Condition

Synucleinopathies clinical trials and research

• 8Clinical trials
• 9Countries

Newest Synucleinopathies clinical trials

All recruiting trials (8)

• Early PD signals in people with REM sleep behavior disorder

  This study tests whether people with REM sleep behavior disorder show early signs of Parkinson’s disease before classic symptoms appear.

  Recruiting Danish Research Centre for Magnetic Resonance · Hvidovre · NCT07790744

• Donanemab in Early Cognitive Decline with Lewy Body Features (TRAILBLAZER-ALZ 7)

  This trial tests donanemab versus placebo to see if it can slow thinking and daily-function decline in people with early cognitive decline and Lewy body disease features.

  Recruiting at 47 sites Phase 2 Eli Lilly and Company · Chandler, Arizona and 71 other locations · NCT07589595

• Swedish BioFINDER Sleep program for early Parkinson's disease and REM sleep behavior disorder

  This project will test whether sleep studies, brain and heart imaging, and fluid biomarkers can identify synuclein pathology and help predict progression in people with early Parkinson's disease or idiopathic REM sleep behavior disorder.

  Recruiting Skane University Hospital · Malmö · NCT07533799

• Increasing daily physical activity to slow cognitive decline in alpha-synuclein disorders

  This study will test whether using a motivational smartphone app to increase everyday physical activity can help slow cognitive decline in people aged 50–80 with isolated REM sleep behavior disorder (an early sign of alpha‑synuclein disease).

  Recruiting University Hospital, Bonn · Bonn, North Rhine West-Falia · NCT07324330

• Axial and cognitive symptoms and biomarkers in brain‑first versus body‑first Parkinson's disease

  This project will test whether clinical exams, sleep testing, heart and brain scans, and blood/CSF biomarkers can distinguish brain‑first from body‑first early Parkinson's patients and predict worsening of balance and thinking problems.

  Recruiting Azienda USL Reggio Emilia - IRCCS · Reggio Emilia · NCT07187843

• Slow-SPEED: Can a smartphone app help people with prodromal Parkinson's stay more active?

  This trial tests whether a remote smartphone app can help people with a LRRK2 G2019S or GBA1 N370S mutation increase daily activity and see if exercise might slow prodromal Parkinson's signs.

  Recruiting Radboud University Medical Center · Rochester, New York and 1 other locations · NCT06993142

• Collecting data on neurodegenerative diseases progression markers

  This study is trying to find new signs that can help doctors understand how neurodegenerative diseases like Parkinson's progress, so they can improve early treatment options for patients.

  Recruiting IRCCS San Raffaele Roma · Cassino, Frosinone · NCT06596746

• Increasing physical activity in patients at risk of Parkinson's disease using a smartphone app

  This study is testing a smartphone app to help people at risk of Parkinson's disease increase their physical activity and exercise intensity over two years.

  Recruiting Radboud University Medical Center · Nijmegen, Gelderland · NCT06193252

Related topics

Quick answers

How many Synucleinopathies clinical trials are recruiting right now?

8, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in Italy (2 trials), United States (2 trials), Netherlands (2 trials), Germany (1 trial), Japan (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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