Condition

Neurocognitive Disorders clinical trials and research

• 23Clinical trials
• 14NIH research projects
• 9Countries

Newest Neurocognitive Disorders clinical trials

All recruiting trials (23)

• Non-invasive brain stimulation plus computer-based memory training for mild cognitive impairment

  This trial will test whether a short course of non-invasive brain stimulation combined with one of two computer-based brain-training programs helps people aged 60–85 with mild cognitive impairment improve memory, thinking, mood, and daily function.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07526740

• Developing and testing the Liver Cirrhosis Cognitive Decline Scale (LiCCoS)

  This project will test a short questionnaire called LiCCoS to see if it can spot thinking and everyday mental problems in adults with liver cirrhosis.

  Recruiting University of Malaya · Ambāla, Haryana · NCT07418008

• Carotid artery wall viscosity and memory problems in older adults

  This project will test whether the viscous behavior of the carotid artery wall is linked to memory problems in people over 70 with memory complaints, Alzheimer's disease, or vascular dementia.

  Recruiting University Hospital, Rouen · Rouen · NCT07205003

• NeuroFirst brain protection for adults having heart bypass surgery

  This trial tests whether a bundled anesthesia approach called NeuroFirst can help people aged 60 and older having planned heart surgery with cardiopulmonary bypass avoid silent brain infarcts and thinking or memory problems after surgery.

  Recruiting at 5 sites Chinese Academy of Medical Sciences, Fuwai Hospital · Beijing, Beijing Municipality and 4 other locations · NCT07048002

• Nutrition-based interventions to prevent cognitive decline

  This study is testing if a 6-month nutrition program can help adults at higher risk for dementia keep their thinking skills sharp.

  Recruiting at 2 sites Instituto de Saude Publica da Universidade do Porto · Porto, Portugal and 1 other locations · NCT06853405

• Oral midazolam to help deliver care for older adults with neurocognitive disorders who refuse care

  This study will try a short-acting oral midazolam to help nurses and caregivers give essential care to older adults with moderate to severe neurocognitive disorders who resist or refuse care.

  Recruiting Phase 2 University Hospital, Grenoble · Grenoble, Isere · NCT06638710

• Intelligent digital health companion for neurocognitive disorders and caregivers

  This study is testing a digital health tool called 'Talk-to-Jo' to see if it can help older adults with neurocognitive disorders and their caregivers in Quebec feel better and manage their challenges.

  Recruiting Centre integre universitaire de sante et de services sociaux du Centre-Sud-de-l'Île-de-Montréal · Montreal, Quebec · NCT06606353

• Personalized interventions for older adults with mild behavioral impairment

  This study is testing personalized non-drug treatments for older adults with mild behavioral issues to see if they can improve symptoms and help delay dementia.

  Recruiting Fujian Provincial Hospital · Fuzhou, Fujian · NCT06416514

• Evaluating a new treatment for cognitive function in mild Alzheimer's dementia

  This study is testing a new treatment that combines brain stimulation and cognitive training to see if it can help people with mild Alzheimer's dementia improve their thinking skills.

  Recruiting at 11 sites Advanced Technology & Communications · Incheon, Bupyeong 6(yuk)-dong, Bupyeong-gu and 10 other locations · NCT06088121

• Comparing intravenous and inhalational anesthesia in older adults

  This study is testing whether using intravenous anesthesia instead of inhalational anesthesia can help older adults have better recovery outcomes after non-cardiac surgery.

  Recruiting Phase 4 Oregon Health and Science University · Portland, Oregon · NCT06036095

• Detecting Alzheimer's and mood disorders through voice analysis

  This study is testing whether analyzing voice patterns can help detect Alzheimer's and mood disorders without needing invasive tests like spinal taps or scans.

  Recruiting Centre Hospitalier Universitaire de Nice · Nice · NCT05943834

• Comparing two approaches to prevent delirium in hospitalized older adults

  This study tests whether involving family members in care can help prevent delirium in older adults during hospital stays better than the standard Hospital Elder Life Program alone.

  Recruiting at 7 sites University of Michigan · Orange, California and 6 other locations · NCT05929703

• Multi-domain lifestyle intervention for older adults at risk of cognitive decline in China

  This study is testing a lifestyle program that includes exercise, healthy eating, brain training, and managing health risks to see if it can help older adults in China avoid memory problems and dementia.

  Recruiting Zhejiang University · Hangzhou, Zhejiang · NCT05886114

• Neurodevelopmental outcomes in children of mothers with Type 1 diabetes

  This study is testing how having Type 1 diabetes during pregnancy affects children's thinking skills and behaviors related to autism and ADHD, by gathering information from mothers in several countries.

  Recruiting at 9 sites University of Manitoba · Calgary, Alberta and 9 other locations · NCT05754567

• Effects of speech-language intervention on bilingual speakers with primary progressive aphasia

  This study tests if special speech therapy designed for bilingual people can help those with primary progressive aphasia communicate better in both of their languages.

  Recruiting at 2 sites University of Texas at Austin · Austin, Texas and 2 other locations · NCT05741853

• Tool for assessing memory in older adults

  This study is testing a new memory tool for older adults aged 70 and up to see if it can help spot early signs of memory problems, especially in those with or without neurocognitive disorders.

  Recruiting Centre Hospitalier de Lens · Lens · NCT05668598

• Cohort study on Alzheimer's risk in first-degree relatives

  This study looks at how likely first-degree relatives of Alzheimer's patients are to develop the disease themselves and what factors might affect that risk.

