amygdala stimulation

  This study is testing if stimulating a part of the brain called the amygdala can help improve memory in people with epilepsy who are being monitored for seizures.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT05065450

• Short mild low-oxygen sessions to support brain blood-vessel health in older adults

  We will test whether brief, controlled sessions of mild low-oxygen exposure, alone or combined with rehabilitative exercise, can improve brain blood-vessel function in inactive people aged 60 to 80.

  Recruiting University Hospital, Grenoble · La Tronche, Auvergne-Rhône-Alpes · NCT05048680

• Using virtual reality glasses to improve balance in stroke patients

  This study tests if using virtual reality glasses can help stroke patients improve their balance and body orientation by changing how they see verticality.

  Recruiting University Hospital, Grenoble · Grenoble · NCT04911738

• Using a virus therapy to treat recurrent cerebellar brain tumors in children

  This study is testing a new virus treatment for children with recurring brain tumors to see if it can help them get better when combined with a low dose of radiation.

  Recruiting at 3 sites Phase 1 M.D. Anderson Cancer Center · Birmingham, Alabama and 2 other locations · NCT03911388

• A smartphone app to help manage depression symptoms

  This study is testing a smartphone app that helps people with depression track their symptoms and treatment to see if it can improve their care.

  Recruiting Centre Hospitalier Charles Perrens, Bordeaux · Bordeaux · NCT03678194

• Longitudinal study on brain health and risk factors for neurological diseases

  This study is trying to understand how different health factors affect brain health over time in people who are at risk for conditions like stroke and dementia.

  Recruiting at 2 sites Chinese University of Hong Kong · Hong Kong and 1 other locations · NCT03592563

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Developing targeted gene therapies for rare genetic brain diseases

  This study is working on new ways to deliver gene therapy specifically for rare brain disorders caused by harmful genes, like Spinocerebellar Ataxia Type 7, to help improve treatment options for patients.

  NIH research University of California-Irvine · Irvine, United States · NIH-10694918

Related topics

Quick answers

How many Brain Diseases clinical trials are recruiting right now?

35, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in China (11 trials), United States (6 trials), France (5 trials), Hong Kong (4 trials), Denmark (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 1, Phase 2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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