Fisetin approach to reduce vulnerability to community infections in aging veterans
Official title: Fisetin as a treatment for community-acquired pathogen susceptibility during aging, obesity and neurodegenerative diseases
Funded at Minneapolis VA Medical Center · NIH-11415406 · Data updated 2026-11-12
A patient-friendly look at a study testing whether the natural compound fisetin can help aging Veterans stay healthier when they face common infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Minneapolis VA Medical Center NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | April 1, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2026 |
| NIH project number | 5I01RX003901-05 |
| Project ID | NIH-11415406 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults over 21 who are aging, possibly with obesity or neurodegenerative conditions and Veteran status.
✕Less likely to help
Individuals without aging-related health concerns or who are not in the Veteran population may see limited relevance.
What this research studies
This project focuses on older adults, especially Veterans, who often have age-related health issues like obesity and neurodegeneration. It explores whether fisetin can target aging mechanisms to reduce vulnerability to community-acquired infections. The research will consider how aging cells influence immune responses and how senolytic strategies might improve overall health and resistance to infections. Participants would come from the Veteran community and contribute to understanding how aging biology affects infection outcomes.
Why it matters
Potential benefit: If successful, the approach could lead to strategies that help aging Veterans stay healthier when exposed to common infections.
How similar studies have gone: Animal studies and early aging research suggest senolytic approaches can improve tissue function and healthspan, but human data are still emerging.
Where this research is happening
-
Minneapolis VA Medical Center
Minneapolis, United States Active
Researchers
- Principal investigator: Kotz, Catherine M — Minneapolis VA Medical Center
- Study coordinator: Kotz, Catherine M
Related research
Other NIH-funded projects on the same topics.
-
Tau filament structure in Alzheimer’s and related dementias
Aims to map the detailed 3D shapes of tau protein filaments found in human brain diseases to help develop better diagnostics and treatments for Alzheimer’s-related dementias.
-
How obesity affects children's breathing as they grow up
This study follows children with obesity and without obesity as they age to see how body fat, lung function, exercise ability, and breathlessness change over six years.
-
Advancing Aging, Obesity, and Body Composition Care
Aimed at building training and leadership in aging, obesity, and body composition research to help older adults stay healthier.
-
Decoding the sperm RNA code and its link to obesity and fertility
Researchers are studying how the tiny RNAs in sperm change with aging and obesity, and what that could mean for a child’s health.
-
Boosting NAD to help blood sugar control in aging and obesity
This project is trying to see if raising levels of a molecule called NAD can help older adults and people with obesity keep their blood sugar more stable.
-
Structure of amyloid filaments in brain diseases and aging
Researchers study the tiny structures of protein filaments that build up in brain diseases like Alzheimer's and other dementias to understand how they form and vary.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.