  Recruiting Ruijin Hospital · Shanghai, Shanghai Municipality · NCT05597410

• Using brain stimulation to treat apathy in Alzheimer's disease

  This study is testing whether a brain stimulation treatment can help reduce feelings of apathy in people with Alzheimer's disease, including those who are taking a medication for it.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT05561205

• Using a cognitive app to assess brain tumor patients' quality of life

  This study tests whether a brain health app can help doctors understand the quality of life and cognitive function of adults treated for brain tumors at the Miami Cancer Institute.

  Recruiting Baptist Health South Florida · Miami, Florida · NCT05504681

• A study on brain health and aging in Bordeaux.

  This study is trying to understand how different factors, like diet and health, affect brain aging and the risk of dementia in people aged 55 and older living in Bordeaux.

  Recruiting University Hospital, Bordeaux · Bordeaux, Bordeaux · NCT05322343

• Using a passive home sensor to find digital signs of brain energy changes from nicotinamide riboside

  This project will try a contact-free home sensor to see if it can detect activity, sleep, and breathing changes related to nicotinamide riboside in people with mild cognitive impairment or mild Alzheimer's.

  Recruiting Mclean Hospital · Belmont, Massachusetts · NCT05245903

• Assessment of cognitive disorders using ultrasound at a day hospital

  This study is testing if ultrasound can help track changes in thinking and memory for patients with cognitive disorders over five years.

  Recruiting University Hospital, Tours · Tours · NCT05129150

• Effects of Dexmedetomidine on cognitive recovery after cardiac surgery

  This study is testing if a medication called Dexmedetomidine can help people recover their thinking skills better after having heart surgery.

  Recruiting at 3 sites Phase 4 Sunnybrook Health Sciences Centre · Vancouver, British Columbia and 7 other locations · NCT04289142

NIH-funded research (14)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Biomarkers and Causes of Post-Surgery Brain Changes in Older Adults

  A study in adults 65 and older will look at blood biomarkers and gut microbes to understand why some people have cognitive changes after surgery.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11449845

• Personalized anesthesia monitoring to prevent post-op cognitive problems in older adults

  A new approach combines an FDA-cleared brain-monitoring device with a quick in-hospital cognitive check to tailor anesthesia and reduce delirium and memory problems in people 65 and older.

  NIH research Pascall Systems, Incorporated · Boston, UNITED STATES · NIH-11400076

• Circadian rhythms and sleep disorders in perioperative cognitive changes

  A study from Massachusetts General Hospital looks at how circadian rhythm problems and sleep disorders may influence brain problems patients experience around surgery.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11398103

• Using a quick thinking-and-memory check plus a wireless brain monitor to reduce thinking problems after surgery in older adults

  This project pairs a short thinking and memory check with a wireless brain monitor during surgery to help people 65 and older avoid memory and thinking problems afterward.

  NIH research Pascall Systems, Incorporated · Boston, UNITED STATES · NIH-11375766

• PNU-120596 for HIV-related thinking and memory problems

  This project tests whether PNU-120596, a drug that boosts a brain receptor, can protect the brain and reduce thinking and memory problems in people living with HIV.

  NIH research Rosalind Franklin Univ of Medicine & Sci · North Chicago, United States · NIH-11312683

• Ketone-based approaches to improve sleep, anesthesia safety, and memory in older adults

  Looks at whether giving the brain ketone fuel can improve sleep, lower anesthesia-related brain problems, and support memory in older adults and people with Alzheimer's.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11300188

• Vascular factors and HIV-related brain changes in HIV-positive people

  This grant supports studying how blood vessel problems and HIV together affect brain aging and dementia risk in people living with HIV.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11175393

• Using a new drug to improve brain health in people with HIV-related cognitive issues

  This study is looking at a new drug called PNU-120596 to see if it can help protect brain cells and improve thinking skills in people with HIV-related brain issues.

  NIH research Rosalind Franklin Univ of Medicine & Sci · North Chicago, United States · NIH-11098771

• Improving sleep and brain health in older adults with metabolic treatments

  This study is looking at how giving special energy sources called ketones can help older adults sleep better and stay safe during anesthesia, while also supporting brain health for those with conditions like Alzheimer's.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11035190

• How antiretroviral therapy affects brain cells in people with HIV.

  This study is looking at how a process in brain support cells called autophagy affects thinking and memory problems in people with HIV, and how HIV medications might change this process to help find better treatments for those issues.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-10899683

• How HIV affects brain health and blood vessel function in aging patients

  This study is looking at how living with HIV affects heart and brain health as people get older, especially in those with other health issues like high blood pressure or diabetes, to find ways to help improve thinking and memory skills.

  NIH research Columbia University Health Sciences · New York, United States · NIH-10888208

• Using computer speech analysis to diagnose Alzheimer's and other neurocognitive disorders

  This study is looking at how computer analysis of speech can help doctors spot early signs of memory problems like Alzheimer's, making it easier for them to help people who might be experiencing these issues.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10840410

• Combining cognitive assessments with brain monitoring to prevent cognitive disorders after surgery in older patients

  This study is looking to make anesthesia safer for older patients by using a special brain monitor during surgery to help doctors avoid giving too much sedation, which can sometimes cause memory problems afterward.

  NIH research Pascall Systems, Incorporated · Boston, UNITED STATES · NIH-10760816

• Understanding how surgery affects brain function in at-risk patients

  This study is looking at how surgery might affect thinking and memory in patients who are more likely to have problems afterward, like those with sleep apnea, and it aims to find ways to help these patients feel better after their operations.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10692867

Related topics

Quick answers

How many Neurocognitive Disorders clinical trials are recruiting right now?

23, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in France (6 trials), United States (6 trials), China (4 trials), Canada (4 trials), Spain (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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