Understanding how tau protein affects brain function in aging and neurodegenerative diseases
Tau-mediated synaptic dysfunction in age-related neurodegenerative diseases
This study is looking at how a protein called tau affects brain connections as we age, especially in people with Alzheimer's, to help find ways to prevent memory loss and other problems related to aging.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11032725 on NIH RePORTER |
What this research studies
This research investigates the role of tau protein in causing synaptic dysfunction in the aging brain, particularly in conditions like Alzheimer's disease. It aims to uncover the cellular mechanisms by which abnormal tau accumulation leads to cognitive decline and synapse loss. The study employs advanced techniques in biochemistry, microscopy, and electrophysiology to explore these mechanisms. By understanding these processes, the research seeks to pave the way for developing preventative therapies for age-related neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing cognitive decline or diagnosed with Alzheimer's disease or related tauopathies.
Not a fit: Patients with cognitive impairments not related to tau pathology or those with early-stage neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that help preserve cognitive function in patients with age-related neurodegenerative diseases.
How similar studies have performed: Previous research has shown promising results in understanding tau's role in neurodegeneration, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Weber, Audrey — University of Alabama at Birmingham
- Study coordinator: Weber, Audrey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.